Abstract:
:Scleredema (also called scleredema of Buschke) is a fibromucinous connective tissue disorder of unknown cause that belongs to a group of scleroderma-like disorders. We report the case of a 64-year-old lady with long-standing scleredema, associated with a paraprotein, and progressing to multiple myeloma and AL amyloidosis. The relationship of scleredema with paraprotein and multiple myeloma is well established, but only two cases of scleredema associated with amyloidosis have been reported to date. We suggest that amyloidosis may be underdiagnosed in patients with scleredema and paraproteinaemia. Features attributed to extracutaneous manifestations of scleredema could represent systemic amyloidosis. We review published reports of scleredema associated with paraprotein and discuss the difficulties in the differential diagnosis of scleroderma-like disorders. We discuss the diagnosis of plasma cell dyscrasias and amyloidosis and their relevance in rheumatology practice.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Dziadzio M,Anastassiades CP,Hawkins PN,Potter M,Gabrielli A,Brough GM,Black CM,Denton CPdoi
10.1007/s10067-004-1076-3subject
Has Abstractpub_date
2006-02-01 00:00:00pages
3-15issue
1eissn
0770-3198issn
1434-9949journal_volume
25pub_type
杂志文章,评审abstract:INTRODUCTION:Silicone breast implants (SBI) may induce systemic autoimmune disease as part of autoimmune syndrome induced by adjuvants (ASIA). This syndrome bears similarities to fibromyalgia and chronic fatigue syndrome (CFS). We sought to determine whether there are any associations between SBI and depression, fibrom...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-019-04447-y
更新日期:2019-05-01 00:00:00
abstract::A white female patient developed overlapping features of systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) with severe pulmonary compromise. She was treated with steroids and azathioprine, which improved her clinical condition and spirometric status. In May 2002 she presented with continuous pain in her ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-004-1048-7
更新日期:2005-08-01 00:00:00
abstract::To determine serum interleukin-33 (IL-33) levels and their associations with clinical parameters in patients with systemic sclerosis (SSc). Serum IL-33 levels were examined by enzyme-linked immunosorbent assay in 69 patients with SSc and 30 healthy individuals. In a retrospective longitudinal study, sera from 14 patie...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-011-1686-5
更新日期:2011-06-01 00:00:00
abstract::A 71-year-old male rheumatoid patient presented with MRSA septic arthritis. The impact of this organism on musculoskeletal practice is discussed. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF01450904
更新日期:1998-01-01 00:00:00
abstract::This study aimed to determine the frequency of rheumatoid factor (RF) and cyclic citrullinated peptide (CCP) antibodies in a cohort of patients with palindromic rheumatism (PR) and to find determinants for progression to rheumatoid arthritis (RA). All new cases of PR (n=90) were included prospectively and followed up ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-014-2569-3
更新日期:2014-06-01 00:00:00
abstract::This paper describes four patients with inflammatory joint diseases treated with methotrexate who developed lymphoma either of unusual type or with bizarre clinical features. The pathogenesis of this unusual condition is discussed and the difficulty in differentiating it from the features of the initial disease is emp...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670170112
更新日期:2001-01-01 00:00:00
abstract::The original version of this article contained error. Table 1 was shown in the wrong version, thus corrected table is shown in this article. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,已发布勘误
doi:10.1007/s10067-019-04480-x
更新日期:2019-06-01 00:00:00
abstract::The objective of the study was to determine clinical factors associated with activity limitation and predictors of a change in activity limitation after 1 year in people with gout. Two hundred ninety-five participants with gout (disease duration < 10 years) attended a baseline assessment which included medical and dis...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4110-6
更新日期:2018-08-01 00:00:00
abstract::In this study, we aimed to evaluate the relation between angiogenesis indicators and T helper 17 cytokine group in patients with systemic sclerosis (SSc) which is a disease characterized by impaired angiogenesis and autoimmune response. In our study, patients with SSc are compared with patients with primary Raynaud's ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-013-2317-0
更新日期:2013-11-01 00:00:00
abstract::Rheumatoid arthritis (RA) is a progressive inflammatory disease. Although the etiology and pathogenesis of RA are not known well, genetic and environmental factors are proposed to initiate an autoimmune process. We aimed to investigate mRNA expression levels of Toll-like receptor-2 (TLR-2), TLR-4, and interleukin-6 (I...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-016-3282-1
更新日期:2016-11-01 00:00:00
abstract::Two cases of late hypophosphatemic osteomalacia are described: a male aged 30 who had the disease since he was 22 and a woman of 23 who had the disease since she was 14. Both presented with myopathy and bone pain, and showed hypophosphatemia, hyperglycinuria, reduced tubular phosphate reabsorption (TPR), increased hyd...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02031617
更新日期:1985-09-01 00:00:00
abstract::Antibodies to beta(2)-glycoprotein I (anti-beta(2)-GPI) have been reported to have stronger association with clinical antiphospholipid syndrome (APS) than anticardiolipin antibodies (aCL) and lupus anticoagulant (LAC). We investigated the sensitivity and specificity of ELISA for anti-beta(2)-GPI in Thai systemic lupus...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-007-0566-5
更新日期:2007-10-01 00:00:00
abstract::The autoantibody profiles in New Zealand systemic sclerosis patients have not previously been reported. The aim of this study was to evaluate the autoantibody profiles of patients in the Waikato Hospital Systemic Sclerosis Clinic cohort. The EUROLINE (IgG) Systemic Sclerosis panel test kit (which tests for Scl-70, CEN...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-015-2981-3
更新日期:2015-11-01 00:00:00
abstract::Expectancies play a major role for the treatment outcome of a broad variety of immune-mediated conditions and may strengthen or mimic the effects of regular long-term therapies. This study adds to a recently published study of Kox et al. (PNAS 111:7379-7384, 2014) on the ability to voluntarily influence the physiologi...
journal_title:Clinical rheumatology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10067-015-3009-8
更新日期:2016-04-01 00:00:00
abstract::Acute gouty arthritis (AGA) is an auto-inflammatory disease characterized by resolving spontaneously, which suggests that negative feedback loops control inflammatory and immunological responses to monosodium urate (MSU) crystals. By now, the molecular mechanism for spontaneous resolution of acute GA remains unclear; ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-015-3109-5
更新日期:2016-09-01 00:00:00
abstract::Survival and outcomes have improved considerably among patients with juvenile dermatomyositis (JDM) in the west. However, mortality continues to be high in the developing world. There is paucity of literature on this aspect of JDM from developing countries. We reviewed case files of all patients with JDM registered in...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-014-2747-3
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVE:Anti-cyclic citrullinated peptide 2 antibodies (anti-CCP2) and rheumatoid factor (RF) in rheumatoid arthritis (RA) has been extensively assessed in industrialized countries. We investigated the diagnostic and prognostic impact of anti-CCP2 and RF isotypes in a Sudanese cross-sectional RA cohort. METHODS:Cons...
journal_title:Clinical rheumatology
pub_type: 杂志文章,多中心研究
doi:10.1007/s10067-019-04431-6
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVE:The objectives of our study were to compare the efficacy of febuxostat with allopurinol in Thai subjects with gout, as well as to determine the predictive factors of responsiveness to urate-lowering agents and to evaluate the safety of febuxostat in a real-world setting. METHODS:The study was a retrospective...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05262-6
更新日期:2021-01-01 00:00:00
abstract::The authors wish to acknowledge that whilst this study and that published in Hammad et al [1] explore different areas - blood cell ratios and serum endocan, respectively - the reader may identify some similarities between the papers owing to the same patient cohort being analysed in both studies. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,已发布勘误
doi:10.1007/s10067-019-04583-5
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVES:This study was conducted to assess the safety and efficacy of intra-articular injection of etanercept and compare it with corticosteroid injection in rheumatoid arthritis (RA) patients. METHODS:Fifty patients with RA who suffered from activity in one joint were randomized into two groups, received an intra-...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05235-9
更新日期:2021-02-01 00:00:00
abstract::A 43-year-old man suffered from migrating then additive arthralgias associated with macroscopic and microscopic cutaneous lesions compatible at first sight with reticular erythematous mucinosis. After nine months, the cutaneous picture evolved into a papular mucinosis. The patient developed "multiple frozen joints" wi...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02032364
更新日期:1986-06-01 00:00:00
abstract::The objectives of this study are to investigate the prevalence of PAD4 and anti-PAD4 antibodies (Abs) in autoimmune diseases and to clarify their association with anticitrullinated protein antibodies (ACPAs) and shared epitope (SE) in patients with rheumatoid arthritis (RA). Levels of human PAD4 and anti-PAD4 Abs in s...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-015-3082-z
更新日期:2016-05-01 00:00:00
abstract::Microwave thermography is the technique of measuring natural thermal radiation from body tissues of clinical interest. It is safe, requires no control of environmental conditions and exposes the patient to no ionising radiation. In this study, we found that microwave thermography of the knee joints showed weak correla...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02242999
更新日期:1994-12-01 00:00:00
abstract::Biological agents, particularly anti-Tumour Necrosis Factor (TNF)-α agents, have emerged as an effective treatment in patients with chronic inflammatory diseases. An association between anti-TNF-α antibodies and reactivation of latent tuberculosis infection (LTBI) has been established. Appropriate screening for TB inf...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-012-1938-z
更新日期:2012-05-01 00:00:00
abstract::To explore whether femoral cartilage thickness is related (and changes) with muscle strength in subjects with knee osteoarthritis (OA). Forty patients (27 F, 13 M) with knee OA-who were under quadriceps muscle strengthening program-were enrolled in the study. Isokinetic/isometric knee muscle strength measurements (at ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-016-3271-4
更新日期:2016-08-01 00:00:00
abstract::Familial Mediterranean fever (FMF) is the most common inherited periodic fever syndrome characterized by recurrent episodes of serositis. Recently, a few studies have suggested that FMF is related to increased risk of atherosclerosis. Mean platelet volume (MPV) is a marker of platelet activation. Larger platelets are ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-009-1148-5
更新日期:2009-08-01 00:00:00
abstract::Dego's disease is an uncommon thrombo-occlusive vasculopathy that presented with skin rash and thrombotic complications affecting internal organs that may simulate rheumatic diseases and may be brought to the attention of rheumatologists. We present here a case of a middle-aged woman who presented with acute bowel inf...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-009-1164-5
更新日期:2009-07-01 00:00:00
abstract::Very recently, several studies have convincingly demonstrated the role of infection in the development of the antiphospholipid syndrome. Cross antibody-mediated reactivity due to molecular mimicry between endothelial glycoproteins and microbial products was considered as an important pathogenic mechanism. However, ano...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-006-0352-9
更新日期:2007-03-01 00:00:00
abstract::Melorheostosis is a very rare bone disease of unknown etiology characterised by linear hyperostosis and associated with fibrosis of soft tissues and the skin. This uncommon sclerosing bone dysplasia was first described by Leri and Joanny in 1922, and since then, until 1993, approximately 300 cases were reported in the...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF01451298
更新日期:1998-01-01 00:00:00
abstract::The objective of the current work is to report our preliminary experience with the mizoribine (MZR) intermittent pulse protocol for induction therapy for newly diagnosed pediatric-onset systemic lupus erythematosus (SLE). Five consecutive patients who were newly diagnosed as having SLE with biopsy-proven lupus nephrit...
journal_title:Clinical rheumatology
pub_type: 临床试验,杂志文章
doi:10.1007/s10067-007-0635-9
更新日期:2008-01-01 00:00:00