Abstract：
:Calcinosis, Raynaud's phenomenon, oesophageal dysmotility, sclerodactyly, telangiectasia (CREST) syndrome, a limited form of systemic sclerosis, is sometimes complicated by primary biliary cirrhosis (PBC). A 52- and 61-year-old Japanese woman with PBC-CREST overlap syndrome accompanied by Sjögren's syndrome, and Hashimoto's thyroiditis, and Graves' disease, respectively, are reported. They had suffered from Raynaud's phenomena, sclerodactyly, morning stiffness, arthralgia, and sicca symptoms during these several years. They exhibited an increased level of alkaline phosphatase, gamma-glutamyl transpeptidase, positive antibodies against mitochondria and centromere, and hyperglobulinemia without any cholestatic symptoms. Histological findings from liver biopsy specimens were consistent with those of PBC. Clinically, they were diagnosed as both asymptomatic PBC and incomplete CREST syndrome. Their human leukocyte antigen typing showed both DR4 and DR8 positive. The association of the four autoimmune conditions is clinically and etiologically important. Although a combination of these diseases is rare, it is of importance to keep in mind that various autoimmune diseases could occur simultaneously. Of critical importance is that an active diagnostic attitude towards them is admirable, and that early diagnosis and therapy are needed.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Nakamura T,Higashi S,Tomoda K,Tsukano M,Sugi Kdoi
10.1007/s10067-005-0178-xsubject
Has Abstractpub_date
2007-04-01 00:00:00pages
596-600issue
4eissn
0770-3198issn
1434-9949journal_volume
26pub_type
杂志文章abstract：:Paroxysmal crises of fever and systemic inflammation herald familial Mediterranean fever (FMF), considered as the archetype of all inherited systemic autoinflammatory diseases. Inflammatory bouts are characterized by short-term and self-limited abdominal, thoracic, and/or articular symptoms which subside spontaneously...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-015-2916-z
更新日期：2015-09-01 00:00:00
abstract：:Polyarteritis nodosa (PAN) is a necrotising vasculitis of medium-sized vessels of unknown origin. This type of vasculitis is usually systemic, but restriction to a single organ, for example the testis, the appendix or the gall bladder, can occur. Testicular pain or tenderness are frequent clinical features. In this re...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-008-0970-5
更新日期：2008-11-01 00:00:00
abstract：OBJECTIVES:Action potential simulation (APS) is becoming a popular method of pain reduction. Nevertheless, little is known about the efficacy of this relatively new treatment. The aim of this study was to investigate whether APS helps to reduce pain, improves patients' perception of daily functioning and social partici...
journal_title：Clinical rheumatology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10067-006-0297-z
更新日期：2007-03-01 00:00:00
abstract：:The effects of vitamin C on 1,25(OH)2D3 synthesis in humans were evaluated; the study included 20 females. They were divided into 2 groups. The first of the 10 subjects (age range 55-71) received ascorbic acid at a dose of 150 mg/die i.v. for 10 days; the second 10 subjects (age range 55-69) received a placebo i.v. fo...
journal_title：Clinical rheumatology
pub_type： 临床试验,杂志文章
doi：10.1007/BF02207657
更新日期：1991-06-01 00:00:00
abstract：:Innate immunity has been widely accepted as one of the major cause for the alteration of immune system and progression of autoimmune diseases. Natural killer (NK) cells and natural killer T (NKT) cells have not been explored in clinical studies for their cytolytic components in association with rheumatoid arthritis (R...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-014-2641-z
更新日期：2014-08-01 00:00:00
abstract：:The objectives of the study were to assess sleep disturbances in systemic lupus erythematosus (SLE) and to compare these with a working sample and a treatment-seeking sample reporting insomnia. The primary sample was 172 people with SLE. This sample represented 32% of all members of two lupus support association. Two ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-008-0884-2
更新日期：2008-09-01 00:00:00
abstract：:Behcet's disease (BD) is a systemic vasculitis characterized by genital and oral ulcers, uveitis, and other organs' involvement. Left ventricular (LV) diastolic dysfunction has been documented in BD. However, conventional echocardiographic techniques have serious limitations like its dependence on preload, afterload a...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-006-0208-3
更新日期：2006-11-01 00:00:00
abstract：:The objective of this study was to analyze the clinical, laboratorial, and therapeutical response of polymyalgia rheumatica (PMR) to anti-tumor necrosis factor (anti-TNF) treatment. We systematically searched English articles on the subjects of PMR who were treated with TNF blockers in Pubmed from 1994 to 2010. In add...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-011-1914-z
更新日期：2012-03-01 00:00:00
abstract：:The aim of this research was to determine any correlations between Dickkopf-1 serum levels (Dkk-1, a natural inhibitor of the Wnt signaling pathway promoting osteoclastogenesis) and the Trabecular Bone Score (TBS), in systemic sclerosis (SSc) and rheumatoid arthritis (RA) patients. It also aimed at determining any dif...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-018-4322-9
更新日期：2018-11-01 00:00:00
abstract：:A 62-year-old man who suffered from severe deforming arthritis, secondary to chronic tophaceous gout with multilobular, solid, tender, enlarged subcutaneous nodules, and draining tophi in right second finger, was treated by free flap and finally got the more functional and aesthetic result. ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-009-1321-x
更新日期：2010-03-01 00:00:00
abstract：:Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a wide range of manifestations and potential to affect several organ systems. Complications arise from both disease and medications especially glucocorticoids, significantly contributing to overall morbidity and mortality. SLE predominantly affect...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-019-04795-9
更新日期：2020-03-01 00:00:00
abstract：:In a Sidonian sarcophagus, from the Late Antique/early Christian period, skeletal remains of two persons were found. One of them, male, 30-50 years old, was found almost completely ankylosed, with highly osteoporotic bones and prominent erosion of joint surfaces. We diagnosed rheumatoid arthritis based on the eroded o...
journal_title：Clinical rheumatology
pub_type： 历史文章,杂志文章
doi：10.1007/s10067-016-3493-5
更新日期：2017-01-01 00:00:00
abstract：:This paper presents the first reported case of risedronate-associated scleritis and conducts a review of bisphosphonates and inflammatory eye diseases. A case of scleritis associated with risedronate use in a 73-year-old Chinese woman is reported. The English medical literature was reviewed for bisphosphonates and the...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-012-2035-z
更新日期：2012-09-01 00:00:00
abstract：PURPOSE:To explore the 18F-fluoro-dexoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) imaging characteristics of adult-onset Still's disease (AOSD) and its significance in differential diagnosis from other connective tissue diseases (CTDs). METHODS:FDG PET/CT images of 54 patients with AOSD...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05041-3
更新日期：2020-09-01 00:00:00
abstract：:Transient receptor potential melastatin 7 (TRPM7) is involved in both normal physiological processes and pathology of various diseases. The purpose of this study was to explore the function and underlying mechanisms of TRPM7 channels in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLSs) apoptosis induced by...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-014-2599-x
更新日期：2014-11-01 00:00:00
abstract：OBJECTIVE:This study aimed to identify the clinical characteristics of systemic lupus erythematosus-primary biliary cholangitis (SLE-PBC) patients and to compare the manifestations and prognosis with systemic lupus erythematosus (SLE) patients. METHODS:Twenty-one inpatients with concomitant SLE and primary biliary cho...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05457-x
更新日期：2020-10-16 00:00:00
abstract：:Tissue plasminogen activator (tPA), plasminogen activator inhibitor-1 (PAI-1) and von Willebrand factor (vWF), all of endothelial origin and active in the haemostasis, were analysed in 74 patients with rheumatoid arthritis. The concentrations were related to extra-articular disease and to the incidence of thromboembol...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02231572
更新日期：1993-09-01 00:00:00
abstract：:Anti-nucleosome antibodies, which recognise conformational epitopes consisting of histone and DNA in chromatin, have been described in autoimmune diseases. In this study, an attempt was made to isolate anti-nucleosome antibodies from the anti-DNA-depleted plasma IgG of two lupus patients either with or without nephrit...
journal_title：Clinical rheumatology
pub_type： 临床试验,杂志文章
doi：10.1007/BF01451045
更新日期：1998-01-01 00:00:00
abstract：OBJECTIVES:To test the psychometric properties of the United Kingdom's Commissioning for Quality in Rheumatoid Arthritis Patient-Reported Experience Measure (CQRA-PREM) in patients with spondyloarthritis (SpA) and rheumatoid arthritis (RA) and to implement this questionnaire in daily practice in the Netherlands. METHO...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05076-6
更新日期：2020-10-01 00:00:00
abstract：:A case of polymyositis associated with scleroderma, adult coeliac disease, diabetes mellitus and IgA nephropathy is reported in a 33-year-old male. ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02031278
更新日期：1984-12-01 00:00:00
abstract：INTRODUCTION:Antibody against cyclic citrullinated protein (ACPA) is counted as one of the most important biomarkers in diagnosis, classification, and prognosis of rheumatoid arthritis (RA). We examined the evolution of ACPA during disease course and assess predictive value of time-weighted cumulative ACPA titer on rad...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-019-04554-w
更新日期：2019-09-01 00:00:00
abstract：OBJECTIVES:The aim of this study is to analyze the prevalence of myositis-specific autoantibodies (MSAs) and to elucidate their associations with clinical features in Chinese patients with polymyositis (PM) and dermatomyositis (DM). METHODS:Twelve subsets of MSAs including anti-Mi-2, anti-TIF1-γ, anti-MDA5, anti-NXP2,...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-019-04503-7
更新日期：2019-08-01 00:00:00
abstract：:The objective of this work was to study the clinical and serological profiles of rheumatoid arthritis in Burkina Faso (West Africa). It is a cross-sectional study conducted from March 2006 to February 2009 in the Internal Medicine Department of the University Hospital Yalgado Ouedraogo. All patients seen in the rheuma...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-011-1831-1
更新日期：2011-12-01 00:00:00
abstract：:The aims of our study are to observe the pregnancy outcome of anti-Sjögren's syndrome-related antigen A (SSA)/Ro-positive women and to predict the risk factors for adverse pregnancy outcome and neonatal lupus erythematosus (NLE). Clinical data of 126 anti-SSA/Ro-positive patients with 140 pregnancies were evaluated re...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-015-3050-7
更新日期：2015-10-01 00:00:00
abstract：:We described a 21-year-old woman with a diagnosis of Sjögren syndrome that came for consultation with a localized mass over her left arm of fast growth. Lab results were normal; a Doppler ultrasound showed the presence of partial thrombosis in the left axillary vein; a magnetic resonance imaging showed edema on the bi...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-015-3133-5
更新日期：2016-04-01 00:00:00
abstract：:The relationship of TNF-alpha promoter polymorphisms and ankylosing spondylitis (AS) has been reported with conflicting results. We perform this meta-analysis to collect all the relevant studies up to date to further clarify the association of TNF-alpha promoter polymorphisms with AS. A review was conducted of studies...
journal_title：Clinical rheumatology
pub_type： 杂志文章,meta分析
doi：10.1007/s10067-010-1499-y
更新日期：2010-09-01 00:00:00
abstract：:Sustained cough is a frequent complaint in methotrexate (MTX) treatment for rheumatoid arthritis and can be a symptom of incipient MTX-induced pneumonitis. This study was performed to characterize MTX-associated cough clinically and to clarify by which means this condition can be distinguished from incipient MTX pneum...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02229707
更新日期：1996-05-01 00:00:00
abstract：OBJECTIVE:To compare effectiveness of ultrasound-guided local insulin injection, local steroid injection, and local steroid followed by insulin injections in treating mild to moderate carpal tunnel syndrome (CTS) in type 2 diabetes mellitus (DM). METHOD:Study included 60 patients with electrophysiologic evidence of mi...
journal_title：Clinical rheumatology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10067-019-04638-7
更新日期：2019-10-01 00:00:00
abstract：:Type B insulin resistance syndrome is characterized by the formation of autoantibodies against insulin receptors, which can cause severe hyperglycemia and insulin resistance. Systemic lupus erythematosus is the most common underlying diseases of the syndrome. This report details our study of a case involving a Chinese...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-012-2098-x
更新日期：2013-02-01 00:00:00
abstract：:Scleredema (also called scleredema of Buschke) is a fibromucinous connective tissue disorder of unknown cause that belongs to a group of scleroderma-like disorders. We report the case of a 64-year-old lady with long-standing scleredema, associated with a paraprotein, and progressing to multiple myeloma and AL amyloido...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-004-1076-3
更新日期：2006-02-01 00:00:00
