Abstract:
OBJECTIVES:The relationship between rheumatoid arthritis (RA) and the risk of leukemia was still controversial. This study aimed to assess the risk of leukemia in patients with rheumatoid arthritis by systematic review and meta-analysis. METHODS:Relevant studies were identified by searching PubMed, Embase, Cochrane Library, and SinoMed up to December 2019. Random effects model analysis was used to pool standardized incidence ratios (SIRs) and 95% confidence interval. RESULTS:A total of 15 relevant studies that met the criteria were included. Compared with the general population, patients with RA showed an increased risk of leukemia (SIR = 1.51, 95% CI: 1.34-1.70). The statistical heterogeneity was moderate with an I2 of 55.5%. In subgroup analysis, the source of heterogeneity may be due to differences in sample size. Publication bias was not found in the Begg funnel plot and the Egger test. CONCLUSION:Our findings suggested that the risk of leukemia in RA was increased compared with the general population. Key points • This is the first systematic review and meta-analysis to assess the risk of leukemia in RA. • Our study suggested that the risk of leukemia in RA was increased compared with the general population. • This study indicated that the risk of leukemia in RA was higher in non-Asian populations.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Luo X,He Y,Xu W,Liu M,Zhao Z,Peng L,He C,Chen Jdoi
10.1007/s10067-020-05396-7subject
Has Abstractpub_date
2020-09-17 00:00:00eissn
0770-3198issn
1434-9949pii
10.1007/s10067-020-05396-7pub_type
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章,评审
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