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Ten-year progression of coronary artery, carotid artery, and aortic calcification in patients with rheumatoid arthritis.

Abstract：

:Rheumatoid arthritis (RA) is associated with increased vascular calcification, although the rate of progress of calcification is uncertain. The aim of the study was to evaluate the progression of and the predictors for calcification in different vascular beds over 10 years. The 10-year actual coronary calcium score (CS) and 10-year predicted coronary CS, based on the pattern of the general population, were compared. Calcification of the coronary and carotid artery and the aorta was assessed by multi-detector computed tomography. Significant CS progression was determined by the difference between the square root of baseline and square root of follow-up calcium score (i.e., SQRT method). The 10-year predicted coronary CS was based on the mathematical formula derived by the Heinz Nixdorf Recall Study. A total of 49 patients (54 ± 11 years, 90% female) had a follow-up scan after 10.0 ± 0.2 years. The CS in all vascular beds was significantly increased; 55% of the patients had a significant progression of CS in the coronary, 29% in the carotid, and 80% in the aorta. Age and systolic blood pressure (SBP) were independently associated with calcification progression in all vascular beds. Importantly, the absolute increase in 10-year actual coronary CS was significantly higher than that predicted. In patients with RA, calcification in all vascular beds significantly increased over 10 years and was independently associated with age and SBP. Importantly, the absolute increase in 10-year actual coronary CS progression was significantly higher than that predicted.

journal_name

Clin Rheumatol

journal_title

Clinical rheumatology

authors

Liu JH,Ng MY,Cheung T,Chung HY,Chen Y,Zhen Z,Zou Y,Mak KF,Khong PL,Lau CS,Tse HF,Yiu KH

doi

10.1007/s10067-016-3536-y

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

807-816

issue

4

eissn

0770-3198

issn

1434-9949

pii

10.1007/s10067-016-3536-y

journal_volume

36

pub_type

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