Abstract:
:In order to assess the clinical equivalence between deflazacort oral drops and tablets, 18 patients with active rheumatoid arthritis were enrolled in an open, controlled, randomised ('tablets --> drops' sequence, or vice versa), two-period (21 days each) crossover trial (from tablets to drops, or vice versa). Individual dose titration of deflazacort drops or tablets was made weekly on the basis of clinical need. Primary outcome measures of efficacy were changes in the joint swelling count (JSC), erythrocyte sedimentation rate (ESR), hand-grip strength (HGS), joint pain (JP), duration of morning stiffness (MS), physician's global evaluation and patient's self-assessment. Sixteen patients were available by the end of the study. The formulations were equivalent with respect to HGS and improvement in duration of MS, and close to equivalence with respect to JSC and ESR decrease; the drops seemed to be more effective than tablets with respect to JP reduction. No differences between the two formulations were observed with respect to physician's and patient's assessment. The minimum effective dose of each preparation and the relative potency ratio were also established. Drops and tablets were found to have the same potency.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Di Munno O,Mazzantini M,Milani S,Pasero Gdoi
10.1007/s100670050072subject
Has Abstractpub_date
1999-01-01 00:00:00pages
140-4issue
2eissn
0770-3198issn
1434-9949journal_volume
18pub_type
临床试验,杂志文章,随机对照试验abstract::Takayasu's arteritis (TA) is a chronic inflammation that frequently involves the aorta and its major branches. The clinical features of TA vary in different ethnic populations. The objective of this study is to characterize the clinical features, angiographic findings, and response to treatment of patients with TA in ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-010-1496-1
更新日期:2010-09-01 00:00:00
abstract::Sjögren's syndrome is characterized serologically by the presence of autoantibodies against Ro/SS-A and La/SS-B. The mechanisms by which these autoantibodies arise is not clear at this moment. B cells capable of producing antibodies to Ro/SS-A and La/SS-B seem to be present in every individual; whether or not an indiv...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/BF03342632
更新日期:1995-07-01 00:00:00
abstract::The aim of this study was to describe the abnormalities identified with conventional MRI in children with neuropsychiatric systemic lupus erythematosus (NPSLE). This was single-centre (Great Ormond Street Hospital, London) retrospective case series of patients with juvenile NPSLE seen in 2003-2013. Brain MR images of ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-016-3376-9
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVES:To establish the prevalence of the associated secondary diseases in patients with Raynaud's phenomenon (RP) attending a rheumatology specialty centre and to determine the frequency with which a secondary illness develops in those having RP, in absence of a well-defined secondary cause. METHODS:118 consecuti...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-003-0726-1
更新日期:2003-10-01 00:00:00
abstract::The aim of our study was to explore the relationship between circulating T cells and ankylosing spondylitis (AS) and to find the role of the CD8+CD122+ T cells in the pathogenesis and progression of AS. With the method of case-control design, flow cytometry was performed to quantitatively determine the percentage of c...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3887-z
更新日期:2018-03-01 00:00:00
abstract::Articular involvement is described in a 58-year-old female patient with scleroderma. Radiological findings included intra-articular calcification, destructive osteoarthritis and selective involvement of the first metacarpal base. The discussion attempts to explain the way in which intra-articular calcification and ost...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02032338
更新日期:1984-09-01 00:00:00
abstract::Fourteen patients with ankylosing spondylitis (AS) were treated in a pilot study for two weeks at a Tiberias spa with a combination of hot mineral water baths and mud packs. A significant improvement was noticed in morning stiffness, finger to floor distance and the overall well-being assessment both by the patient an...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02208080
更新日期:1995-01-01 00:00:00
abstract::Two cases of late hypophosphatemic osteomalacia are described: a male aged 30 who had the disease since he was 22 and a woman of 23 who had the disease since she was 14. Both presented with myopathy and bone pain, and showed hypophosphatemia, hyperglycinuria, reduced tubular phosphate reabsorption (TPR), increased hyd...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02031617
更新日期:1985-09-01 00:00:00
abstract::Survival and outcomes have improved considerably among patients with juvenile dermatomyositis (JDM) in the west. However, mortality continues to be high in the developing world. There is paucity of literature on this aspect of JDM from developing countries. We reviewed case files of all patients with JDM registered in...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-014-2747-3
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVES:The invalidation or social pain is an important but neglected issue in polysymptomatology of fibromyalgia (FM). This study sought whether tracing-perceived invalidation could be effective to discriminate between the presence and absence of FM in chronic pain patients with respect to five different sources, i...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05515-4
更新日期:2021-01-07 00:00:00
abstract::A 61-year-old female with a history of vaginal dryness, Raynaud's phenomenon, xerostomia and xerophthalmia presented with exertional dyspnoea and weakness. Laboratory and instrumental examinations enabled us to make the diagnosis of primary Sjögren's syndrome, while cardiologic and imaging investigations evidenced iso...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-004-1071-8
更新日期:2005-08-01 00:00:00
abstract::Over the last decade, biologic therapeutic proteins have advanced the treatment of diseases such as rheumatoid arthritis (RA). Therapeutic antibodies such as infliximab, adalimumab, rituximab, tocilizumab, golimumab, certolizumab pegol, the receptor construct etanercept, and abatacept, an anticluster of differentiatio...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-012-2040-2
更新日期:2012-09-01 00:00:00
abstract::The aim of the study was to investigate the pulmonary parenchymal abnormalities by high resolution computed tomography (HRCT) in patients with various forms of scleroderma. Three scans were performed sequentially in all cases: one at the level of aortic arch, one at the tracheal carina and one 1-2 cm above the diaphra...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02207928
更新日期:1995-11-01 00:00:00
abstract::To present the clinical and pathological findings in patients presenting with myositis caused by syphilis. The literature is reviewed, and pathophysiologic factors discussed. A 49-year-old Caucasian heterosexual male with a known history of stable human immunodeficiency virus (HIV) and hepatitis C (HCV) co-infection, ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-010-1668-z
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVES:To compare the efficacy and safety of tocilizumab with those of abatacept in patients with active rheumatoid arthritis not responding to anti-tumor necrosis factor therapy. METHODS:A prospective, open-label study was carried out on adult females with moderate-to-severe rheumatoid arthritis. Patients were ra...
journal_title:Clinical rheumatology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10067-019-04508-2
更新日期:2019-08-01 00:00:00
abstract::Children with juvenile idiopathic arthritis (JIA) may infrequently present with localized anterior knee pain or swelling, in addition to generalize knee pain induced by JIA. We report five cases of deep infrapatellar bursitis in children with JIA. The clinical features, radiological findings, management, and outcome o...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-010-1620-2
更新日期:2011-02-01 00:00:00
abstract::There is an increasing concern over generalizability of trial results. We investigated eligibility criteria of knee osteoarthritis clinical trials. Eligible trials were randomized, placebo-controlled trials that were identified by searches in MEDLINE, SCOPUS, and the Cochrane Central Register of Controlled Trials. We ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-013-2342-z
更新日期:2013-11-01 00:00:00
abstract::rs2431697 is located on 5q33.3, between pituitary tumor-transforming gene 1 and miR-146a. Several studies have estimated the association between rs2431697 and systemic lupus erythematosus risk. However, the results were inconsistent. A case-control study was carried out to explore the association between rs2431697 and...
journal_title:Clinical rheumatology
pub_type: 杂志文章,meta分析
doi:10.1007/s10067-015-3045-4
更新日期:2015-11-01 00:00:00
abstract::Clinical guidelines regarding anti-viral prophylaxis for HBV surface antigen (HBsAg) carriers starting anti-TNFα agents are not yet fully established, even in endemic regions of HBV infection. We retrospectively collected the clinical data of 52 HBsAg carriers with rheumatoid arthritis (RA) or ankylosing spondylitis (...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-012-1960-1
更新日期:2012-06-01 00:00:00
abstract::CD30/CD30L and CD40/CD40L are molecules from the tumor necrosis factor (TNF) superfamily. They have a major effect on communications between the B and T cells, which leads to control of maturation, proliferation, and apoptosis of those cells. The aim of this study was to compare the levels of a soluble form of CD30 (s...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-006-0389-9
更新日期:2007-05-01 00:00:00
abstract::In the past decade, lung ultrasound (LUS) B-lines and serum Krebs von den Lungen-6 (KL-6) antigen have been recognized as biomarkers of the connective tissue disease-associated interstitial lung diseases (CTD-ILDs). Robust data have demonstrated that B-lines total numbers and KL-6 levels are correlated with high-resol...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-019-04462-z
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:To determine clinical course and outcomes in rheumatic disease patients with coronavirus disease 2019 (COVID-19) and compare results to uninfected patients. METHODS:We conducted a case cohort study of autoimmune disease patients with COVID-19 (confirmed by severe acute respiratory syndrome coronavirus 2 PCR)...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-021-05578-x
更新日期:2021-01-09 00:00:00
abstract::Erythema nodosum is an unusual manifestation of Hodgkin's lymphoma. One patient with long remission of Hodgkin's disease manifested persistent erythema nodosum beginning one and three months before relapse was clinically evident. So, the diagnosis of Hodgkin's disease should be considered in patients with unexplained ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/BF02114402
更新日期:1990-09-01 00:00:00
abstract::Rheumatoid arthritis (RA) is well known to affect many different organ systems. Previous work suggests that this includes the auditory system and that measures of hearing may be related to indices of RA disease activity. The aims of this study were to determine whether hearing loss in young subjects with rheumatoid ar...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-007-0802-z
更新日期:2008-05-01 00:00:00
abstract::We describe two patients with pancreatitis. One patient had acute pancreatitis of biliary origin and presented with small joint polyarthritis and panniculitis lesions. The other patient was originally hospitalised for dyspnoea with bilateral pleural effusion, and subsequently developed migratory polyarthritis. During ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF01451017
更新日期:1998-01-01 00:00:00
abstract::In addition to juxtaarticular osteoporosis, which appears to reflect predominantly local disease mechanisms, more generalized bone loss can occur in rheumatoid arthritis (RA). The aim of this study was to compare bone mineral density (BMD) of the lumbar spine and proximal femur in RA patients versus controls and evalu...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02207677
更新日期:1995-07-01 00:00:00
abstract::Autonomic nervous system (ANS) involvement has been studied in systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, Sjogren's syndrome, and ankylosing spondylitis but still has not been studied in psoriatic arthritis (PsA). The aim of this study was to investigate the prevalence and the nature of au...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-013-2239-x
更新日期:2013-07-01 00:00:00
abstract::Subcutaneous rheumatoid nodules occur commonly in advanced cases of rheumatoid arthritis and are the most common extra-articular lesion of this disease. We present a case of a very unusual giant rheumatoid nodule that developed on the lateral side of a knee. The case was devoid of systemic symptoms of arthritis and th...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-004-0926-3
更新日期:2004-10-01 00:00:00
abstract::This study aimed to compare the diagnostic value of ultrasonography to conventional radiography in detecting osteophytes and erosions in the midfoot joints in patients suffering from inflammatory and non-inflammatory joint disease. Patients with current foot radiographs were included and stratified in two cohorts: inf...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3658-x
更新日期:2017-09-01 00:00:00
abstract::Sustained cough is a frequent complaint in methotrexate (MTX) treatment for rheumatoid arthritis and can be a symptom of incipient MTX-induced pneumonitis. This study was performed to characterize MTX-associated cough clinically and to clarify by which means this condition can be distinguished from incipient MTX pneum...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02229707
更新日期:1996-05-01 00:00:00