A case report of tumor necrosis factor-alpha antibody-induced thrombocytopenia associated with emerging IgM anticardiolipin antibody in patients with scleroderma overlap/rheumatoid arthritis.

Abstract:

:It is commonly believed that infliximab-induced anticardiolipin antibody belongs to the IgM subclass but not the IgG subclass and that the IgM subclass could not produce clinical symptoms. However, we had a patient with scleroderma overlap/rheumatoid arthritis who developed thrombocytopenia associated with the appearance of IgM anticardiolipin antibody after treatment with infliximab. This is a report of a rare case that should make us aware of the possibility of the development of thrombocytopenia with the appearance of IgM anticardiolipin antibody induced by infliximab.

journal_name

Clin Rheumatol

journal_title

Clinical rheumatology

authors

Hamaguchi M,Kawahito Y,Ishino H,Yoshida M,Yoshikawa T

doi

10.1007/s10067-006-0229-y

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

988-90

issue

6

eissn

0770-3198

issn

1434-9949

journal_volume

26

pub_type

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