Abstract：
:Vascular endothelial growth factor (VEGF) is known to be involved in the pathogenesis of rheumatoid arthritis (RA). In order to elucidate the association between VEGF levels and RA disease activity, VEGF concentrations were measured in RA patients at different phases and severity levels. Thirty-eight healthy subjects and 40 patients with RA were prospectively included in the study. Subjects were further categorized into four subgroups (high, moderate, low, or remission) using the disease activity score-28 (DAS28) scoring system. VEGF levels were significantly higher in patients than controls (p < 0.001). VEGF levels differed significantly in controls, early and late-phase RA patients (p = 0.002). A significant difference was found between controls and patients with high RA disease activity scores (p < 0.0001). VEGF levels were not correlated with age (r = -0.016; p = 0.921) or sex (r = 0.209; p = 0.921). VEGF values were correlated with erythrocyte sedimentation rate (r = 0.445; p = 0.004), but was not correlated with serum rheumatoid factor levels (r = -0.130; p = 0.424) in the patient group. In conclusion, higher VEGF levels are associated with late phase and high disease activity in RA, independent of age and sex.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Ozgonenel L,Cetin E,Tutun S,Tonbaklar P,Aral H,Guvenen Gdoi
10.1007/s10067-009-1343-4subject
Has Abstractpub_date
2010-05-01 00:00:00pages
473-7issue
5eissn
0770-3198issn
1434-9949journal_volume
29pub_type
杂志文章abstract：:Hundreds of randomized controlled trials (RCTs) on tripterygium glycosides tablet (TGT) in the treatment of ankylosing spondylitis (AS) have been published, but the therapeutic effects have never been systematically reviewed yet. The aim of this meta-analysis was to evaluate the efficacy of TGT on AS based on RCTs. Pu...
journal_title：Clinical rheumatology
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s10067-015-3043-6
更新日期：2015-11-01 00:00:00
abstract：:One hundred and eighteen elbows in 59 patients who started treatment using disease-modifying antirheumatic drugs (DMARDs) in the first year of the disease were followed-up for more than 10 years without biologic agents. Using annual radiographs of the elbow joint, Larsen grade (LG) was determined, and bone absorption ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-007-0814-8
更新日期：2008-07-01 00:00:00
abstract：:The aim of this study was to ascertain whether fibromyalgia patients with positive ANA develop other features of connective tissue disease over 2-4 years' follow-up. Patients attending our clinic with a diagnosis of fibromyalgia were identified. All ANA-positive patients (n = 12) were recruited and matched for age and...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s100670200118
更新日期：2002-11-01 00:00:00
abstract：:Forty-three of fifty-eight (74.1%) female patients with fibromyalgia completed an eight-week treatment period testing the combination of carisoprodol, paracetamol (acetaminophen) and caffeine versus placebo. Twenty-three patients received placebo and twenty active medication. In the placebo group 56.5% of the patients...
journal_title：Clinical rheumatology
pub_type： 临床试验,杂志文章
doi：10.1007/BF02030081
更新日期：1989-06-01 00:00:00
abstract：:After longterm treatment (mean duration 7.2 years) with antihyperuricemic drugs, ten tophaceous gouty patients requested withdrawal of the medication because they had not felt any arthritic pains for years, the tophi had disappeared, and they disliked the idea of taking the medicine daily for the rest of their lives. ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02201004
更新日期：1987-03-01 00:00:00
abstract：:The authors report a case of a 20-year-old woman with Takayasu's arteritis (TA) presenting with recurrent erythema nodosum-like lesions, elevated acute-phase proteins and aortographic findings of multiple aneurysmal dilatations of the aorta without the coexistence of steno-occlusive lesions. This finding indicates tha...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s100670050162
更新日期：2000-01-01 00:00:00
abstract：:This study investigated the association of combined arthritis and diabetes, diabetes only, and arthritis only compared with neither with gait speed in the general population. This cross-sectional study included data from the second wave of Midlife in the United States-2 (MIDUS 2) project 4: Biomarker Project, 2004-200...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05370-3
更新日期：2020-08-27 00:00:00
abstract：:Familial Mediterranean fever (FMF) is an autoinflammatory disorder. It is caused by mutations in the MEFV gene encoding the pyrin protein, which regulates the innate inflammatory response. The aim of the current study was to investigate the relationship between serum Interleukin-4 (IL-4) and its gene polymorphism, nam...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-018-4214-z
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:Psoriatic arthritis (PsA) is an inflammatory disorder affecting the joints of psoriatic patients. Gelsolin regulated the actin assembly and disassembly. Reduction in plasma gelsolin levels was detected in tissue damages, including trauma, sepsis, and chronic inflammatory disorders. OBJECTIVES:The study aims...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-04959-y
更新日期：2020-06-01 00:00:00
abstract：:The population of North Dakota is predominantly of Scandinavian (Norwegian) or German descent. We analyzed a cohort of all patients diagnosed with palindromic rheumatism (PR) and followed-up (by the investigator PK) at the St. Alexius Medical Center, Specialty Clinics, Bismarck, North Dakota, from August 16, 2006 to S...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
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更新日期：2010-01-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-019-04818-5
更新日期：2020-04-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3902-4
更新日期：2018-10-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-019-04747-3
更新日期：2019-12-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/BF02243009
更新日期：1994-12-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-019-04524-2
更新日期：2019-08-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s10067-012-2022-4
更新日期：2012-09-01 00:00:00
abstract：OBJECTIVES:There are no pharmacovigilance studies on adverse event (AE) data for tumour necrosis factor alpha (TNFα) inhibitors in South Korea. We analysed AEs induced by adalimumab, infliximab, and etanercept METHODS: We used data from the Korea Institute of Drug Safety and Risk Management-Korea Adverse Events Reporti...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-019-04802-z
更新日期：2020-02-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-021-05581-2
更新日期：2021-01-12 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05515-4
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journal_title：Clinical rheumatology
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Clinical rheumatology
pub_type： 临床试验,杂志文章
doi：10.1007/BF02207657
更新日期：1991-06-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3832-1
更新日期：2018-01-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-014-2847-0
更新日期：2015-03-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-008-0842-z
更新日期：2008-06-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 临床试验,信件
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更新日期：2006-02-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-009-1097-z
更新日期：2009-04-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章,已发布勘误
doi：10.1007/s10067-018-4098-y
更新日期：2018-09-01 00:00:00
abstract：:In this study we aimed to investigate the findings in patients with adult-onset Still's disease (AOSD) admitted with fever of unknown origin (FUO) during the last 18 years in our unit, in order to discover the ratio of such patients to all patients with FUO during the same period, and to determine the clinical feature...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-002-0680-3
更新日期：2003-05-01 00:00:00
abstract：:Yao syndrome (YAOS), formerly named NOD2-associated autoinflammatory disease, is a periodic disease characterized by fever, dermatitis, polyarthritis, distal extremity swelling, and gastrointestinal and sicca-like symptoms associated with specific NOD2 sequence variants. All patients in the literature were Caucasians....
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-018-4274-0
更新日期：2018-12-01 00:00:00
