Abstract:
:Central nervous involvement (CNS) is uncommon manifestation of Wegener's granulomatosis (WG). We are describing a patient with refractory WG with CNS involvement which responded to rituximab. This lady presented with nodular scleritis. Three months later, she developed headache, vision loss with complete opthalmoplegia, and relative afferent papillary defect. The brain MRI showed thickened dura along ant temporal region and enlargement of right cavernous sinus. C ANCA and PR 3 ELISA were positive. Non-contrast CT scan of orbit and paranasal sinuses showed soft tissue swelling of the right orbit along with mucosal thickening of right maxillary sinus. There were bilateral upper lobe nodules on HRCT of the chest. She responded to 3 days of methylprednisolone pulses and 1 g pulse cyclophosphamide but had multiple relapses while receiving high dose oral steroids and pulse cyclophosphamide. Then she was given four infusions of rituximab (375 mg/m(2)) at one-weekly interval. She had complete remission following rituximab. She relapsed after 6 months but again responded to repeat rituximab infusion.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Sharma A,Kumar S,Wanchu A,Lal V,Singh R,Gupta V,Singh S,Gupta Adoi
10.1007/s10067-009-1291-zsubject
Has Abstractpub_date
2010-01-01 00:00:00pages
107-10issue
1eissn
0770-3198issn
1434-9949journal_volume
29pub_type
杂志文章abstract::Functional limitation is often complained by patients with ankylosing spondylitis (AS). With a rising number of patients suffering from AS, there are a limited number of reports focusing on functional limitation of AS in Chinese patients. This study was conducted to investigate the level of functional limitation and e...
journal_title:Clinical rheumatology
pub_type: 杂志文章
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journal_title:Clinical rheumatology
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journal_title:Clinical rheumatology
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pub_type: 临床试验,杂志文章
doi:10.1007/BF02201028
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1999-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2005-06-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/BF02114402
更新日期:1990-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-05-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2013-11-01 00:00:00