Abstract:
:Adult-onset Still's disease (AOSD) has often been regarded as the adult spectrum of systemic juvenile idiopathic arthritis (sJIA). The present study aims to compare the clinical and laboratory features, the disease course and the response to treatment in patients having AOSD with those having sJIA. Retrospective review of all available data that were filled out by adult and paediatric rheumatologists from six centers using a standard data extraction form was performed. A total of 95 patients with AOSD and 25 patients with sJIA were recruited for the study. The frequency of fever, rash, myalgia, weight loss and sore throat was higher in patients with AOSD. The pattern of joint involvement differed slightly. Laboratory findings were similar in both groups, except that liver dysfunction and neutrophilia were more common among adults. A multiphasic pattern dominated the childhood cases, whereas the most frequent course was a chronic one in adults. Corticosteroids and methotrexate were the most commonly employed therapy; however, chloroquine was another popular therapy in the adult group. We showed a difference in the rate of clinical and laboratory features between patients with AOSD and those with sJIA. AOSD and sJIA may still be the same disease, and children may simply be reacting differently as the result of the first encounter of the putative antigens with the immune system.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Pay S,Türkçapar N,Kalyoncu M,Simşek I,Beyan E,Ertenli I,Oztürk MA,Düzgün N,Erdem H,Ozbalkan Z,Kiraz S,Kinikli G,Besbas N,Dinç A,Ateş A,Olmez U,Calgüneri M,Aydintuğ OT,Bakkaloğlu A,Turan M,Turgay M,Karaaslan Y,doi
10.1007/s10067-005-0138-5subject
Has Abstractpub_date
2006-09-01 00:00:00pages
639-44issue
5eissn
0770-3198issn
1434-9949journal_volume
25pub_type
杂志文章,多中心研究abstract::Familial Mediterranean fever (FMF) is an autoinflammatory disorder. It is caused by mutations in the MEFV gene encoding the pyrin protein, which regulates the innate inflammatory response. The aim of the current study was to investigate the relationship between serum Interleukin-4 (IL-4) and its gene polymorphism, nam...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4214-z
更新日期:2018-12-01 00:00:00
abstract::Idiopathic paroxysmal rhabdomyolysis indicating a classical triad of symptoms consisting of muscle pain, weakness, and discolored urine is known as "Meyer-Betz syndrome". It may result in acute renal failure due to precipitation of the myoglobin casts in the tubuli or to the direct toxic effects of myoglobin to the tu...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-005-0091-3
更新日期:2006-11-01 00:00:00
abstract::Vascular endothelial growth factor (VEGF) is known to be involved in the pathogenesis of rheumatoid arthritis (RA). In order to elucidate the association between VEGF levels and RA disease activity, VEGF concentrations were measured in RA patients at different phases and severity levels. Thirty-eight healthy subjects ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-009-1343-4
更新日期:2010-05-01 00:00:00
abstract::To validate the Quality of Life-Rheumatoid Arthritis Scale II (QOL-RA II) in an Argentinean cohort of patients with rheumatoid arthritis (RA). Patients ≥ 18 years old, with a diagnosis of RA according to ACR-EULAR 2010 criteria, were included in a cross-sectional study. Sociodemographic data, comorbidities, RA charact...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05139-8
更新日期:2020-11-01 00:00:00
abstract::Our aim is to investigate the effects of three therapeutic approaches in the chronic low back pain on pain, spinal mobility, disability, psychological state, and aerobic capacity. Sixty patients with chronic low back pain were randomized to three groups: group 1, aerobic exercise + home exercise; group 2, physical the...
journal_title:Clinical rheumatology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10067-007-0815-7
更新日期:2008-07-01 00:00:00
abstract::The purpose of this report is to describe the overall safety profile of both short- and longer-term duloxetine treatment of fibromyalgia. Data from four double-blind, randomized, placebo-controlled studies (two with 6-month open-label extension phases) and a 1-year, open-label safety study were included. Safety measur...
journal_title:Clinical rheumatology
pub_type: 杂志文章,meta分析
doi:10.1007/s10067-009-1203-2
更新日期:2009-09-01 00:00:00
abstract::Atherosclerosis plays a key role in cardiovascular disease in patients with rheumatoid arthritis (RA). Although therapy with TNF-alpha antagonists has resulted in dramatic improvement in the prognosis of RA, its effects on circulatory lipids are unclear. We conducted a systematic review of the literature to summarize ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-010-1405-7
更新日期:2010-09-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a multi-system chronic inflammatory disease with a broad spectrum of clinical and serological manifestations. Although clinical evidence of proximal skeletal muscle involvement is not rare in patients with SLE, there is no knowledge about the effects of SLE on the macroscopic stru...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-013-2249-8
更新日期:2013-08-01 00:00:00
abstract::Susceptibility to systemic lupus erythematosus (SLE) is associated with genetic, hormonal, immunological, and environmental factors. Many genes have been related with the appearance of SLE, including several loci that code different complement components and their receptors. Some genetic deficiencies of complement mol...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-008-0838-8
更新日期:2008-04-01 00:00:00
abstract:OBJECTIVE:We aimed to evaluate the effect on renal functions and blood pressure of the addition of low dose aspirin (LDA) to cyclooxygenase-2 (COX-2) inhibitors or nonselective NSAIDs. METHODS:Two groups each containing 14 patients with one group using celecoxib and the other indomethacin regularly for at least 1 week...
journal_title:Clinical rheumatology
pub_type: 临床试验,信件
doi:10.1007/s10067-005-1167-9
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVE:Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are rare small to medium-size vessel systemic diseases. As their clinical picture, organ involvement, and factors influencing outcome may differ between countries and geographical areas, we decided to describe a large cohort of Polish AA...
journal_title:Clinical rheumatology
pub_type: 杂志文章,多中心研究
doi:10.1007/s10067-019-04538-w
更新日期:2019-09-01 00:00:00
abstract::It has recently been claimed that some of the symptoms in patients with Behçet's disease (BD) can be activated after the patient has stopped smoking. In this study we investigated the effect of smoking on the symptoms of Behçet's disease. Fifty asymptomatic current smokers (CS) who promised to stop smoking (group 1) a...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670070020
更新日期:2000-01-01 00:00:00
abstract::Expectancies play a major role for the treatment outcome of a broad variety of immune-mediated conditions and may strengthen or mimic the effects of regular long-term therapies. This study adds to a recently published study of Kox et al. (PNAS 111:7379-7384, 2014) on the ability to voluntarily influence the physiologi...
journal_title:Clinical rheumatology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10067-015-3009-8
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVE:The association between hyperuricemia and insulin resistance (IR) has been demonstrated by many studies, but the traditional IR indexes are too impractical to be used in clinical practice for the recognition of the IR state in individuals with hyperuricemia. Therefore, we aimed to further investigate the asso...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-019-04671-6
更新日期:2019-11-01 00:00:00
abstract::A case of left brachial plexus compression by an iatrogenic arteriovenous fistula was treated by detachable balloon technique with immediate relief of pain. Good results on paresia were obtained in a few weeks. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02330599
更新日期:1987-12-01 00:00:00
abstract::To investigate the histological changes of synovium in cases of effect attenuation occurring after the use of infliximab in the treatment of rheumatoid arthritis (RA), we histologically assessed synovial tissue from ten methotrexate-treated RA patients and 12 infliximab-treated RA patients after arthroscopic synovecto...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-008-0850-z
更新日期:2008-06-01 00:00:00
abstract::To compare the diagnostic powers of rheumatoid factor (RF) and anti-cyclic citrullinated peptide (CCP) in a population selected for its high statistical relevance, over a 6-month period, an informed consent to test for anti-CCP was obtained from 1,025 consecutive patients for whom RF was ordered at a University labora...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-007-0601-6
更新日期:2007-11-01 00:00:00
abstract::Sudden death following steroid pulse therapy has been recently reported. Continuous electrocardiographic recording was performed 24 hours before, during, and 24 hours after each one to three high dose intravenous methyl prednisolone pulses administered of five patients with severe ankylosing spondylitis unresponsive t...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02715692
更新日期:1984-03-01 00:00:00
abstract::In 1960 Rabinowitz and Dameshek emphasized the close relationship between idiopathic thrombocytopenic purpura (ITP) and systemic lupus erythematosus (SLE) and suggested that ITP is often a prodrome of SLE. On the basis of tis observation, the present study was designed to investigate the prevalence of SLE in patients ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02041395
更新日期:1983-09-01 00:00:00
abstract::The prognostic significance of class III major histocompatibility complex complement components, factor B (Bf), C4A and C4B, were studied in a 3-year prospective study of 73 patients with early RA. Patients with C4B null allele had higher disease activity with more radiological progression than patients with C4A null ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02238550
更新日期:1996-11-01 00:00:00
abstract::Distinction between infection and febrile disease flare in patients with systemic lupus erythematosus (SLE) is fundamental but often difficult to make, because clinical presentation can be similar. A systematic review of all articles indexed in PubMed through October 2013 was performed, in order to examine the potenti...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-014-2738-4
更新日期:2014-09-01 00:00:00
abstract::The aim of this study was to evaluate whether dexibuprofen meets the basic requirements of Dutch General Practitioners (GPs) for acceptance as an analgesic in mild to moderate pain. The available GP treatment standards for mild to moderate pain were analysed. If no treatment standard was available, results from two se...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF03342660
更新日期:2001-11-01 00:00:00
abstract::Osteonecrosis (ON) is a clinical entity characterized by death of bone marrow and trabecular bone as a result of disruption of blood supply to the bone. The antiphospholipid (APL) syndrome is characterized by arterial and/or venous thrombosis and pregnancy morbidity in association with APL antibodies. The involvement ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-007-0716-9
更新日期:2008-02-01 00:00:00
abstract::Articular involvement is described in a 58-year-old female patient with scleroderma. Radiological findings included intra-articular calcification, destructive osteoarthritis and selective involvement of the first metacarpal base. The discussion attempts to explain the way in which intra-articular calcification and ost...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02032338
更新日期:1984-09-01 00:00:00
abstract::This study quantified the association between recreational physical activity and daily function in women with fibromyalgia, and determined if this association is mediated by symptoms of pain, depression, or body mass. Twenty-three women diagnosed with fibromyalgia participated in an observational survey study. Recreat...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-013-2386-0
更新日期:2015-01-01 00:00:00
abstract::The aims of the study were to assess the health-related quality of life (QOL) in patients with Takayasu's arteritis (TA) by two different generic QOL instruments and to compare the results with those patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS), and healthy controls (HC). A cross-sectional stud...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-007-0813-9
更新日期:2008-07-01 00:00:00
abstract::The aim of this study was to describe a single-center experience in the treatment and follow-up of cystoid macular edema patients. Clinical records of all patients with cystoid macular edema followed up in the Rheumatologic and Ophthalmological Unit of our center between 1993 and 2013 were retrospectively evaluated. T...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-014-2694-z
更新日期:2015-04-01 00:00:00
abstract::The original version of this article contained error. Table 1 was shown in the wrong version, thus corrected table is shown in this article. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,已发布勘误
doi:10.1007/s10067-019-04480-x
更新日期:2019-06-01 00:00:00
abstract::With the aim of evaluating the role of 1,25 dihydroxyvitamin D in the pathogenesis of osteoporosis, this hormone was studied in 90 subjects. They were divided into three groups: the first group consisted of 30 normal female subjects (aged 30 to 45); the second group comprised 30 elderly female subjects (aged 67 to 90)...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02031970
更新日期:1990-06-01 00:00:00
abstract::B cells in patients with rheumatoid arthritis (RA) are hyperactivated. Although B cell receptor signal transduction may be affected by various response regulators, CD22 plays an important role as a response regulator of B cells. Therefore, we investigated and examined CD22 expression on peripheral blood B cells of pat...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-007-0665-3
更新日期:2007-10-01 00:00:00