Sustained cough in methotrexate therapy for rheumatoid arthritis.

Abstract:

:Sustained cough is a frequent complaint in methotrexate (MTX) treatment for rheumatoid arthritis and can be a symptom of incipient MTX-induced pneumonitis. This study was performed to characterize MTX-associated cough clinically and to clarify by which means this condition can be distinguished from incipient MTX pneumonitis. Three patients with MTX-induced pneumonitis and 10 patients with sustained cough unassociated with pneumonitis were examined clinically, by pulmonary function testing, and bronchoalveolar lavage (BAL). In MTX pneumonitis, cough was associated with progressive dyspnoea, constitutional symptoms, impaired pulmonary function, and interstitial infiltration of variable degree by chest X-ray. BAL cytology invariably showed lymphocytic alveolitis while transbronchial biopsy revealed active interstitial inflammation in only one patient. Ten patients had sustained, nonprogressive cough in the absence of constitutional symptoms, progressive dyspnoea and impaired pulmonary function. Neither X-ray nor BAL nor transbronchial biopsy revealed any evidence of interstitial lung disease. In the majority of these patients, cough abated with symptomatic treatment with or without temporary discontinuation of MTX. It is concluded that MTX-associated cough can be a reflection of isolated airway disease. Clinically, absence of constitutional symptoms, impaired pulmonary function, and interstitial infiltration on X-ray distinguished this condition from incipient MTX pneumonitis. Cough without pulmonary parenchymal involvement appears to result from an irritant effect of MTX on the airways.

journal_name

Clin Rheumatol

journal_title

Clinical rheumatology

authors

Schnabel A,Dalhoff K,Bauerfeind S,Barth J,Gross WL

doi

10.1007/BF02229707

subject

Has Abstract

pub_date

1996-05-01 00:00:00

pages

277-82

issue

3

eissn

0770-3198

issn

1434-9949

journal_volume

15

pub_type

杂志文章
  • Mean platelet volume as an indicator of disease activity in juvenile SLE.

    abstract::The aim of the study was to assess mean platelet volume (MPV) in children with systemic lupus erythematosus (SLE) at the active and inactive stages. Twenty children with SLE and 30 age- and gender-matched controls were enrolled. Demographic data, SLE disease activity index (SLEDAI), erythrocyte sedimentation rate (ESR...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-014-2540-3

    authors: Yavuz S,Ece A

    更新日期:2014-05-01 00:00:00

  • A case report of tumor necrosis factor-alpha antibody-induced thrombocytopenia associated with emerging IgM anticardiolipin antibody in patients with scleroderma overlap/rheumatoid arthritis.

    abstract::It is commonly believed that infliximab-induced anticardiolipin antibody belongs to the IgM subclass but not the IgG subclass and that the IgM subclass could not produce clinical symptoms. However, we had a patient with scleroderma overlap/rheumatoid arthritis who developed thrombocytopenia associated with the appeara...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-006-0229-y

    authors: Hamaguchi M,Kawahito Y,Ishino H,Yoshida M,Yoshikawa T

    更新日期:2007-06-01 00:00:00

  • Anxiety and depression in adult-onset Still's disease patients and associations with health-related quality of life.

    abstract:OBJECTIVE:Adult-onset Still's disease (AOSD) is an autoinflammatory disorder leading to multiorgan involvements. We sought to investigate mood status and the health-related quality of life (HRQoL) in these patients. METHODS:In this study, 82 AOSD patients and 82 age- and sex-matched healthy controls were included. Dem...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-020-05094-4

    authors: Chi H,Jin H,Wang Z,Feng T,Zeng T,Shi H,Wu X,Wan L,Teng J,Sun Y,Liu H,Cheng X,Ye J,Hu Q,Zhou Z,Gu J,Jia J,Liu T,Qiao X,Yang C,Su Y

    更新日期:2020-12-01 00:00:00

  • Circulating levels of interleukin-6, vascular endothelial growth factor, YKL-40, matrix metalloproteinase-3, and total aggrecan in spondyloarthritis patients during 3 years of treatment with TNFα inhibitors.

    abstract::The objectives of the study were to investigate short and long-term changes and relations to treatment response of plasma interleukin-6 (IL-6), vascular endothelial growth factor (VEGF), YKL-40, matrix metalloproteinase-3 (MMP-3), and total aggrecan in patients with spondyloarthritis (SpA) treated with tumor necrosis ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-010-1528-x

    authors: Pedersen SJ,Hetland ML,Sørensen IJ,Ostergaard M,Nielsen HJ,Johansen JS

    更新日期:2010-11-01 00:00:00

  • Ochronosis: a case of severe ochronotic arthropathy.

    abstract::Ochronosis involves primarily the large cartilaginous joint surfaces, ribs, intervertebral discs, ear cartilage etc. We report on a 53-year-old woman with typical alkaptonuric ochronosis with dark urine, blue-black pigmentation of the auriculae and hands, focal brown hyperpigmentation of the sclera, spondylarthropathy...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-002-8277-4

    authors: Nas K,Gür A,Akdeniz S,Cevik R,Harman M,Saraç AJ

    更新日期:2002-05-01 00:00:00

  • Association of tumor necrosis factor-α (G-308A) genetic variant with matrix metalloproteinase-9 activity and joint destruction in early rheumatoid arthritis.

    abstract::Matrix metalloproteinases (MMPs) are the key enzymes responsible for the joint destruction. Their activity is regulated by the level of proinflammatory cytokines. The aim of this study was to examine the impact of TNF-α G-308A polymorphism on MMP-9 levels in blood plasma (BP) and synovial fluid (SF) of patients with r...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-017-3699-1

    authors: Stojanovic S,Bojana Stamenkovic,Stoimenov TJ,Nedovic J,Zivkovic V,Despotovic M,Pavlovic D

    更新日期:2017-07-01 00:00:00

  • Peripheral neuropathy, polymyalgia and arthralgia: a paraneoplastic syndrome associated with myeloma.

    abstract::We describe a patient with peripheral neuropathy, polymyalgia, arthralgia and cervical vertebral osteosclerosis who was subsequently diagnosed to have fatal multiple myeloma with IgG gammopathy and lambda urinary chains. The initial presentation and clinical features are discussed. ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02031978

    authors: Samanta A,Hilton D,Roy S

    更新日期:1990-06-01 00:00:00

  • Efficacy of transforaminal versus interspinous corticosteroid injectionin discal radiculalgia - a prospective, randomised, double-blind study.

    abstract::A prospective, randomised, double-blind study was carried out to compare the respective efficacies of transforaminal and interspinous epidural corticosteroid injections in discal radiculalgia. Thirty-one patients (18 females, 13 males) with discal radicular pain of less than 3 months' duration were consecutively rando...

    journal_title:Clinical rheumatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s10067-003-0736-z

    authors: Thomas E,Cyteval C,Abiad L,Picot MC,Taourel P,Blotman F

    更新日期:2003-10-01 00:00:00

  • GITRL is associated with increased autoantibody production in patients with rheumatoid arthritis.

    abstract::The study aimed to determine the serum level of glucocorticoid-induced tumor necrosis factor receptor family-related protein ligand (GITRL) in patients with rheumatoid arthritis (RA) and investigate its clinical significance. GITRL levels were measured by enzyme-linked immunosorbent assay (ELISA) in 88 RA patients, 20...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-016-3280-3

    authors: Li L,Wen W,Jia R,Li Y,Liu X,Sun X,Li Z

    更新日期:2016-09-01 00:00:00

  • Evening primrose oil and olive oil in treatment of rheumatoid arthritis.

    abstract::The effects of 10 ml of evening primrose oil or olive oil, administered twice daily for 12 weeks, on clinical and laboratory signs and on plasma prostaglandins were studied in 18 patients with rheumatoid arthritis. The plasma concentration of PGE2 decreased and that of TxB2 increased in both treatment groups, but no s...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02030080

    authors: Jäntti J,Seppälä E,Vapaatalo H,Isomäki H

    更新日期:1989-06-01 00:00:00

  • Ultrasound-guided procedure for the treatment of trapeziometacarpal osteoarthritis.

    abstract::Initial treatment of trapeziometacarpal osteoarthritis (TMO) often consists of intra-articular injection of corticosteroids or hyaluronic acid. Several studies have shown that ultrasound (US)-guided injections demonstrate greater precision and effectiveness when compared to blind techniques. The aim of our study was t...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-011-1730-5

    authors: Di Sante L,Cacchio A,Scettri P,Paoloni M,Ioppolo F,Santilli V

    更新日期:2011-09-01 00:00:00

  • Clinical equivalence between deflazacort oral drops and tablets in active rheumatoid arthritis.

    abstract::In order to assess the clinical equivalence between deflazacort oral drops and tablets, 18 patients with active rheumatoid arthritis were enrolled in an open, controlled, randomised ('tablets --> drops' sequence, or vice versa), two-period (21 days each) crossover trial (from tablets to drops, or vice versa). Individu...

    journal_title:Clinical rheumatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s100670050072

    authors: Di Munno O,Mazzantini M,Milani S,Pasero G

    更新日期:1999-01-01 00:00:00

  • Activation status of CD56dim natural killer cells is associated with disease activity of patients with systemic lupus erythematosus.

    abstract:OBJECTIVES:Decreased natural killer (NK) cells have been reported in systemic lupus erythematosus (SLE) patients. However, the role of NK cells in the pathogenesis of SLE is not well understood. In this study, we aimed to characterize NK cell subsets, phenotypes, and cytokine-secreting functions and investigate the cli...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-020-05306-x

    authors: Liu M,Liu J,Zhang X,Xiao Y,Jiang G,Huang X

    更新日期:2020-08-14 00:00:00

  • Comparison of signal detection of tumour necrosis factor-α inhibitors using the Korea Adverse Events Reporting System Database, 2005-2016.

    abstract:OBJECTIVES:There are no pharmacovigilance studies on adverse event (AE) data for tumour necrosis factor alpha (TNFα) inhibitors in South Korea. We analysed AEs induced by adalimumab, infliximab, and etanercept METHODS: We used data from the Korea Institute of Drug Safety and Risk Management-Korea Adverse Events Reporti...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-019-04802-z

    authors: Ha D,Lee SE,Song I,Lim SJ,Shin JY

    更新日期:2020-02-01 00:00:00

  • Bilateral central retinal vein thrombosis in Behçet's disease.

    abstract::Behçet's disease is a multisystem disorder affecting the skin, mucous membranes, eye, joints, central nervous system, and blood vessels. One of the known vascular complications of Behçet's disease is venous thrombosis or aneurysm formation. We report, herewith, a patient with Behçet's disease who developed radial arte...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02229654

    authors: el-Asrar AM,al-Momen AK,Alamro SA,Gader AG,Tabbara KF

    更新日期:1996-09-01 00:00:00

  • Urticaria as a presenting manifestation of adult-onset Still's disease.

    abstract::Adult-onset Still's disease (AOSD) is a rare disorder of unknown aetiology, characterised by high spiking fever, an evanescent, erythematous, maculopapular rash, arthralgia or arthritis, lymphadenopathy, hepatosplenomegaly, sore throat and serositis. It is associated with marked leukocytosis, high erythrocyte sediment...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s100670070034

    authors: Salaffi F,Filosa G,Bugatti L,Maestrini MD

    更新日期:2000-01-01 00:00:00

  • Fungal arthritis of the knee caused by Mycoleptodiscus indicus.

    abstract::Mycoleptodiscus indicus is a recognized plant pathogen which has very rarely been reported as a cause of human infection. It is a tropical or subtropical fungus which is difficult to culture and identify from clinical specimens. This is the first report of septic arthritis with this fungus in a healthy Canadian male. ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-010-1448-9

    authors: Dewar CL,Sigler L

    更新日期:2010-09-01 00:00:00

  • Systemic sclerosis is associated with knee arthroplasty outcomes: a National US study.

    abstract:OBJECTIVE:To assess whether systemic sclerosis (SSc) is associated with total knee arthroplasty (TKA) outcomes. METHODS:We used the 1998-2014 US National Inpatient Sample. We conducted multivariable-adjusted logistic regression analyses to examine the association of a diagnosis of SSc with post-TKA in-hospital complic...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-019-04754-4

    authors: Singh JA,Cleveland JD

    更新日期:2020-01-01 00:00:00

  • Inflammation and shoulder pain--a perspective on rotator cuff disease, adhesive capsulitis, and osteoarthritis: conservative treatment.

    abstract::Shoulder pain may occur as a secondary symptom to a wide range of conditions, including rotator cuff disorders, glenohumeral osteoarthritis, or adhesive capsulitis. One common factor linking these diseases is inflammation. Understanding the role of inflammation in shoulder disorders can help physicians to manage and t...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,收录出版,评审

    doi:10.1007/s10067-009-1109-z

    authors: Saccomanni B

    更新日期:2009-05-01 00:00:00

  • The effect of anti-TNF agent on oxidation status in patients with ankylosing spondylitis.

    abstract::The aim of this study was to comparatively evaluate oxidative status of ankylosing spondylitis (AS) patients receiving anti-tumor necrosis factor (TNF) or non-steroid anti-inflammatory drugs (NSAID). Forty-seven patients with AS and 27 healthy controls were enrolled. Of these, 23 were on anti-TNF (group 1) and 24 on N...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-009-1325-6

    authors: Karkucak M,Capkin E,Alver A,Akyuz A,Kiris A,Ak E,Topbas M,Tosun M

    更新日期:2010-03-01 00:00:00

  • Imaging of the seronegative anterior chest wall (ACW) syndromes.

    abstract::The sternocostoclavicular (SCC) region is subject to the same diseases that occur in joints, with congenital and developmental anomalies, inflammatory and infectious diseases, soft tissue and bone tumors as well as the seronegative spondyloarthropathies, including ankylosing spondylitis, reactive arthritis, enteropath...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/s10067-008-0905-1

    authors: Guglielmi G,Scalzo G,Cascavilla A,Salaffi F,Grassi W

    更新日期:2008-07-01 00:00:00

  • Combination therapy with cyclosporine A and anti-TNF-alpha agents in the treatment of rheumatoid arthritis and concomitant hepatitis C virus infection.

    abstract::We describe two cases of rheumatoid arthritis (RA) patients and concomitant hepatitis C virus infection (HCV), treated with cyclosporine A (CsA) and anti-TNF-alpha agents. SGOT/SGPT and HCV-RNA serum levels remained unchanged longer than 1 year of treatment. No side effects were registered. We suggest that combination...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-006-0412-1

    authors: Bellisai F,Giannitti C,Donvito A,Galeazzi M

    更新日期:2007-07-01 00:00:00

  • Functioning and health-related quality of life in Chinese patients with systemic sclerosis: a case-control study.

    abstract::The objective of the study was to study the functioning and health-related quality of life (HRQoL) in patients with systemic sclerosis (SSc) and its associated factors. Consecutive SSc patients and an equal number of age- and gender-matched healthy controls were recruited for the assessment of functioning and HRQoL by...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-014-2525-2

    authors: Chan PT,Mok CC,Chan KL,Ho LY

    更新日期:2014-05-01 00:00:00

  • PASE and EARP questionnaires for the identification of enthesitis, synovitis, and tenosynovitis in patients with psoriasis.

    abstract::The aim of this study was to assess the diagnostic value of the Psoriatic Arthritis Screening Evaluation (PASE) and Early Psoriatic Arthritis Screening Questionnaire (EARP) questionnaires in the ultrasonographic detection of enthesitis, synovitis, and tenosynovitis. A cross-sectional study was done in a total of 96 co...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-016-3392-9

    authors: Vidal D,Reina D,Martin JL,Cerdà D,Estrada P,García-Diaz S,Navarro V,Peramiquel L,Roig D,Torrente V,Corominas H

    更新日期:2016-10-01 00:00:00

  • The spectrum and clinical significance of myositis-specific autoantibodies in Chinese patients with idiopathic inflammatory myopathies.

    abstract:OBJECTIVES:The aim of this study is to analyze the prevalence of myositis-specific autoantibodies (MSAs) and to elucidate their associations with clinical features in Chinese patients with polymyositis (PM) and dermatomyositis (DM). METHODS:Twelve subsets of MSAs including anti-Mi-2, anti-TIF1-γ, anti-MDA5, anti-NXP2,...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-019-04503-7

    authors: Li S,Ge Y,Yang H,Wang T,Zheng X,Peng Q,Lu X,Wang G

    更新日期:2019-08-01 00:00:00

  • Combined diabetes and arthritis are associated with declined gait speed.

    abstract::This study investigated the association of combined arthritis and diabetes, diabetes only, and arthritis only compared with neither with gait speed in the general population. This cross-sectional study included data from the second wave of Midlife in the United States-2 (MIDUS 2) project 4: Biomarker Project, 2004-200...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-020-05370-3

    authors: Alenazi AM,Alshehri MM,Alqahtani BA,Alanazi AD,Bindawas SM

    更新日期:2020-08-27 00:00:00

  • Severity of symptoms persists for decades in fibromyalgia-a 26-year follow-up study.

    abstract::The aim of this study is to find out the outcome of 28 patients who got the diagnosis of primary fibromyalgia (pFM) 26 years ago. In 1986, 56 patients with widespread pain were examined and filled in a base questionnaire (BQ). Of them, 42 fulfilled the Yunus criteria for pFM. Twenty-six years later, addresses of 38 pa...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-017-3967-0

    authors: Isomeri R,Mikkelsson M,Partinen M,Kauppi MJ

    更新日期:2018-05-01 00:00:00

  • Concomitant new diagnosis of systemic lupus erythematosus and COVID-19 with possible antiphospholipid syndrome. Just a coincidence? A case report and review of intertwining pathophysiology.

    abstract::In the midst of the COVID-19 pandemic, further understanding of its complications points towards dysregulated immune response as a major component. Systemic lupus erythematosus (SLE) is also a disease of immune dysregulation leading to multisystem compromise. We present a case of new-onset SLE concomitantly with COVID...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/s10067-020-05310-1

    authors: Mantovani Cardoso E,Hundal J,Feterman D,Magaldi J

    更新日期:2020-09-01 00:00:00

  • Anti-cyclic citrullinated peptide antibodies in scleroderma patients.

    abstract::Anti-CCP (cyclic citrullinated peptide) is considered the most useful laboratory tool in the diagnosis of rheumatoid arthritis (RA). Some authors have also found this autoantibody in patients with scleroderma (SSc). The study aimed to investigate the prevalence of anti-CCP antibodies in SSc patients from Southern Braz...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-011-1930-z

    authors: Polimeni M,Feniman D,Skare TS,Nisihara RM

    更新日期:2012-05-01 00:00:00

  • Subcutaneous sarcoidosis: report of two cases and review of the literature.

    abstract::Sarcoidosis is a multisystemic disease with cutaneous lesions present in about one fourth of patients. Cutaneous lesions may be specific or nonspecific based on the presence or the absence of sarcoidal granulomas. Subcutaneos sarcoidosis is the less frequent of the specific cutaneous lesions of sarcoidosis. We report ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/s10067-011-1731-4

    authors: Dalle Vedove C,Colato C,Girolomoni G

    更新日期:2011-08-01 00:00:00