Malnutrition and sarcopenia in a large cohort of patients with systemic sclerosis.

Abstract:

:Systemic sclerosis (SSc) is an autoimmune disease which may lead to malnutrition. Previous studies have defined it with different criteria. No thorough evaluations of sarcopenia in SSc are available. The aim of the present study was to assess the prevalence and the potential association of malnutrition and sarcopenia in a large cohort of SSc cases. A total of 141 SSc consecutive outpatients were enrolled. Body composition was analyzed by densitometry. Malnutrition was defined according to recently published ESPEN criteria, whereas sarcopenia was diagnosed in patients with reduced skeletal muscle index. Malnutrition was diagnosed in 9.2% of patients (95% CI, 4.4-14.0%). Malnourished patients had worse gastrointestinal symptoms according to UCLA SCTC GIT 2.0 questionnaire (p = 0.007), lower physical activity (p = 0.028), longer disease duration (p = 0.019), worse predicted DLCO/VA and FVC (p = 0.009, respectively), worse disease severity according to Medsger severity score (p < 0.001), lower hemoglobin (p = 0.023), and fat-free mass (p < 0.001) and were more often sarcopenic (p < 0.001). In multivariate analysis, only FVC (p = 0.006) and disease severity (p = 0.003), in particular for the lungs (p = 0.013), were confirmed to be worse in malnourished patients. Sarcopenia was diagnosed in 29\140 patients (20.7%; 95% CI, 14.0-27.4%); 11\29 were also malnourished. In multivariate analysis, sarcopenic patients had longer disease duration (p = 0.049), worse DLCO/VA (p = 0.002), and lung (p = 0.006) and skin (p = 0.014) involvement. In SSc, malnutrition defined with ESPEN criteria was found to be lower than previously reported. Sarcopenia was found to be somewhat common. Lung involvement was significantly associated with nutritional status and may not be explained only by muscle weakness.

journal_name

Clin Rheumatol

journal_title

Clinical rheumatology

authors

Caimmi C,Caramaschi P,Venturini A,Bertoldo E,Vantaggiato E,Viapiana O,Ferrari M,Lippi G,Frulloni L,Rossini M

doi

10.1007/s10067-017-3932-y

subject

Has Abstract

pub_date

2018-04-01 00:00:00

pages

987-997

issue

4

eissn

0770-3198

issn

1434-9949

pii

10.1007/s10067-017-3932-y

journal_volume

37

pub_type

杂志文章
  • Erythema nodosum and Hodgkin's disease.

    abstract::Erythema nodosum is an unusual manifestation of Hodgkin's lymphoma. One patient with long remission of Hodgkin's disease manifested persistent erythema nodosum beginning one and three months before relapse was clinically evident. So, the diagnosis of Hodgkin's disease should be considered in patients with unexplained ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/BF02114402

    authors: Taillan B,Ferrari E,Fuzibet JG,Vinti H,Pesce A,Dujardin P

    更新日期:1990-09-01 00:00:00

  • Polymyositis complicating donor lymphocyte infusion after stem cell transplantation for relapsed chronic myeloid leukemia: report of a case and review of literature.

    abstract::Polymyositis may occur along with other manifestations of chronic graft vs host disease after allogeneic bone marrow transplantation (BMT). Donor lymphocyte infusion (DLI) could produce durable remissions in relapsed patients with chronic myelogenous leukemia (CML) but it may contribute to the development of polymyosi...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-006-0346-7

    authors: Liu FC,Chen CH,Chao TY

    更新日期:2007-07-01 00:00:00

  • Pulmonary findings in Churg-Strauss syndrome in chest X-rays and high resolution computed tomography at the time of initial diagnosis.

    abstract::Churg-Strauss syndrome (CSS) is a rare, systemic, necrotizing, small- and middle-sized vessel vasculitis which is accompanied by blood eosinophilia, eosinophil infiltration of various tissues, and bronchial asthma. The lungs are the organs most often involved in CSS. The aim of this study was a retrospective evaluatio...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-010-1530-3

    authors: Szczeklik W,Sokołowska B,Mastalerz L,Grzanka P,Górka J,Pacułt K,Miszalski-Jamka T,Soja J,Musiał J

    更新日期:2010-10-01 00:00:00

  • Plasma miRNAs improve the prediction of coronary atherosclerosis in patients with rheumatoid arthritis.

    abstract:OBJECTIVE:MicroRNAs (miRNAs) regulate gene expression and are disease biomarkers. Rheumatoid arthritis (RA) patients have accelerated atherosclerosis leading to excess cardiovascular morbidity and mortality, but traditional risk factors for cardiovascular risk stratification are inadequate. In the general population, m...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-020-05573-8

    authors: Ormseth MJ,Solus JF,Sheng Q,Chen SC,Ye F,Wu Q,Oeser AM,Allen R,Raggi P,Vickers KC,Stein CM

    更新日期:2021-01-02 00:00:00

  • Venous vessel wall thickness in lower extremity is increased in male patients with Behcet's disease.

    abstract::Vascular involvement, especially in young males, is seen in up to 40% of the patients with Behcet's disease (BD) and is a major cause of mortality and morbidity. In this study, we investigated vessel wall thickness (VWT) and dilatation in lower extremity veins with Doppler ultrasound (US) in male BD patients. Sixty-on...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-019-04470-z

    authors: Alibaz-Oner F,Ergelen R,Mutis A,Erturk Z,Asadov R,Mumcu G,Ergun T,Direskeneli H

    更新日期:2019-05-01 00:00:00

  • Association between serum and synovial fluid Dickkopf-1 levels with radiographic severity in primary knee osteoarthritis patients.

    abstract::Primary knee osteoarthritis (OA) contributes to disability among middle-aged and elderly people. Dickkopf-1 (Dkk-1) and sclerostin are inhibitors of Wnt/β-catenin signaling pathway implicated in regulation of cartilage homeostasis and bone formation, respectively. We aim to investigate the association between the seru...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-017-3640-7

    authors: Theologis T,Efstathopoulos N,Nikolaou V,Charikopoulos I,Papapavlos I,Kokkoris P,Papatheodorou A,Nasiri-Ansari N,Kassi E

    更新日期:2017-08-01 00:00:00

  • Back pain following instillations of BCG for superficial bladder cancer is not a reactive complication: review of 30 Mycobacterium bovis BCG vertebral osteomyelitis cases.

    abstract::Mycobacterium bovis Bacillus Calmette-Guérin (BCG) instillations are used in bladder cancer treatment. Adverse effects can occur. Osteoarticular complications are mainly reactive arthritis, but true infections have been described, such as vertebral osteomyelitis. We made a review of M. bovis BCG vertebral osteomyeliti...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/s10067-019-04500-w

    authors: Cadiou S,Al Tabaa O,Nguyen CD,Faccin M,Guillin R,Revest M,Guggenbuhl P,Houvenagel E,Pertuiset E,Coiffier G

    更新日期:2019-06-01 00:00:00

  • Rheumatoid nodulosis: a puzzling variant of rheumatoid arthritis.

    abstract::Four patients with rheumatoid nodulosis are here described, together with a review of cases reported to date in the literature. This particular variant of rheumatoid arthritis (RA) is characterized by the presence of subcutaneous rheumatoid nodules, scanty or absent systemic manifestations and a clinically benign cour...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02207201

    authors: Goñi MA,Scheines EJ,Paira SO,Barceló HA,Maldonado Cocco JA

    更新日期:1992-09-01 00:00:00

  • Antibodies to 65Kd heat-shock protein were elevated in rheumatoid arthritis.

    abstract::Antibodies to 65Kd heat-shock protein (hsp) of mycobacterium leprae were measured by enzyme-linked immunosorbent assay (ELISA) in the three immunoglobulin classes in paired sera and synovial fluids of patients with rheumatoid arthritis (RA). Titers of anti-hsp antibody were expressed by optical density (OD) values for...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02249023

    authors: Oda A,Miyata M,Kodama E,Satoh H,Sato Y,Nishimaki T,Nomaguchi H,Kasukawa R

    更新日期:1994-06-01 00:00:00

  • COX-2-Specific inhibitors--the emergence of a new class of analgesic and anti-inflammatory drugs.

    abstract::The prostaglandin series of bioactive compounds is formed by the interaction of two distinct but related enzymes, cyclo-oxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). COX-1 is a constitutive form which is present mainly in the gastric mucosa, kidney and platelets. COX-2 is mainly an inducible form, although also to...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/s100670070024

    authors: Everts B,Währborg P,Hedner T

    更新日期:2000-01-01 00:00:00

  • Decreased interleukin-20 level in patients with systemic sclerosis: are they related with angiogenesis?

    abstract::In this study, we aimed to evaluate the relation between angiogenesis indicators and T helper 17 cytokine group in patients with systemic sclerosis (SSc) which is a disease characterized by impaired angiogenesis and autoimmune response. In our study, patients with SSc are compared with patients with primary Raynaud's ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-013-2317-0

    authors: Aydoğdu E,Pamuk ÖN,Dönmez S,Pamuk GE

    更新日期:2013-11-01 00:00:00

  • Evaluation of pulmonary function and bicycle ergometry tests in patients with Behçet's disease.

    abstract::Behçet's disease (BD) has well-defined pulmonary complications, but cardiopulmonary exercise testing and the strength of the respiratory muscles have not been studied in detail. We aimed to investigate the pulmonary functions tests, inspiratory and expiratory muscle strength and endurance, cardiopulmonary exercise tes...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-006-0508-7

    authors: Gökoğlu F,Yorgancioğlu ZR,Ustün N,Ardiç FA

    更新日期:2007-09-01 00:00:00

  • Systems to assess the progression of finger joint osteoarthritis and the effects of disease modifying osteoarthritis drugs.

    abstract::Our objective was to assess the progression of osteoarthritis (OA) using scoring systems based on the anatomical changes recorded in the finger joints on standard radiographs and to test how far these scoring systems could be used to evaluate the effects of candidate "disease modifying osteoarthritis drugs" (DMOAD). T...

    journal_title:Clinical rheumatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s10067-002-8290-7

    authors: Verbruggen G,Goemaere S,Veys EM

    更新日期:2002-06-01 00:00:00

  • Hypereosinophilia and seroconversion of rheumatoid arthritis.

    abstract::At the intersection of atopy and autoimmunity, we present a patient with seronegative rheumatoid arthritis (RA) who developed hypereosinophilia, without evidence of other etiologies, as she became rheumatoid factor (RF) positive. Although the magnitude of eosinophilia in patients with RA has been thought to reflect th...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/s10067-014-2566-6

    authors: Rosenstein RK,Panush RS,Kramer N,Rosenstein ED

    更新日期:2014-11-01 00:00:00

  • The challenges of interpreting efficacy of hip protector pads in fracture prevention in high-risk seniors.

    abstract::Efficacy of hip protector pads to prevent hip fracture is controversial. This study was done to evaluate two comparable groups for fracture risk. Two matched cohorts of long-term care residents in Canada, assessing the efficacy of hip protector pads. Evaluation included demographics, medications/diagnoses, cognition (...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-009-1115-1

    authors: Juby AG

    更新日期:2009-06-01 00:00:00

  • Chronic eosinophilic pneumonia associated with an initiation of rheumatoid arthritis.

    abstract::Although peripheral blood eosinophilia is observed in patients with active inflammatory rheumatoid arthritis (RA), RA is not a recognised cause of pulmonary eosinophilia. We describe a 55-year-old woman affected by chronic eosinophilic pneumonia (CEP) concomitantly with an initiation of RA. Both diseases responded rap...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-003-0703-8

    authors: Kwak JJ,Chang JE,Lee J,Cho YJ,Sung SH

    更新日期:2003-09-01 00:00:00

  • The effect of neutralizing antibodies on the sustainable efficacy of biologic therapies: what's in it for African and Middle Eastern rheumatologists.

    abstract::Over the last decade, biologic therapeutic proteins have advanced the treatment of diseases such as rheumatoid arthritis (RA). Therapeutic antibodies such as infliximab, adalimumab, rituximab, tocilizumab, golimumab, certolizumab pegol, the receptor construct etanercept, and abatacept, an anticluster of differentiatio...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/s10067-012-2040-2

    authors: Alawadhi A,Alawneh K,Alzahrani ZA

    更新日期:2012-09-01 00:00:00

  • Effect of ankylosing spondylitis on health-related quality of life and different aspects of social life in young patients.

    abstract::The aim of this study was to determine the emotional and sociodemographic characteristics of patients with ankylosing spondylitis (AS) and to investigate the impact of the disease on their social life and quality of life (QOL). This study included 101 patients with the diagnosis of AS. All patients filled in a questio...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-005-1150-5

    authors: Ozgül A,Peker F,Taskaynatan MA,Tan AK,Dinçer K,Kalyon TA

    更新日期:2006-03-01 00:00:00

  • Efficacy of febuxostat versus allopurinol and the predictors of achieving target serum urate in a cohort of Thai people with gout.

    abstract:OBJECTIVE:The objectives of our study were to compare the efficacy of febuxostat with allopurinol in Thai subjects with gout, as well as to determine the predictive factors of responsiveness to urate-lowering agents and to evaluate the safety of febuxostat in a real-world setting. METHODS:The study was a retrospective...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-020-05262-6

    authors: Lertnawapan R,Jatuworapruk K

    更新日期:2021-01-01 00:00:00

  • HLA B27 and clinical features in Reiter's syndrome.

    abstract::HLA B27 and other clinical findings were investigated in 18 Turkish patients with Reiter's syndrome (mean age 35.8 +/- 8.09). Male/female ratio was 2/1. All 18 patients were seronegative, 12 (66.6%) presenting with an asymmetrical oligoarticular arthritis. Radiological sacroiliitis and enthesopathy was found in 9 (50%...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02207965

    authors: Tuncer T,Arman MI,Akyokus A,Bütün B,Unal S

    更新日期:1992-06-01 00:00:00

  • The spectrum and clinical significance of myositis-specific autoantibodies in Chinese patients with idiopathic inflammatory myopathies.

    abstract:OBJECTIVES:The aim of this study is to analyze the prevalence of myositis-specific autoantibodies (MSAs) and to elucidate their associations with clinical features in Chinese patients with polymyositis (PM) and dermatomyositis (DM). METHODS:Twelve subsets of MSAs including anti-Mi-2, anti-TIF1-γ, anti-MDA5, anti-NXP2,...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-019-04503-7

    authors: Li S,Ge Y,Yang H,Wang T,Zheng X,Peng Q,Lu X,Wang G

    更新日期:2019-08-01 00:00:00

  • The validity and reliability of the Turkish version of the Revised Fibromyalgia Impact Questionnaire.

    abstract::The Revised Fibromyalgia Impact Questionnaire (FIQR) attempts to address the limitations of the Fibromyalgia Impact Questionnaire (FIQ). As there is no Turkish version of the FIQR available, we aimed to investigate the validity and reliability of a Turkish translation of the FIQR in Turkish female fibromyalgia (FM) pa...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-010-1546-8

    authors: Ediz L,Hiz O,Toprak M,Tekeoglu I,Ercan S

    更新日期:2011-03-01 00:00:00

  • Inflammation and shoulder pain--a perspective on rotator cuff disease, adhesive capsulitis, and osteoarthritis: conservative treatment.

    abstract::Shoulder pain may occur as a secondary symptom to a wide range of conditions, including rotator cuff disorders, glenohumeral osteoarthritis, or adhesive capsulitis. One common factor linking these diseases is inflammation. Understanding the role of inflammation in shoulder disorders can help physicians to manage and t...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,收录出版,评审

    doi:10.1007/s10067-009-1109-z

    authors: Saccomanni B

    更新日期:2009-05-01 00:00:00

  • Prevalence of soluble peptidylarginine deiminase 4 (PAD4) and anti-PAD4 antibodies in autoimmune diseases.

    abstract::The objectives of this study are to investigate the prevalence of PAD4 and anti-PAD4 antibodies (Abs) in autoimmune diseases and to clarify their association with anticitrullinated protein antibodies (ACPAs) and shared epitope (SE) in patients with rheumatoid arthritis (RA). Levels of human PAD4 and anti-PAD4 Abs in s...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-015-3082-z

    authors: Umeda N,Matsumoto I,Kawaguchi H,Kurashima Y,Kondo Y,Tsuboi H,Ogishima H,Suzuki T,Kagami Y,Sakyu T,Ishigami A,Maruyama N,Sumida T

    更新日期:2016-05-01 00:00:00

  • Studies on psoriatic osteopathy.

    abstract::To demonstrate an as yet merely postulated generalized osteopathy in psoriatics, the serum calcium level, the alkaline phosphatase in the serum and the urinary excretion of hydroxyproline were evaluated in 24 patients with Ps and 24 patients with PA. Moreover, the bone bioptates from 25 patients with PA and 10 patient...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02208026

    authors: Hein G,Abendroth K,Müller A,Wessel G

    更新日期:1991-03-01 00:00:00

  • Pregnancy in systemic lupus erythematosus: a retrospective study from a developing community.

    abstract::Little data exists from the developing world on pregnancy in systemic lupus erythematosus (SLE). A 10-year review of pregnancies in lupus patients was conducted at a tertiary hospital in a developing country. Forty-seven pregnancies in 31 patients were identified. Eleven (23%) booked after 20 weeks gestation. There we...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-007-0749-0

    authors: Whitelaw DA,Hall D,Kotze T

    更新日期:2008-05-01 00:00:00

  • Successful treatment of hypertrophic pachymeningitis in refractory Wegener's granulomatosis with rituximab.

    abstract::Central nervous involvement (CNS) is uncommon manifestation of Wegener's granulomatosis (WG). We are describing a patient with refractory WG with CNS involvement which responded to rituximab. This lady presented with nodular scleritis. Three months later, she developed headache, vision loss with complete opthalmoplegi...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-009-1291-z

    authors: Sharma A,Kumar S,Wanchu A,Lal V,Singh R,Gupta V,Singh S,Gupta A

    更新日期:2010-01-01 00:00:00

  • Detection of asymptomatic cranial neuropathies in patients with systemic lupus erythematosus and their relation to antiribosomal P antibody levels and disease activity.

    abstract::The objectives of this study are to assess the risk of asymptomatic cranial neuropathy among patients with systemic lupus erythematosus (SLE) and find any association with disease activity and antiribosomal P antibodies. This study is a case-control study including 60 female patients and 30 healthy female controls. Di...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-014-2679-y

    authors: Gaber W,Ezzat Y,El Fayoumy NM,Helmy H,Mohey AM

    更新日期:2014-01-01 00:00:00

  • Chagas disease reactivation in rheumatologic patients: association with immunosuppressive therapy and humoral response.

    abstract::Evidence for Chagas disease reactivation (CDR) in rheumatologic patients under rheumatologic treatments (RTs) is scarce. To screen and follow-up patients with rheumatic diseases and concomitant Chagas disease under RT to detect CDR and to describe a possible relationship between CDR and specific RT. An observational, ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-021-05581-2

    authors: Ringer A,Ruffino JP,Leiva R,Cuadranti N,Argento MC,Martínez MF,Rolla I,Chulibert S,Carbone D,Palatnik M,Cortese MN,Lagrutta M,Córdoba L,González FB,Pacini MF,Villar SR,Águila D,Bottasso OA,Pérez AR,Abdala M

    更新日期:2021-01-12 00:00:00

  • Esophageal high-resolution impedance manometry alterations in asymptomatic patients with systemic sclerosis: prevalence, associations with disease features, and prognostic value.

    abstract::This study aims to investigate pre-clinical esophageal involvement in systemic sclerosis (SSc) by high-resolution impedance manometry (HRiM), its associations with disease features including lung involvement, and its predictivity of esophageal symptoms overtime. Charts of 45 asymptomatic (no heartburn/regurgitation/dy...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-018-4026-1

    authors: Vettori S,Tolone S,Capocotta D,Chieffo R,Giacco V,Valentini G,Docimo L

    更新日期:2018-05-01 00:00:00