Ten-year progression of coronary artery, carotid artery, and aortic calcification in patients with rheumatoid arthritis.


:Rheumatoid arthritis (RA) is associated with increased vascular calcification, although the rate of progress of calcification is uncertain. The aim of the study was to evaluate the progression of and the predictors for calcification in different vascular beds over 10 years. The 10-year actual coronary calcium score (CS) and 10-year predicted coronary CS, based on the pattern of the general population, were compared. Calcification of the coronary and carotid artery and the aorta was assessed by multi-detector computed tomography. Significant CS progression was determined by the difference between the square root of baseline and square root of follow-up calcium score (i.e., SQRT method). The 10-year predicted coronary CS was based on the mathematical formula derived by the Heinz Nixdorf Recall Study. A total of 49 patients (54 ± 11 years, 90% female) had a follow-up scan after 10.0 ± 0.2 years. The CS in all vascular beds was significantly increased; 55% of the patients had a significant progression of CS in the coronary, 29% in the carotid, and 80% in the aorta. Age and systolic blood pressure (SBP) were independently associated with calcification progression in all vascular beds. Importantly, the absolute increase in 10-year actual coronary CS was significantly higher than that predicted. In patients with RA, calcification in all vascular beds significantly increased over 10 years and was independently associated with age and SBP. Importantly, the absolute increase in 10-year actual coronary CS progression was significantly higher than that predicted.


Clin Rheumatol


Clinical rheumatology


Liu JH,Ng MY,Cheung T,Chung HY,Chen Y,Zhen Z,Zou Y,Mak KF,Khong PL,Lau CS,Tse HF,Yiu KH




Has Abstract


2017-04-01 00:00:00














  • Hypercalcaemia in systemic lupus erythematosus.

    abstract::Hypercalcaemia is a common electrolyte abnormality. The vast majority of patients will be shown to have either hyperparathyroidism or malignancy. In less than 10% of patients other, less common causes of hypercalcaemia will be present. Systemic lupus erythematosus is a very rare cause of hypercalcaemia. It may be asso...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Berar-Yanay N,Weiner P,Magadle R

    更新日期:2001-01-01 00:00:00

  • Sjögren's syndrome in patients with ankylosing spondylitis.

    abstract::There are few reports about the coexistence of Sjögren's syndrome (SS) and ankylosing spondylitis (AS). To evaluate the frequency of SS in patients with AS. We studied 70 patients with AS presenting to the university outpatient clinic between January 2002 and November 2003. All the patients were asked about sicca symp...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Kobak S,Kobak AC,Kabasakal Y,Doganavsargil E

    更新日期:2007-02-01 00:00:00

  • Digital vasculitis: a late complication of anti-tumour necrosis factor alpha therapy.

    abstract::Anti-tumour necrosis factor alpha therapy has led to significant advancement in the treatment of rheumatological disease. Rarely, anti-TNFalpha antagonists have been associated with vasculitis, predominantly cutaneous leukocytoclastic vasculitis. We present the first case of angiographically-confirmed digital vasculit...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Mangat P,Whittle S,Cleland L,Limaye V

    更新日期:2008-12-01 00:00:00

  • Hemocytopenia as initial manifestation of systemic lupus erythematosus. Prognostic significance.

    abstract::In 1960 Rabinowitz and Dameshek emphasized the close relationship between idiopathic thrombocytopenic purpura (ITP) and systemic lupus erythematosus (SLE) and suggested that ITP is often a prodrome of SLE. On the basis of tis observation, the present study was designed to investigate the prevalence of SLE in patients ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Lavalle C,Hurtado R,Quezada JJ,Cabral A,Fraga A

    更新日期:1983-09-01 00:00:00

  • Hearing difficulties are common in patients with rheumatoid arthritis.

    abstract::Rheumatoid arthritis (RA) is well known to affect many different organ systems. Previous work suggests that this includes the auditory system and that measures of hearing may be related to indices of RA disease activity. The aims of this study were to determine whether hearing loss in young subjects with rheumatoid ar...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Murdin L,Patel S,Walmsley J,Yeoh LH

    更新日期:2008-05-01 00:00:00

  • The detection of calcium pyrophosphate crystals in sequential synovial fluid examinations of patients with osteoarthritis: once positive, always positive.

    abstract::The aim of this study was to investigate whether calcium pyrophosphate dihydrate (CPPD) crystals are constantly detectable in sequential synovial fluid (SF) examinations of patients with initially CPPD-positive osteoarthritis (OA). For this purpose, we searched our SF database for CPPD-positive patients, who had two o...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Robier C,Neubauer M,Fritz K,Lippitz P,Stettin M,Rainer F

    更新日期:2013-05-01 00:00:00

  • Isolation of anti-nucleosome antibodies from the plasma of lupus nephritis patients.

    abstract::Anti-nucleosome antibodies, which recognise conformational epitopes consisting of histone and DNA in chromatin, have been described in autoimmune diseases. In this study, an attempt was made to isolate anti-nucleosome antibodies from the anti-DNA-depleted plasma IgG of two lupus patients either with or without nephrit...

    journal_title:Clinical rheumatology

    pub_type: 临床试验,杂志文章


    authors: Suenaga R,Mitamura K,Abdou NI

    更新日期:1998-01-01 00:00:00

  • Changes in immune cell frequencies after cyclophosphamide or mycophenolate mofetil treatments in patients with systemic lupus erythematosus.

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    journal_title:Clinical rheumatology

    pub_type: 杂志文章


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    更新日期:2012-06-01 00:00:00

  • Studies on psoriatic osteopathy.

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    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Hein G,Abendroth K,Müller A,Wessel G

    更新日期:1991-03-01 00:00:00

  • The placebo effect and its determinants in fibromyalgia: meta-analysis of randomised controlled trials.

    abstract::The aims of this study were to determine whether placebo treatment in randomised controlled trials (RCTs) is effective for fibromyalgia and to identify possible determinants of the magnitude of any such placebo effect. A systematic literature search was undertaken for RCTs in people with fibromyalgia that included a p...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,meta分析


    authors: Chen X,Zou K,Abdullah N,Whiteside N,Sarmanova A,Doherty M,Zhang W

    更新日期:2017-07-01 00:00:00

  • Clinical characteristics of human brucellosis in patients with various monoarticular involvements.

    abstract::The aim of the study was to determine the main demographic, epidemiological, clinical characteristics, and outcome in patients with various types of brucellar monoarticular involvement. Retrospectively, we analyzed medical histories of 331 patients with brucellar monoarticular involvement who were treated at the infec...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Bosilkovski M,Zezoski M,Siskova D,Miskova S,Kotevska V,Labacevski N

    更新日期:2016-10-01 00:00:00

  • Can procalcitonin be used to distinguish between disease flare and infection in patients with systemic lupus erythematosus: a systematic literature review.

    abstract::Distinction between infection and febrile disease flare in patients with systemic lupus erythematosus (SLE) is fundamental but often difficult to make, because clinical presentation can be similar. A systematic review of all articles indexed in PubMed through October 2013 was performed, in order to examine the potenti...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审


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    更新日期:2014-09-01 00:00:00

  • Experiences of gout-related disability from the patients' perspective: a mixed methods study.

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    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: ten Klooster PM,Vonkeman HE,Voshaar MA,Bode C,van de Laar MA

    更新日期:2014-08-01 00:00:00

  • CD4+ and CD8+ subsets: naive and memory cells in the peripheral blood of patients with systemic sclerosis.

    abstract::Systemic Sclerosis (SSc; scleroderma) is associated with several immunological abnormalities, including altered proportion between lymphocyte subsets. Peripheral blood lymphocyte subsets from 25 patients with SSc were studied by two-colour flow cytometry using monoclonal antibodies against CD45RA and CD29 markers, whi...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Gorla R,Airò P,Malagoli A,Carella G,Prati E,Brugnoni D,Franceschini F,Cattaneo R

    更新日期:1994-03-01 00:00:00

  • The impact of hepatitis screening on diagnosis and treatment in rheumatoid arthritis.

    abstract::Identification of patients with exposure to viral hepatitis is an important part of the care of patients with inflammatory arthritis. This study was conducted to assess the extent of hepatitis B and C screening, and the prevalence of viral hepatitis in a cohort of patients with established rheumatoid arthritis (RA). T...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Conway R,Doran MF,O'Shea FD,Crowley B,Cunnane G

    更新日期:2014-12-01 00:00:00

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    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Dumarey N,Martin P,Jayankura M,Putz P,Verhas M,Peretz A

    更新日期:2000-01-01 00:00:00

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    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Danda S,Mohan S,Devaraj P,Dutta AK,Nampoothiri S,Yesodharan D,Phadke SR,Jalan AB,Thangaraj K,Verma IC,Danda D,Jebaraj I

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  • Action potential simulation (APS) in patients with fibromyalgia syndrome (FMS): a controlled single subject experimental design.

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    journal_title:Clinical rheumatology

    pub_type: 杂志文章,随机对照试验


    authors: Fengler RK,Jacobs JW,Bac M,van Wijck AJ,van Meeteren NL

    更新日期:2007-03-01 00:00:00

  • Clinical characteristics of peripheral spondyloarthritis without psoriasis, inflammatory enteropathy or preceding infection, from a single rheumatology clinic in northern India.

    abstract::The objective of this study was to characterise the peripheral arthritis of spondyloarthritis (pSpA) excluding psoriatic-, inflammatory enteropathy-related, post-infectious reactive-SpA and arthritis associated with axial SpA/ankylosing spondylitis (axSpA/AS). Patients presenting with the clinical features of the broa...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Malaviya AN,Agrawal N,Patil NS

    更新日期:2017-11-01 00:00:00

  • Systemic lupus erythematosus and amyloidosis.

    abstract::Amyloidosis in association with Systemic Lupus Erythematosus (SLE) has rarely been reported. We report a patient with "SLE" and Amyloidosis presenting with recurrent bloody diarrhea and review the relevant literature. ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Al-Hoqail I,Naddaf H,Al-Rikabi A,Al-Arfaj H,Al-Arfaj A

    更新日期:1997-06-01 00:00:00

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    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Yavuz S,Ece A

    更新日期:2014-05-01 00:00:00

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    journal_title:Clinical rheumatology

    pub_type: 杂志文章


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    更新日期:1986-01-01 00:00:00

  • Faraway from the silk route: demographic and clinical features of Behçet's disease in 106 Brazilian patients.

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    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Neves FS,Caldas CA,Lage LV,Goldenstein-Schainberg C,Gonçalves CR

    更新日期:2009-05-01 00:00:00

  • Syphilitic myositis: a case-based review.

    abstract::To present the clinical and pathological findings in patients presenting with myositis caused by syphilis. The literature is reviewed, and pathophysiologic factors discussed. A 49-year-old Caucasian heterosexual male with a known history of stable human immunodeficiency virus (HIV) and hepatitis C (HCV) co-infection, ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审


    authors: Yacyshyn E,Chiowchanwisawakit P,Emery DJ,Jhamandas J,Resch L,Taylor G

    更新日期:2011-05-01 00:00:00

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    abstract::The objectives of this study are to investigate the prevalence of PAD4 and anti-PAD4 antibodies (Abs) in autoimmune diseases and to clarify their association with anticitrullinated protein antibodies (ACPAs) and shared epitope (SE) in patients with rheumatoid arthritis (RA). Levels of human PAD4 and anti-PAD4 Abs in s...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Umeda N,Matsumoto I,Kawaguchi H,Kurashima Y,Kondo Y,Tsuboi H,Ogishima H,Suzuki T,Kagami Y,Sakyu T,Ishigami A,Maruyama N,Sumida T

    更新日期:2016-05-01 00:00:00

  • A follow-up study of minimally invasive lip biopsy in the diagnosis of Sjögren's syndrome.

    abstract::The aims of this study were to characterize a minimally invasive technique of minor salivary gland biopsy of the lower lip and to present a large patient material undergoing this procedure because of a suspicion of Sjögren's syndrome (SS), as well as to assess the procedure's short-term and long-term value as a diagno...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Teppo H,Revonta M

    更新日期:2007-07-01 00:00:00

  • Comparison of sexual function in Tunisian women with rheumatoid arthritis and healthy controls.

    abstract:OBJECTIVES:To evaluate sexual function in Tunisian women with rheumatoid arthritis (RA) and to compare it with that in voluntary healthy controls. METHODS:We conducted a cross-sectional study including 71 women with a confirmed diagnosis of RA according to the American College of Rheumatology/European League Against R...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Alia F,Rim BS,Miladi S,Ouenniche K,Kassab S,Chekili S,Zakraoui L,Abdelghani KB,Laatar A

    更新日期:2019-12-01 00:00:00

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    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审


    authors: Braun J,Sieper J,Bollow M

    更新日期:2000-01-01 00:00:00

  • Effect of spa therapy in Tiberias on patients with ankylosing spondylitis.

    abstract::Fourteen patients with ankylosing spondylitis (AS) were treated in a pilot study for two weeks at a Tiberias spa with a combination of hot mineral water baths and mud packs. A significant improvement was noticed in morning stiffness, finger to floor distance and the overall well-being assessment both by the patient an...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Tishler M,Brostovski Y,Yaron M

    更新日期:1995-01-01 00:00:00

  • The use of bisphosphonate in the treatment of avascular necrosis: a systematic review.

    abstract::Up to now, there is no uniformly accepted treatment for avascular necrosis (AN) that alleviates pain and retards its progression. The aim of clinical and surgical treatments is usually only to improve blood support in the avascular area. The objective of the present study was to make a systematic review of the use of ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审


    authors: Cardozo JB,Andrade DM,Santiago MB

    更新日期:2008-06-01 00:00:00