Abstract:
:Biological agents, particularly anti-Tumour Necrosis Factor (TNF)-α agents, have emerged as an effective treatment in patients with chronic inflammatory diseases. An association between anti-TNF-α antibodies and reactivation of latent tuberculosis infection (LTBI) has been established. Appropriate screening for TB infection has become mandatory before starting a treatment based on TNF-α inhibition. The objective was to determine the usefulness of IFN-γ release assays in diagnosing LTBI in patients with inflammatory rheumatic diseases scheduled for anti-TNF-α treatment. The study included 53 individuals with inflammatory rheumatism. All patients had a TST, a chest radiograph, QuantiFERON Gold In-Tube (QFN-G-IT) and T-SPOT.TB. To investigate the influence of non-tuberculous mycobacteria (NTM) infections on non-BCG-vaccinated patients, with a positive TST result and both negative IFN-γ assays, we performed an ex vivo ELISPOT, stimulating the cells separately with NTM sensitins. TST was positive in 7 cases, T-SPOT.TB in 11 and QFN-G-IT in 9 cases. Agreement between TST and T-SPOT.TB and QFN-G-IT was 77.35% (κ = 0.33 and κ = 0.40, respectively), and between both in vitro tests, it was 83.01% (κ = 0.57). Of the three patients with positive TST and negative T-SPOT.TB and QFN-G-IT, one positive ELISPOT result was obtained after stimulation with NTM sensitins. Positive TST, T-SPOT.TB and QFN-G-IT results were not affected by the immunosuppressive therapies. IFN-γ release assays are useful methods for avoiding TST false-positive results, but in those patients with a high risk of developing active TB and in the absence of predictive value studies in this specific kind of population for knowing how safe is the use of IGRAs alone, the combined use of TST and IFN-γ tests should be recommended in order to increase the overall number of LTBI diagnoses.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Mínguez S,Latorre I,Mateo L,Lacoma A,Diaz J,Olivé A,Domínguez Jdoi
10.1007/s10067-012-1938-zsubject
Has Abstractpub_date
2012-05-01 00:00:00pages
785-94issue
5eissn
0770-3198issn
1434-9949journal_volume
31pub_type
杂志文章abstract::We report a patient with idiopathic portal hypertension (IPH) associated with systemic sclerosis (SSc) and Sjögren's syndrome. A 72-year-old Japanese woman was admitted to our hospital because of Raynaud's phenomenon, sclerodactyly, and dyspnea. The patient had splenomegaly, esophageal varices in the absence of extrah...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-005-1084-y
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abstract:OBJECTIVES:The aim of this study is to analyze the prevalence of myositis-specific autoantibodies (MSAs) and to elucidate their associations with clinical features in Chinese patients with polymyositis (PM) and dermatomyositis (DM). METHODS:Twelve subsets of MSAs including anti-Mi-2, anti-TIF1-γ, anti-MDA5, anti-NXP2,...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-019-04503-7
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abstract::Behçet's disease (BD) has well-defined pulmonary complications, but cardiopulmonary exercise testing and the strength of the respiratory muscles have not been studied in detail. We aimed to investigate the pulmonary functions tests, inspiratory and expiratory muscle strength and endurance, cardiopulmonary exercise tes...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-006-0508-7
更新日期:2007-09-01 00:00:00
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doi:10.1007/s10067-005-0117-x
更新日期:2006-07-01 00:00:00
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pub_type: 杂志文章,多中心研究
doi:10.1007/s10067-019-04431-6
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pub_type: 杂志文章,评审
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journal_title:Clinical rheumatology
pub_type: 杂志文章,随机对照试验
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journal_title:Clinical rheumatology
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journal_title:Clinical rheumatology
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journal_title:Clinical rheumatology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2008-09-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02207085
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journal_title:Clinical rheumatology
pub_type: 杂志文章
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doi:10.1007/BF02207968
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章,评审
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journal_title:Clinical rheumatology
pub_type: 信件
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更新日期:2005-02-01 00:00:00