Abstract：
:Renal involvement in systemic lupus erythematosus (SLE) is common and has been associated with an increased risk of mortality [1]. Early diagnosis is imperative to control proteinuria and prevent the progression to end-stage renal disease. Standard induction therapies include cyclophosphamide (CYC) and mycophenolate mofetil (MMF); however, it has been estimated that approximately 30% of patients are refractory to these standard treatments after 1 year [2]. We present two cases of patients diagnosed with lupus nephritis (LN) who demonstrated persistent proteinuria while on standard treatments that markedly improved after addition of thalidomide (THD). A literature review was performed indicating that THD use with prednisolone (PL) was more efficacious than MMF with PL in resolving lupus nephritis in a mouse model. Thalidomide, which was well tolerated, was associated with a reduction in the protein-to-creatinine ratio with sustained results in both of our patient cases. These cases suggest more clinical data is needed to explore the potential utility of thalidomide in the treatment of LN.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Raturi R,Patel AA,Carter JDdoi
10.1007/s10067-016-3511-7subject
Has Abstractpub_date
2017-03-01 00:00:00pages
725-728issue
3eissn
0770-3198issn
1434-9949pii
10.1007/s10067-016-3511-7journal_volume
36pub_type
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