Inhibition of transient receptor potential melastatin 7 (TRPM7) channel induces RA FLSs apoptosis through endoplasmic reticulum (ER) stress.

abstract：:In the study of pathophysiological mechanisms in growth abnormalities of the juvenile knee in arthritis an animal model in dogs was developed. Arthritis was induced by intra-articular injections of Carrageenan. Prominent growth changes were enlargement of the distal femoral epiphysis, patellar squaring and decreased e...

journal_title：Clinical rheumatology

authors： Bunger C,Bunger EH,Harving S,Djurhuus JC,Jensen OM

更新日期：1984-06-01 00:00:00

abstract：:This paper is to assess the efficacy of different biologic DMARDs (bDMARDs) on several patient-reported outcomes (PROs) in randomized controlled trials (RCT) in axial spondyloarthritis (axSpA). A systematic literature review (SLR) was performed. MEDLINE (May 1, 2018) was used with the filters "published in the last 10...

journal_title：Clinical rheumatology

authors： Rodrigues-Manica S,Silva J,Cruz-Machado R,Coelho C,Duarte J,Vieira-Sousa E,Tavares-Costa J,Pimentel-Santos FM

更新日期：2021-01-01 00:00:00

abstract：:The use of biotechnology-derived medicines has significantly increased in recent decades. Although biosimilars undergo rigorous characterization as well as clinical studies to document their safety and effectiveness, they are highly complex molecules and small changes in the purification and production process of a bi...

journal_title：Clinical rheumatology

authors： Pineda C,Caballero-Uribe CV,de Oliveira MG,Lipszyc PS,Lopez JJ,Mataos Moreira MM,Azevedo VF

更新日期：2015-04-01 00:00:00

abstract：:A cohort of patients with recently diagnosed axial spondyloarthritis (SpA) was characterized with emphasis on gender differences and factors leading to delay in diagnosis. Clinical, laboratory, and imaging data of 151 consecutive patients diagnosed with ankylosing spondylitis or undifferentiated SpA in 2004-2009 and s...

journal_title：Clinical rheumatology

authors： Slobodin G,Reyhan I,Avshovich N,Balbir-Gurman A,Boulman N,Elias M,Feld J,Mader R,Markovitz D,Rimar D,Rosner I,Rozenbaum M,Zisman D,Odeh M

更新日期：2011-08-01 00:00:00

abstract：:This study aims to examine the needs and preferences regarding the delivery of health care services and information provision and their determinants in patients with systemic sclerosis (SSc). A questionnaire was sent to 77 SSc outpatients, comprising 27 items on health care needs within the domains physical, psycholog...

journal_title：Clinical rheumatology

authors： Schouffoer AA,Zirkzee EJ,Henquet SM,Caljouw MA,Steup-Beekman GM,van Laar JM,Vlieland TP

更新日期：2011-06-01 00:00:00

abstract：:The aim of this study was to evaluate if pulsed electromagnetic field therapy (PEMF) has additional effect on the classical physical treatment of knee osteoarthritis (OA) composed of hot pack, therapeutic ultrasound, and terminal isometric exercises. Forty patients (29 women and 11 men), ages 44 to 78 (mean age was 61...

journal_title：Clinical rheumatology

authors： Ozgüçlü E,Cetin A,Cetin M,Calp E

更新日期：2010-08-01 00:00:00

abstract：:Sjõgren's disease is one of the most common rheumatological diseases and can present with a variety of extra-glandular manifestations. Lymphocytic Interstitial Pneumonitis (LIP) is the most common lung pathology in these patients. It is important to know and recognize this condition because it is potentially treatable...

journal_title：Clinical rheumatology

authors： Dalvi V,Gonzalez EB,Lovett L

更新日期：2007-08-01 00:00:00

abstract：:Infection is a major cause of morbidity and mortality among patients with systemic lupus erythematosus (SLE). To describe the pattern of serious infections in patients with SLE and to identify the predictors of infection-related mortality among SLE patients with serious infections, we prospectively studied all SLE pat...

journal_title：Clinical rheumatology

authors： Teh CL,Wan SA,Ling GR

更新日期：2018-08-01 00:00:00

abstract：:In the past decade, lung ultrasound (LUS) B-lines and serum Krebs von den Lungen-6 (KL-6) antigen have been recognized as biomarkers of the connective tissue disease-associated interstitial lung diseases (CTD-ILDs). Robust data have demonstrated that B-lines total numbers and KL-6 levels are correlated with high-resol...

journal_title：Clinical rheumatology

authors： Wang Y,Chen S,Lin Z,Lin J,Xie X,Lin Q,Du G,Huang X,Matucci-Cerinic M,Furst DE

更新日期：2019-05-01 00:00:00

abstract：:This paper presents the first reported case of risedronate-associated scleritis and conducts a review of bisphosphonates and inflammatory eye diseases. A case of scleritis associated with risedronate use in a 73-year-old Chinese woman is reported. The English medical literature was reviewed for bisphosphonates and the...

journal_title：Clinical rheumatology

authors： Hemmati I,Wade J,Kelsall J

更新日期：2012-09-01 00:00:00

abstract：:Belimumab is an effective and safe treatment option for systemic lupus erythematosus (SLE). However, data on treatment cessation are lacking. Thus, we investigated belimumab-free remission in SLE patients. SLE patients receiving belimumab in our institute (May 1, 2013-May 31, 2019) were retrospectively identified usin...

journal_title：Clinical rheumatology

authors： Nakai T,Fukui S,Ikeda Y,Shimizu H,Tamaki H,Okada M

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVE:We aimed to evaluate the effect on renal functions and blood pressure of the addition of low dose aspirin (LDA) to cyclooxygenase-2 (COX-2) inhibitors or nonselective NSAIDs. METHODS:Two groups each containing 14 patients with one group using celecoxib and the other indomethacin regularly for at least 1 week...

journal_title：Clinical rheumatology

authors： Pamuk ON,Cakir N

更新日期：2006-02-01 00:00:00

abstract：:The objective of this study was to determine possible differences in the outcome of patients with rheumatoid arthritis (RA) with disease onset early and late in life. As part of a broader outcome study of RA which included patients seen in the division of Rheumatology of Hospital Universitario Marqués de Valdecilla of...

journal_title：Clinical rheumatology

authors： Calvo-Alén J,Corrales A,Sánchez-Andrada S,Fernández-Echevarría MA,Peña JL,Rodríguez-Valverde V

更新日期：2005-09-01 00:00:00

abstract：OBJECTIVES:Decreased natural killer (NK) cells have been reported in systemic lupus erythematosus (SLE) patients. However, the role of NK cells in the pathogenesis of SLE is not well understood. In this study, we aimed to characterize NK cell subsets, phenotypes, and cytokine-secreting functions and investigate the cli...

journal_title：Clinical rheumatology

authors： Liu M,Liu J,Zhang X,Xiao Y,Jiang G,Huang X

更新日期：2020-08-14 00:00:00

abstract：INTRODUCTION/OBJECTIVE:Knee alignment and anterior cruciate ligament (ACL) injury are risk factors for knee osteoarthritis (OA). The objective was to examine interactions between knee alignment and ACL status on cartilage volume loss in participants with or at risk of knee OA. METHOD:Participants were from the Osteoar...

journal_title：Clinical rheumatology

authors： Robbins SM,Raymond N,Abram F,Pelletier JP,Martel-Pelletier J

更新日期：2019-12-01 00:00:00

abstract：:Muscle pain and weakness in a rheumatoid arthritis (RA) patient has a broad differential, and myositis should be considered early in the disease course as serious limb and life-threatening sequelae may occur. A 55-year-old woman with a past medical history of methotrexate-controlled RA presented with right leg pain fo...

journal_title：Clinical rheumatology

authors： Jo D,Pompa T,Khalil A,Kong F,Wetz R,Goldstein M

更新日期：2015-10-01 00:00:00

abstract：:A 62-year-old man who suffered from severe deforming arthritis, secondary to chronic tophaceous gout with multilobular, solid, tender, enlarged subcutaneous nodules, and draining tophi in right second finger, was treated by free flap and finally got the more functional and aesthetic result. ...

journal_title：Clinical rheumatology

authors： Lee KS,Lee HS,Kim NG,Kim JS,Lee SI,Choi TH

更新日期：2010-03-01 00:00:00

abstract：:Our aim is to investigate the effects of three therapeutic approaches in the chronic low back pain on pain, spinal mobility, disability, psychological state, and aerobic capacity. Sixty patients with chronic low back pain were randomized to three groups: group 1, aerobic exercise + home exercise; group 2, physical the...

journal_title：Clinical rheumatology

authors： Koldaş Doğan S,Sonel Tur B,Kurtaiş Y,Atay MB

更新日期：2008-07-01 00:00:00

abstract：:Ophthalmic involvement is the most debilitating complication of Behcet's disease (BD). The aim of the current study is to report on the efficacy and safety of a long-term use of interferon alpha-2a (IFNα-2a) in the treatment of refractory ophthalmic BD in the Azari population of Iran. We retrospectively analyzed the c...

journal_title：Clinical rheumatology

authors： Kavandi H,Khabbazi A,Kolahi S,Hajialilo M,Shayan FK,Oliaei M

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:The association between pyoderma gangrenosum (PG) and rheumatoid arthritis (RA) was not investigated in the setting of controlled studies. The risk of PG among patients with RA is not established. OBJECTIVE:The study aims to evaluate the magnitude of the association between RA and the subsequent development...

journal_title：Clinical rheumatology

authors： Kridin K,Damiani G,Cohen AD

更新日期：2021-02-01 00:00:00

abstract：:Behçet's disease is a multisystem disorder affecting the skin, mucous membranes, eye, joints, central nervous system, and blood vessels. One of the known vascular complications of Behçet's disease is venous thrombosis or aneurysm formation. We report, herewith, a patient with Behçet's disease who developed radial arte...

journal_title：Clinical rheumatology

authors： el-Asrar AM,al-Momen AK,Alamro SA,Gader AG,Tabbara KF

更新日期：1996-09-01 00:00:00

abstract：:The objectives of this paper are to evaluate the efficacy of a community-based lay-led Arthritis Self-Management Program (ASMP) among patients with chronic inflammatory arthritis and evaluate the effectiveness of "shared care collaboration" between hospital and community. We trained 17 lay leaders and recruited patien...

journal_title：Clinical rheumatology

authors： Leung YY,Kwan J,Chan P,Poon PK,Leung C,Tam LS,Li EK,Kwok A

更新日期：2016-04-01 00:00:00

abstract：:The study aimed to determine the serum level of glucocorticoid-induced tumor necrosis factor receptor family-related protein ligand (GITRL) in patients with rheumatoid arthritis (RA) and investigate its clinical significance. GITRL levels were measured by enzyme-linked immunosorbent assay (ELISA) in 88 RA patients, 20...

journal_title：Clinical rheumatology

authors： Li L,Wen W,Jia R,Li Y,Liu X,Sun X,Li Z

更新日期：2016-09-01 00:00:00

abstract：:Erdheim-Chester disease (ECD) is a disseminated non-Langerhans' cell histiocytosis with multisystem involvement, including characteristic sclerotic musculoskeletal lesions. We present the case of a 27-year-old woman with a fulminant course and atypical involvement by ECD manifesting as extensive cerebrovascular diseas...

journal_title：Clinical rheumatology

authors： Lyders EM,Kaushik S,Perez-Berenguer J,Henry DA

更新日期：2003-12-01 00:00:00

abstract：:Amyloid arthropathy is said to be distinguished roentgenographically from rheumatoid arthritis by the absence of joint space narrowing and the absence of articular erosions. We present a patient with multiple myeloma with swelling, stiffness and firm synovial thickening of the wrists, metacarpophalangeal joints and pr...

journal_title：Clinical rheumatology

authors： Leonard PA,Clegg DO,Lee RG

更新日期：1985-06-01 00:00:00

abstract：:It has been well established that, anti-thyroglobulin antibodies (ATG) and anti-microsomal antibodies (AMC) may be present in various thyroid disorders and other systemic autoimmune diseases, including Sjögren's syndrome (SS). However, presence of circulating autoantibodies to thyroid hormones, i.e. both to triiodothy...

journal_title：Clinical rheumatology

authors： Ozgen AG,Keser G,Erdem N,Aksu K,Gümüsdis G,Kabalak T,Doganavsargil E

更新日期：2001-01-01 00:00:00

abstract：:Delayed diagnosis in patients with Churg-Strauss syndrome (CSS) is largely attributed to the variable and nonspecific presentation of the disease's initial symptoms. The aim of the study was to evaluate the effect of delayed diagnosis on the course of CSS. We conducted a retrospective study of 30 CSS patients followed...

journal_title：Clinical rheumatology

authors： Sokołowska B,Szczeklik W,Mastalerz L,Kuczia P,Wodkowski M,Stodółkiewicz E,Macioł K,Musiał J

更新日期：2013-03-01 00:00:00

abstract：INTRODUCTION:Alkaptonuria (AKU) is a rare metabolic disease. The global incidence is 1:100,000 to 1:250,000. However, identification of a founder mutation in a gypsy population from India prompted us to study the prevalence of AKU in this population and to do molecular typing in referred cases of AKU from the rest of I...

journal_title：Clinical rheumatology

authors： Danda S,Mohan S,Devaraj P,Dutta AK,Nampoothiri S,Yesodharan D,Phadke SR,Jalan AB,Thangaraj K,Verma IC,Danda D,Jebaraj I

更新日期：2020-09-01 00:00:00

abstract：:To demonstrate an as yet merely postulated generalized osteopathy in psoriatics, the serum calcium level, the alkaline phosphatase in the serum and the urinary excretion of hydroxyproline were evaluated in 24 patients with Ps and 24 patients with PA. Moreover, the bone bioptates from 25 patients with PA and 10 patient...

journal_title：Clinical rheumatology

authors： Hein G,Abendroth K,Müller A,Wessel G

更新日期：1991-03-01 00:00:00

abstract：:Systemic Sclerosis (SSc; scleroderma) is associated with several immunological abnormalities, including altered proportion between lymphocyte subsets. Peripheral blood lymphocyte subsets from 25 patients with SSc were studied by two-colour flow cytometry using monoclonal antibodies against CD45RA and CD29 markers, whi...

journal_title：Clinical rheumatology

authors： Gorla R,Airò P,Malagoli A,Carella G,Prati E,Brugnoni D,Franceschini F,Cattaneo R

更新日期：1994-03-01 00:00:00