Abstract:
:Systemic Sclerosis (SSc; scleroderma) is associated with several immunological abnormalities, including altered proportion between lymphocyte subsets. Peripheral blood lymphocyte subsets from 25 patients with SSc were studied by two-colour flow cytometry using monoclonal antibodies against CD45RA and CD29 markers, which allow a dissection of CD4+ and CD8+ populations into 'naive' and 'memory' subsets. A decrease of the percentage of CD8+ (p < 0.05) and of CD8+CD29+ (p < 0.001) cells was observed compared to that in 20 age and sex-matched controls. These abnormalities were not significantly associated with the extension of cutaneous disease or other clinical features of SSc nor with treatment, pattern of autoantibodies or HLA phenotype.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Gorla R,Airò P,Malagoli A,Carella G,Prati E,Brugnoni D,Franceschini F,Cattaneo Rdoi
10.1007/BF02229871subject
Has Abstractpub_date
1994-03-01 00:00:00pages
83-7issue
1eissn
0770-3198issn
1434-9949journal_volume
13pub_type
杂志文章abstract::A cohort of patients with recently diagnosed axial spondyloarthritis (SpA) was characterized with emphasis on gender differences and factors leading to delay in diagnosis. Clinical, laboratory, and imaging data of 151 consecutive patients diagnosed with ankylosing spondylitis or undifferentiated SpA in 2004-2009 and s...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-011-1719-0
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVE:To investigate the clinical characteristics, laboratory features, and treatment outcomes of Thai patients compared between those with necrotizing autoimmune myopathy (NAM) and those with other idiopathic inflammatory myopathies (IIMs) or non-NAM. METHODS:This multicenter case-control study included patients ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,多中心研究
doi:10.1007/s10067-019-04756-2
更新日期:2019-12-01 00:00:00
abstract::The higher incidence of arterial and venous events is well established in patients with rheumatoid arthritis (RA). Our aim here was to investigate whether there is a prothrombotic state in RA patients by using rotational thromboelastometry (ROTEM) method and to demonstrate whether the disease variables play a role in ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4134-y
更新日期:2018-09-01 00:00:00
abstract::The study aimed to determine the serum level of glucocorticoid-induced tumor necrosis factor receptor family-related protein ligand (GITRL) in patients with rheumatoid arthritis (RA) and investigate its clinical significance. GITRL levels were measured by enzyme-linked immunosorbent assay (ELISA) in 88 RA patients, 20...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-016-3280-3
更新日期:2016-09-01 00:00:00
abstract::Fourteen patients with ankylosing spondylitis (AS) were treated in a pilot study for two weeks at a Tiberias spa with a combination of hot mineral water baths and mud packs. A significant improvement was noticed in morning stiffness, finger to floor distance and the overall well-being assessment both by the patient an...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02208080
更新日期:1995-01-01 00:00:00
abstract::The aim of this study was to evaluate whether modifiable cardiovascular disease (CVD) risk factors, e.g. atherogenic blood lipids, hypertension and lifestyle-related factors such as smoking, diet and physical inactivity, differ among patients with ankylosing spondylitis (AS) in comparison to the general population. Ei...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-013-2410-4
更新日期:2014-01-01 00:00:00
abstract::We report two cases of a full-thickness rotator cuff tear followed by acromioclavicular cyst formation in patients with longstanding erosive polyarticular rheumatoid arthritis. One of the consequences of a rotator cuff tear is articular instability with upward migration of the humeral head. The ensuing chronic frictio...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF01452269
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:MicroRNAs (miRNAs) regulate gene expression and are disease biomarkers. Rheumatoid arthritis (RA) patients have accelerated atherosclerosis leading to excess cardiovascular morbidity and mortality, but traditional risk factors for cardiovascular risk stratification are inadequate. In the general population, m...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05573-8
更新日期:2021-01-02 00:00:00
abstract::Although mesenteric vasculitis due to Henoch-Schönlein purpura (HSP) is relatively uncommon, it is the most life-threatening manifestation associated with high mortality. We describe a 15-year-old boy with HSP who had massive gastrointestinal bleeding and ileus but delayed onset of the purpuric rash. Abdominal ultraso...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-002-0676-z
更新日期:2003-05-01 00:00:00
abstract::The objectives of this study are to assess the risk of asymptomatic cranial neuropathy among patients with systemic lupus erythematosus (SLE) and find any association with disease activity and antiribosomal P antibodies. This study is a case-control study including 60 female patients and 30 healthy female controls. Di...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-014-2679-y
更新日期:2014-01-01 00:00:00
abstract::The objective of this study was to characterise the peripheral arthritis of spondyloarthritis (pSpA) excluding psoriatic-, inflammatory enteropathy-related, post-infectious reactive-SpA and arthritis associated with axial SpA/ankylosing spondylitis (axSpA/AS). Patients presenting with the clinical features of the broa...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3720-8
更新日期:2017-11-01 00:00:00
abstract::We present a patient with previously diagnosed hypocomplementemic urticarial vasculitis syndrome, with skin, lung, and renal involvement, who presented with congestive cardiac failure. During the course of her hospitalization, she was also found to have profound proximal muscle weakness in both upper and lower limbs a...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-006-0397-9
更新日期:2007-08-01 00:00:00
abstract::Knee osteoarthritis (KOA) is a common degenerative joint disease causing pain, stiffness, reduced motion, swelling, crepitus, and disability. Several inflammatory markers and cartilage degradation products can be used as biomarkers in OA. The key factors of bone metabolism in normal joint bone, dickkopf-1 (DKK1) and o...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3690-x
更新日期:2017-10-01 00:00:00
abstract::Intravenous immunoglobulin (IVIg) is currently used with much enthusiasm for the treatment of many autoimmune diseases, including systemic lupus erythematosus (SLE). Among its various indications, IVIg has also been found to be beneficial in myocarditis, whether or not it is associated with an autoimmune disease (e.g....
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670050091
更新日期:1999-01-01 00:00:00
abstract::Neurological involvement is uncommon in systemic sclerosis. Most of the reported cases concern trigeminal neuropathy or peripheral nerve entrapment. We report a third case of brachial plexopathy, presumably related to vasculitis, in a patient with systemic sclerosis, which improved after cyclophosphamide therapy. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670200106
更新日期:2002-09-01 00:00:00
abstract::The involvement of brain-derived neurotrophic factor (BDNF) in rheumatoid arthritis (RA) is largely unknown. The distribution of BDNF and its associated receptors, TrkB and p75, in the synovial tissue of patients with RA was examined and contrasted with that in patients with osteoarthritis (OA). Additionally, levels o...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-008-0910-4
更新日期:2008-10-01 00:00:00
abstract::Idiopathic retroperitoneal fibrosis (IRPF) is a rare condition of unknown aetiology characterized by chronic non-specific inflammation of the retroperitoneum. The aim of this study is to describe, for the first time, the features of Spanish patients with IRPF. In this retrospective study, a clinical description was pe...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-013-2225-3
更新日期:2013-06-01 00:00:00
abstract::Interferon regulatory factor 5 (IRF5) is a member of IRF family which induce signaling pathways and are involved in modulation of cell growth, differentiation, apoptosis, and immune system activity. Juvenile idiopathic arthritis (JIA) is an auto-inflammatory syndrome where the inflammatory markers are believed to play...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4010-9
更新日期:2018-10-01 00:00:00
abstract::To compare rheumatologists' adherence to treatment protocols for rheumatoid arthritis (RA) targeted at Disease Activity Score (DAS) ≤2.4 or <1.6. The BeSt-study enrolled 508 early RA (1987) patients targeted at DAS ≤2.4. The IMPROVED-study included 479 early RA (2010) and 122 undifferentiated arthritis patients target...
journal_title:Clinical rheumatology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s10067-016-3405-8
更新日期:2017-02-01 00:00:00
abstract::The signalling lymphocyte activation molecule (SLAM) family receptors play important roles in modulating immune responses. Previous studies in murine models and patients have suggested an association of the SLAM family (SLAMF) members with the development of autoimmunity, particularly systemic lupus erythematosus (SLE...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3698-2
更新日期:2018-03-01 00:00:00
abstract::Functional limitation is often complained by patients with ankylosing spondylitis (AS). With a rising number of patients suffering from AS, there are a limited number of reports focusing on functional limitation of AS in Chinese patients. This study was conducted to investigate the level of functional limitation and e...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3563-3
更新日期:2017-04-01 00:00:00
abstract::Catastrophic anti-phospholipid syndrome (CAPS) is a medical emergency characterized by thromboses of multiple small vessels of internal organs and the brain. Herein we present a patient with primary anti-phospholipid syndrome who developed CAPS manifested by hepatic, renal and splenic artery thromboses, as well as cer...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-005-0017-0
更新日期:2006-05-01 00:00:00
abstract::The high concentrations of pro-inflammatory prostaglandins (PGs) produced in the joint during the initial stage of inflammation can be decreased by inhibiting their biosynthesis with nonsteroidal anti-inflammatory drugs (NSAIDs). The commonly encountered gastrointestinal intolerance in human subjects treated with NSAI...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02214106
更新日期:1989-03-01 00:00:00
abstract::A case of polymyositis associated with scleroderma, adult coeliac disease, diabetes mellitus and IgA nephropathy is reported in a 33-year-old male. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02031278
更新日期:1984-12-01 00:00:00
abstract::We investigated, in retrospect, if there were differences in the frequency and types of abdominal surgery between newly diagnosed female fibromyalgia (n = 80) and rheumatoid arthritis (n = 47) patients performed before the formal diagnosis. There was no difference in the total number of abdominal operations between bo...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670050042
更新日期:1999-01-01 00:00:00
abstract::Eighty patients with Reiter's syndrome (RS) were studied retrospectively. A comparison was made between patients with the complete syndrome and patients with the incomplete syndrome. A comparison was also made between patients with and without HLA-B27. There were no major differences in severity and duration of the ar...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02030971
更新日期:1986-01-01 00:00:00
abstract::Adropin, a secreted protein, is encoded by the energy homeostasis associated (ENHO) gene. It has been implicated in the several physiological and pathological processes such as angiogenesis and apoptosis. Therefore, the aim of present study was to investigate serum adropin levels and ENHO gene expressions in systemic ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-016-3266-1
更新日期:2016-06-01 00:00:00
abstract::Children with juvenile idiopathic arthritis (JIA) may infrequently present with localized anterior knee pain or swelling, in addition to generalize knee pain induced by JIA. We report five cases of deep infrapatellar bursitis in children with JIA. The clinical features, radiological findings, management, and outcome o...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-010-1620-2
更新日期:2011-02-01 00:00:00
abstract::Expectancies play a major role for the treatment outcome of a broad variety of immune-mediated conditions and may strengthen or mimic the effects of regular long-term therapies. This study adds to a recently published study of Kox et al. (PNAS 111:7379-7384, 2014) on the ability to voluntarily influence the physiologi...
journal_title:Clinical rheumatology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10067-015-3009-8
更新日期:2016-04-01 00:00:00
abstract::This study aimed to investigate the effects of colchicine on growth parameters in familial Mediterranean fever (FMF) patients. Fifty-one (29 girls, 22 boys) FMF patients were enrolled in the study. All of the patients were in the prepubertal stage and had not received colchicine treatment before the study. Anthropomet...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-015-3077-9
更新日期:2016-06-01 00:00:00