Abstract:
OBJECTIVE:Adult-onset Still's disease (AOSD) is an autoinflammatory disorder leading to multiorgan involvements. We sought to investigate mood status and the health-related quality of life (HRQoL) in these patients. METHODS:In this study, 82 AOSD patients and 82 age- and sex-matched healthy controls were included. Demographic and clinical data of recruited patients were collected. The Hospital Anxiety and Depression Scale (HADS) and Medical Outcomes Survey Short Form-36 (SF-36) were used to evaluate the mood status and quality of life, respectively. Spearman correlation and multivariable linear regression analyses were used to assess the disease-related risk factors associated with anxiety and depression. RESULTS:Forty-four active and thirty-eight relieved patients were enrolled. We found that scores of both HADS anxiety (HADS-A) and depression (HADS-D) subscales in active AOSD were significantly higher than inactive patients, which were significantly higher than controls. Moreover, the HADS-A was positively correlated to the patient's global assessment (PGA), pain, and dosage of prednisone, and the HADS-D was positively correlated to systemic score, PGA, and pain. Female, high dosage of corticosteroids, and PGA more than 50 had a significant association with HADS-A score, while the sore throat and PGA more than 50 had a significant association with HADS-D score. Furthermore, AOSD patients' anxiety and depression had a negative impact on HRQoL. CONCLUSION:Active AOSD patients tended to be anxious and depressed, suffering from poorer HRQoL compared to patients in remission. Therefore, the evaluation of mental health and HRQoL should be included in AOSD patients' long-term management. Key Points • Adult-onset Still's disease (AOSD) is a systemic inflammatory disorder leading to multiorgan involvement. This study was so far the first published research focuses on AOSD patients' mental involvement and health-related quality of life (HRQoL). • Active AOSD patients were more tended to be anxious and depressive and suffered from poorer HRQoL compared to inactive patients. • Patients' anxiety and depression were associated with impaired HRQoL.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Chi H,Jin H,Wang Z,Feng T,Zeng T,Shi H,Wu X,Wan L,Teng J,Sun Y,Liu H,Cheng X,Ye J,Hu Q,Zhou Z,Gu J,Jia J,Liu T,Qiao X,Yang C,Su Ydoi
10.1007/s10067-020-05094-4subject
Has Abstractpub_date
2020-12-01 00:00:00pages
3723-3732issue
12eissn
0770-3198issn
1434-9949pii
10.1007/s10067-020-05094-4journal_volume
39pub_type
杂志文章abstract::To estimate the mortality and describe the causes of death in a large multicenter cohort of hospitalized patients with SLE in China. This was a retrospective study of a nationwide SLE cohort (10 centers, 29,510 hospitalized patients) from 2005 to 2014 in China. Standardized mortality ratios (SMRs) were calculated for ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,多中心研究
doi:10.1007/s10067-018-4259-z
更新日期:2019-01-01 00:00:00
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journal_title:Clinical rheumatology
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doi:10.1007/s10067-002-0639-4
更新日期:2003-02-01 00:00:00
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journal_title:Clinical rheumatology
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更新日期:1986-01-01 00:00:00
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pub_type: 杂志文章
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF01452269
更新日期:1998-01-01 00:00:00
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journal_title:Clinical rheumatology
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journal_title:Clinical rheumatology
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pub_type: 杂志文章,评审
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journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/BF02229861
更新日期:1994-03-01 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2014-01-01 00:00:00
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