当前位置： SCI文献检索 > CLINICAL RHEUMATOLOGY期刊下所有文献 > A cross-sectional study of autoantibody profiles in the Waikato systemic sclerosis cohort, New Zealand.

A cross-sectional study of autoantibody profiles in the Waikato systemic sclerosis cohort, New Zealand.

Abstract：

:The autoantibody profiles in New Zealand systemic sclerosis patients have not previously been reported. The aim of this study was to evaluate the autoantibody profiles of patients in the Waikato Hospital Systemic Sclerosis Clinic cohort. The EUROLINE (IgG) Systemic Sclerosis panel test kit (which tests for Scl-70, CENP-A, CENP-B, RP11, RP155, Fib, NOR90, Th/To, PM100, PM75, Ku, PDGFR and Ro-52) was selected for the purpose of this study. All patients attending the Waikato Hospital Systemic Sclerosis clinic were invited to participate. These patients were categorised by systemic sclerosis subtypes [1]. Results were compared with previously published data, including the EUSTAR database. Sixty patients (56 female) were recruited, with a median age of 61 years (range 29-81 years). Forty-one had limited cutaneous systemic sclerosis (lcSSc). Of these lcSSc patients, 31 (75.6%) were positive for CENP-A and CENP-B (anti-centromere) antibodies, 12 (29.3%) for Ro-52 antibodies, 5 (12.2%) for RP11 and RP155, 4 (9.8%) for Scl-70 and 1 (2.4%) each for anti-Fib and Th/To antibodies. Fifteen patients had diffuse cutaneous systemic sclerosis (dcSSc), of which 7 patients (47.6%) were positive for RP11 and RP155, 4 (26.7%) for Scl-70. Three dcSSc patients did not have either of these two major antibodies, but of these 15 dcSSc patients, 4 patients (26.7%) were positive also for Ro-52, 2 (13.3%) for anti-Ku, and 1 (6.7%) each for anti-Fib and NOR90. Four patients had overlap syndrome (OLS), 1 had CENP-A and CENP-B antibodies, 1 had Ro-52 autoantibodies 1 had anti-Ku antibodies. Three patients had no autoantibodies. This is the first study to look at the autoantibody profile of SSc patients in New Zealand. A higher prevalence of antibodies against centromere and RNA polymerase III was demonstrated in our group compared with the EUSTAR database suggesting that antibody prevalence may vary geographically.

journal_name

Clin Rheumatol

journal_title

Clinical rheumatology

authors

Chang WS,Schollum J,White DH,Solanki KK

doi

10.1007/s10067-015-2981-3

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

1921-7

issue

11

eissn

0770-3198

issn

1434-9949

pii

10.1007/s10067-015-2981-3

journal_volume

34

pub_type

杂志文章

相关文献

CLINICAL RHEUMATOLOGY文献大全
  • Systemic lupus erythematosus presenting as catatonic schizophrenia.

    abstract：:A patient fulfilling the diagnostic criteria for systemic lupus erythematosus and presenting with catatonic schizophrenia is described. Psychiatric features of the disease and their management are discussed. ...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/BF02031619

    authors： Tishler M,Abramov AL

    更新日期：1985-09-01 00:00:00

  • Silica-related rheumatoid arthritis without lung involvement.

    abstract：:We report a young male with recent onset of rheumatoid arthritis (RA) in whom the remarkable severity of the disease led to additional investigations. The only significant finding was mediastinal lymphadenopathy, without lung involvement. Biopsy of the mediastinal lymph node revealed pathological findings typical of s...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/s10067-002-0639-4

    authors： Markovits D,Schapira D,Wiener A,Nahir AM

    更新日期：2003-02-01 00:00:00

  • Venous vessel wall thickness in lower extremity is increased in male patients with Behcet's disease.

    abstract：:Vascular involvement, especially in young males, is seen in up to 40% of the patients with Behcet's disease (BD) and is a major cause of mortality and morbidity. In this study, we investigated vessel wall thickness (VWT) and dilatation in lower extremity veins with Doppler ultrasound (US) in male BD patients. Sixty-on...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/s10067-019-04470-z

    authors： Alibaz-Oner F,Ergelen R,Mutis A,Erturk Z,Asadov R,Mumcu G,Ergun T,Direskeneli H

    更新日期：2019-05-01 00:00:00

  • Screening for the presence of FMR1 premutation alleles in a Spanish population with fibromyalgia.

    abstract：:Fragile X mental retardation 1 (FMR1) premutation carriers, who are at risk of having children with fragile X Syndrome, were initially considered as clinically unaffected. However, recent clinical and molecular studies have shifted this point of view. The incidence of premutation in the general population is substanti...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/s10067-012-2052-y

    authors： Martorell L,Tondo M,Garcia-Fructuoso F,Naudo M,Alegre C,Gamez J,Genovés J,Poo P

    更新日期：2012-11-01 00:00:00

  • Decreased interleukin-20 level in patients with systemic sclerosis: are they related with angiogenesis?

    abstract：:In this study, we aimed to evaluate the relation between angiogenesis indicators and T helper 17 cytokine group in patients with systemic sclerosis (SSc) which is a disease characterized by impaired angiogenesis and autoimmune response. In our study, patients with SSc are compared with patients with primary Raynaud's ...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/s10067-013-2317-0

    authors： Aydoğdu E,Pamuk ÖN,Dönmez S,Pamuk GE

    更新日期：2013-11-01 00:00:00

  • Immunization of HLA-B27 transgenic and non transgenic mice with Salmonella typhimurium results predominantly in the generation of proliferative T cell responses.

    abstract：:Reactive arthritis (ReA) due to Gram-negative intestinal bacteria or Chlamydia, is associated by an unknown mechanism with HLA-B27. Like other MHC class I molecules, HLA-B27 presents antigenic peptides derived from intracellular proteins to CD8+ cytotoxic T cells (CTL). In humans however, CTL specific for ReA associat...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/BF03342653

    authors： Ringrose JH,Yard BA,Verjans GM,Boog CJ

    更新日期：1996-01-01 00:00:00

  • Efficacy and safety results from a randomized double-blind study comparing proposed biosimilar ABP 798 with rituximab reference product in subjects with moderate-to-severe rheumatoid arthritis.

    abstract：BACKGROUND/OBJECTIVES:ABP 798 is a proposed biosimilar to the originator biologic rituximab, an anti-CD20 monoclonal antibody. This comparative clinical study evaluated the pharmacokinetics (PK), safety, and efficacy of ABP 798 versus rituximab reference product (RP) in patients with moderate-to-severe rheumatoid arthr...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/s10067-020-05305-y

    authors： Burmester G,Drescher E,Hrycaj P,Chien D,Pan Z,Cohen S

    更新日期：2020-11-01 00:00:00

  • Expression of CD22 on peripheral B cells in patients with rheumatoid arthritis: relation to CD5-positive B cells.

    abstract：:B cells in patients with rheumatoid arthritis (RA) are hyperactivated. Although B cell receptor signal transduction may be affected by various response regulators, CD22 plays an important role as a response regulator of B cells. Therefore, we investigated and examined CD22 expression on peripheral blood B cells of pat...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/s10067-007-0665-3

    authors： Nakiri Y,Minowa K,Suzuki J,Mitsuo A,Amano H,Morimoto S,Tokano Y,Takasaki Y

    更新日期：2007-10-01 00:00:00

  • Comparison of effectiveness and safety of infliximab, etanercept, and adalimumab in psoriatic arthritis patients who experienced an inadequate response to previous disease-modifying antirheumatic drugs.

    abstract：:The aim of this study is to compare effectiveness and safety of Infliximab (INF), Etanercept (ETN), and Adalimumab (ADA) in patients with psoriatic arthritis (PsA) with inadequate response to a previous disease-modifying antirheumatic drug (DMARD). One hundred consecutive PsA patients with inadequate response to a pre...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s10067-009-1340-7

    authors： Atteno M,Peluso R,Costa L,Padula S,Iervolino S,Caso F,Sanduzzi A,Lubrano E,Del Puente A,Scarpa R

    更新日期：2010-04-01 00:00:00

  • Efficacy of transforaminal versus interspinous corticosteroid injectionin discal radiculalgia - a prospective, randomised, double-blind study.

    abstract：:A prospective, randomised, double-blind study was carried out to compare the respective efficacies of transforaminal and interspinous epidural corticosteroid injections in discal radiculalgia. Thirty-one patients (18 females, 13 males) with discal radicular pain of less than 3 months' duration were consecutively rando...

    journal_title：Clinical rheumatology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s10067-003-0736-z

    authors： Thomas E,Cyteval C,Abiad L,Picot MC,Taourel P,Blotman F

    更新日期：2003-10-01 00:00:00

  • The comparison of visfatin levels of gingival crevicular fluid in systemic lupus erythematosus and chronic periodontitis patients with healthy subjects.

    abstract：BACKGROUND:Visfatin is an adipokine and has a crucial role in pro-inflammatory response. The aim of this study was investigating the visfatin levels of gingival crevicular fluid (GCF) in patients with systemic lupus erythematosus (SLE) and chronic periodontitis and healthy subjects. MATERIALS AND METHODS:Sixty non-obe...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/s10067-019-04708-w

    authors： Rezaei M,Bayani M,Tasorian B,Mahdian S

    更新日期：2019-11-01 00:00:00

  • A multicenter study of patients with adult-onset Still's disease compared with systemic juvenile idiopathic arthritis.

    abstract：:Adult-onset Still's disease (AOSD) has often been regarded as the adult spectrum of systemic juvenile idiopathic arthritis (sJIA). The present study aims to compare the clinical and laboratory features, the disease course and the response to treatment in patients having AOSD with those having sJIA. Retrospective revie...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s10067-005-0138-5

    authors： Pay S,Türkçapar N,Kalyoncu M,Simşek I,Beyan E,Ertenli I,Oztürk MA,Düzgün N,Erdem H,Ozbalkan Z,Kiraz S,Kinikli G,Besbas N,Dinç A,Ateş A,Olmez U,Calgüneri M,Aydintuğ OT,Bakkaloğlu A,Turan M,Turgay M,Karaaslan Y,

    更新日期：2006-09-01 00:00:00

  • Early diagnosis of psoriatic arthritis among psoriasis patients: clinical experience sharing.

    abstract：BACKGROUND:The early detection of psoriatic arthritis (PSA) poses a challenge to rheumatologists, even when their diagnosis is aided by sonography. In order to facilitate early detection of PSA among patients with psoriasis (PSO), we retrospectively analyzed of the relationships between serological markers and comorbid...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/s10067-020-05132-1

    authors： Su YJ

    更新日期：2020-12-01 00:00:00

  • Colonic transit disorders in systemic sclerosis.

    abstract：:Systemic sclerosis (SS) alters smooth muscle function throughout the gastrointestinal tract, the oesophagus being the segment most often involved. Involvement of the colon, though less common, may lead to life-threatening complications. We studied 23 unselected patients with SS and 20 age-matched healthy controls usin...

    journal_title：Clinical rheumatology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s100670170038

    authors： Wang SJ,Lan JL,Chen DY,Chen YH,Hsieh TY,Lin WY

    更新日期：2001-01-01 00:00:00

  • Adrenal axis functions in patients with familial Mediterranean fever.

    abstract：OBJECTIVE:Familial Mediterranean fever (FMF) is a hereditary disease characterized by recurrent attacks of fever with peritonitis, arthritis, pleuritis or erysipelas-like rash. It is unclear what effects of FMF itself on endocrine system and hormones are. None of the FMF patients without amyloidosis have been reported ...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/s10067-005-0083-3

    authors： Sav T,Ozbakir O,Kelestimur F,Gursoy S,Baskol M,Kula M,Dundar M

    更新日期：2006-07-01 00:00:00

  • Role of cytolytic impairment of natural killer and natural killer T-cell populations in rheumatoid arthritis.

    abstract：:Innate immunity has been widely accepted as one of the major cause for the alteration of immune system and progression of autoimmune diseases. Natural killer (NK) cells and natural killer T (NKT) cells have not been explored in clinical studies for their cytolytic components in association with rheumatoid arthritis (R...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/s10067-014-2641-z

    authors： Aggarwal A,Sharma A,Bhatnagar A

    更新日期：2014-08-01 00:00:00

  • Type I osteogenesis imperfecta: diagnostic difficulties.

    abstract：:A 65-year-old woman presented with vertebral fractures of the lumbar spine and a history of pathological fractures following minor trauma, which had occurred before the onset of menopause. Her past medical history was significant for intermittent low back pain since childhood, which was attributed to thoracolumbar sco...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/s100670050052

    authors： Bischoff H,Freitag P,Jundt G,Steinmann B,Tyndall A,Theiler R

    更新日期：1999-01-01 00:00:00

  • From scleredema to AL amyloidosis: disease progression or coincidence? Review of the literature.

    abstract：:Scleredema (also called scleredema of Buschke) is a fibromucinous connective tissue disorder of unknown cause that belongs to a group of scleroderma-like disorders. We report the case of a 64-year-old lady with long-standing scleredema, associated with a paraprotein, and progressing to multiple myeloma and AL amyloido...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章,评审

    doi：10.1007/s10067-004-1076-3

    authors： Dziadzio M,Anastassiades CP,Hawkins PN,Potter M,Gabrielli A,Brough GM,Black CM,Denton CP

    更新日期：2006-02-01 00:00:00

  • Rheumatoid factor false positivity in patients with ANCA-associated vasculitis not having medical conditions producing rheumatoid factor.

    abstract：:We investigated the rate of rheumatoid factor (RF) false positivity at diagnosis and its influence on clinical and prognostic features and rheumatoid arthritis (RA) development during the follow-up in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) patients without RA or other medical conditions...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/s10067-017-3902-4

    authors： Moon JS,Lee DD,Park YB,Lee SW

    更新日期：2018-10-01 00:00:00

  • Circulating levels of interleukin-6, vascular endothelial growth factor, YKL-40, matrix metalloproteinase-3, and total aggrecan in spondyloarthritis patients during 3 years of treatment with TNFα inhibitors.

    abstract：:The objectives of the study were to investigate short and long-term changes and relations to treatment response of plasma interleukin-6 (IL-6), vascular endothelial growth factor (VEGF), YKL-40, matrix metalloproteinase-3 (MMP-3), and total aggrecan in patients with spondyloarthritis (SpA) treated with tumor necrosis ...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/s10067-010-1528-x

    authors： Pedersen SJ,Hetland ML,Sørensen IJ,Ostergaard M,Nielsen HJ,Johansen JS

    更新日期：2010-11-01 00:00:00

  • High frequency of hysterectomies and appendectomies in fibromyalgia compared with rheumatoid arthritis: a pilot study.

    abstract：:We investigated, in retrospect, if there were differences in the frequency and types of abdominal surgery between newly diagnosed female fibromyalgia (n = 80) and rheumatoid arthritis (n = 47) patients performed before the formal diagnosis. There was no difference in the total number of abdominal operations between bo...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/s100670050042

    authors： ter Borg EJ,Gerards-Rociu E,Haanen HC,Westers P

    更新日期：1999-01-01 00:00:00

  • Watch out for 'pins and needles' in hands--it may be a case of gout.

    abstract：:We encountered only three patients of carpal tunnel syndrome (CTS) due to tophaceous gout during 25 years of practice in a 'hand clinic' situated in a large metropolis in West India. In two patients, the CTS was bilateral, a rare occurrence in gout. There was an unwarranted delay (up to 9 years) in the diagnosis of bo...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/s10067-007-0672-4

    authors： Patil VS,Chopra A

    更新日期：2007-12-01 00:00:00

  • Polymorphism of the LMP2 gene and disease phenotype in ankylosing spondylitis: no association with disease severity.

    abstract：:Although a number of reports have now described an association between polymorphism of the LMP2 gene and disease phenotype in HLA-B27 positive individuals with ankylosing spondylitis (AS), some describe associations with acute anterior uveitis, others with juvenile onset disease, and one report provides no association...

    journal_title：Clinical rheumatology

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF02238938

    authors： Maksymowych WP,Adlam N,Lind D,Russell AS

    更新日期：1997-09-01 00:00:00

  • Two cases demonstrating thalidomide's efficacy in refractory lupus nephritis.

    abstract：:Renal involvement in systemic lupus erythematosus (SLE) is common and has been associated with an increased risk of mortality [1]. Early diagnosis is imperative to control proteinuria and prevent the progression to end-stage renal disease. Standard induction therapies include cyclophosphamide (CYC) and mycophenolate m...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章,评审

    doi：10.1007/s10067-016-3511-7

    authors： Raturi R,Patel AA,Carter JD

    更新日期：2017-03-01 00:00:00

  • Fear of movement and avoidance behaviour toward physical activity in chronic-fatigue syndrome and fibromyalgia: state of the art and implications for clinical practice.

    abstract：:Severe exacerbation of symptoms following physical activity is characteristic for chronic-fatigue syndrome (CFS) and fibromyalgia (FM). These exacerbations make it understandable for people with CFS and FM to develop fear of performing body movement or physical activity and consequently avoidance behaviour toward phys...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章,评审

    doi：10.1007/s10067-013-2277-4

    authors： Nijs J,Roussel N,Van Oosterwijck J,De Kooning M,Ickmans K,Struyf F,Meeus M,Lundberg M

    更新日期：2013-08-01 00:00:00

  • Pigmented villonodular synovitis of the hip. A case report and review of the literature.

    abstract：:A 73-year-old patient, whose hip was completely destroyed by pigmented villonodular synovitis, was successfully treated by a total prosthetic replacement of this articulation. The etiopathogenesis of the illness is uncertain. Its' localization in the hip is, fortunately, a rare occurrence. It can be responsible for fr...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章,评审

    doi：10.1007/BF02207662

    authors： Descamps F,Yasik E,Hardy D,Lafontaine M,Delince P

    更新日期：1991-06-01 00:00:00

  • The effect of colchicine and disease severity on physical growth in children with familial Mediterranean fever.

    abstract：:This study aimed to investigate the effects of colchicine on growth parameters in familial Mediterranean fever (FMF) patients. Fifty-one (29 girls, 22 boys) FMF patients were enrolled in the study. All of the patients were in the prepubertal stage and had not received colchicine treatment before the study. Anthropomet...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/s10067-015-3077-9

    authors： Yoldaş TÇ,Çakar N,Başaran Ö,Acar B,Uncu N,Çaycı FŞ

    更新日期：2016-06-01 00:00:00

  • Investigations concerning vitamin A transport in rheumatic diseases.

    abstract：:The investigation concerned changes in vitamin A derivatives (retinol and retinyl) content in serum of patients suffering from two types of rheumatic diseases--rheumatoid arthritis (RA) and osteoarthrosis. Healthy women of similar age served as control. It was found that the retinol content of the serum in the group s...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/BF02042773

    authors： Mezes M,Bartosiewicz B

    更新日期：1982-09-01 00:00:00

  • Higher activation of the interferon-gamma signaling pathway in systemic lupus erythematosus patients with a high type I IFN score: relation to disease activity.

    abstract：:Increased IFN-γ levels have been associated with systemic lupus erythematosus (SLE). However, the relationships among IFN-γ, type I interferons (IFNs) and clinical features have not been extensively studied. Peripheral blood samples from 44 SLE patients and 36 healthy donors (HDs) were collected. Quantitative real-tim...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/s10067-018-4138-7

    authors： Liu M,Liu J,Hao S,Wu P,Zhang X,Xiao Y,Jiang G,Huang X

    更新日期：2018-10-01 00:00:00

  • A case of anti-Jo1 myositis with pleural effusions and pericardial tamponade developing after exposure to a fermented Kombucha beverage.

    abstract：:The pathogenesis of the idiopathic inflammatory myopathies has been postulated to be an environmental trigger causing the expression of the disease in a genetically predisposed patient. We report a case of anti-Jo1 antibody-positive myositis which was associated with pleural effusions, pericardial effusion with tampon...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/s10067-004-0890-y

    authors： Derk CT,Sandorfi N,Curtis MT

    更新日期：2004-08-01 00:00:00