Treatment and functional outcome of patients with cystoid macular edema: a single-center experience.

Abstract:

:The aim of this study was to describe a single-center experience in the treatment and follow-up of cystoid macular edema patients. Clinical records of all patients with cystoid macular edema followed up in the Rheumatologic and Ophthalmological Unit of our center between 1993 and 2013 were retrospectively evaluated. The outcome was assessed by visual acuity and optical coherence tomography status during follow-up. Comparisons were made by Fisher's exact test (p < 0.05 significant). In this study 16 eyes in 9 patients were analyzed. Our study includes mainly post-uveitic (78 %) cases with a high prevalence of human leukocyte antigen B51 (67 %). Systemic immunosuppressive therapy was prescribed in 87 % of cases. The most frequently used drugs were cyclosporine, interferon-α, and infliximab. The first two molecules appeared respectively the most used as the first option and the one with the longest survival on treatment. Interferon-α was the most effective drug in contrasting visual acuity loss compared to the majority of drugs, but significantly more effective than mycophenolate (p = 0.01) in reducing macular edema. At the end of follow-up, 50 % of patients showed a significant visual loss, while 88 % did not present macular edema. In our small cohort, interferon-α is the most promising drug in contrasting visual acuity loss in cystoid macular edema. Visual prognosis remains severe in these patients.

journal_name

Clin Rheumatol

journal_title

Clinical rheumatology

authors

Taraborelli M,Cavazzana I,Fredi M,Airò P,Nascimbeni G,Tincani A,Franceschini F

doi

10.1007/s10067-014-2694-z

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

791-4

issue

4

eissn

0770-3198

issn

1434-9949

journal_volume

34

pub_type

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