Abstract：
:This paper presents the first reported case of risedronate-associated scleritis and conducts a review of bisphosphonates and inflammatory eye diseases. A case of scleritis associated with risedronate use in a 73-year-old Chinese woman is reported. The English medical literature was reviewed for bisphosphonates and their association with inflammatory eye diseases. Cases of ocular inflammation in patients taking bisphosphonates have been reported since the early 1990s. Reported cases include both nitrogen- and non-nitrogen-containing bisphosphonates and with both intravenous and oral use. We report the first case of risedronate-induced scleritis. The case involves a 73-year-old woman who developed scleritis following exposure to risedronate in 2007 with recurrence of scleritis upon risedronate exposure again in 2009. Discontinuation of risedronate and treatment with intravenous and topical corticosteroids resulted in both clinical and radiological improvements within 24 h. Applying Naranjo's adverse drug reaction probability scale, a causality assessment was made which categorized this reaction as definite with a score of 9. In our case, there was a strong causal relationship between the use of risedronate and scleritis. Although rare, ocular adverse effects of bisphosphonates may be serious and should be made known to prescribing physicians. This is important in the practice of rheumatology as many of the patients are prescribed this class of medication for either prevention or treatment of osteoporosis. Moreover, ocular inflammation can be a sign of systemic disease, and such patients may be referred to a rheumatologist.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Hemmati I,Wade J,Kelsall Jdoi
10.1007/s10067-012-2035-zsubject
Has Abstractpub_date
2012-09-01 00:00:00pages
1403-5issue
9eissn
0770-3198issn
1434-9949journal_volume
31pub_type
杂志文章,评审abstract：:The presence of nail changes was investigated in 102 patients with nodal osteoarthritis of the hand. Nail lesions were seen in 14/102 patients (13.7%), a prevalence higher than that observed in 96 controls (4/96, 4.2%; chi square 4.37, p = 0.036). An increased risk of nail changes was associated with osteoarthritis of...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02249013
更新日期：1994-06-01 00:00:00
abstract：:Biological agents, particularly anti-Tumour Necrosis Factor (TNF)-α agents, have emerged as an effective treatment in patients with chronic inflammatory diseases. An association between anti-TNF-α antibodies and reactivation of latent tuberculosis infection (LTBI) has been established. Appropriate screening for TB inf...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-012-1938-z
更新日期：2012-05-01 00:00:00
abstract：:Biologic therapies have brought improved efficacy in the field of rheumatoid arthritis (RA), but their use in clinical practice may be limited by concerns over cost. Predictive models are, therefore, needed to identify those people with RA with the worst potential outcomes, who will benefit most from the use of these ...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-010-1639-4
更新日期：2011-03-01 00:00:00
abstract：:The relationship between ankylosing spondylitis and the recently proposed entity called axial spondyloarthritis with its radiographic and non-radiographic forms that have been defined by the Assessment of Spondyloarthritis International Society (ASAS) criteria for axial spondyloarthritis (axSpA), is currently being de...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-016-3261-6
更新日期：2016-06-01 00:00:00
abstract：OBJECTIVES:There are no pharmacovigilance studies on adverse event (AE) data for tumour necrosis factor alpha (TNFα) inhibitors in South Korea. We analysed AEs induced by adalimumab, infliximab, and etanercept METHODS: We used data from the Korea Institute of Drug Safety and Risk Management-Korea Adverse Events Reporti...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-019-04802-z
更新日期：2020-02-01 00:00:00
abstract：:The objective of the study was to analyze the prognostic factors of radiographic progression in a series of patients with early rheumatoid arthritis (RA) after 2 years of therapy with a structured algorithm using disease-modifying antirheumatic drugs (DMARDs) and very low doses of oral glucocorticoids. One hundred and...
journal_title：Clinical rheumatology
pub_type： 临床试验,杂志文章
doi：10.1007/s10067-006-0462-4
更新日期：2007-07-01 00:00:00
abstract：:Systemic sclerosis (SSc) is an autoimmune disease which may lead to malnutrition. Previous studies have defined it with different criteria. No thorough evaluations of sarcopenia in SSc are available. The aim of the present study was to assess the prevalence and the potential association of malnutrition and sarcopenia ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3932-y
更新日期：2018-04-01 00:00:00
abstract：:Sarcoidosis is a multisystemic disease with cutaneous lesions present in about one fourth of patients. Cutaneous lesions may be specific or nonspecific based on the presence or the absence of sarcoidal granulomas. Subcutaneos sarcoidosis is the less frequent of the specific cutaneous lesions of sarcoidosis. We report ...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-011-1731-4
更新日期：2011-08-01 00:00:00
abstract：:Up to now, there is no uniformly accepted treatment for avascular necrosis (AN) that alleviates pain and retards its progression. The aim of clinical and surgical treatments is usually only to improve blood support in the avascular area. The objective of the present study was to make a systematic review of the use of ...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-008-0861-9
更新日期：2008-06-01 00:00:00
abstract：:Heart rate variability (HRV) gives information about sympathetic parasympathetic autonomic balance. Our purpose was to determine whether HRV is abnormal in patients with Sjögren's syndrome. In 16 patients with Sjögren's syndrome and 30 matched controls, a short time analysis of HRV was performed for both the frequency...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/pl00011180
更新日期：2000-01-01 00:00:00
abstract：OBJECTIVES:To evaluate sexual function in Tunisian women with rheumatoid arthritis (RA) and to compare it with that in voluntary healthy controls. METHODS:We conducted a cross-sectional study including 71 women with a confirmed diagnosis of RA according to the American College of Rheumatology/European League Against R...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-019-04726-8
更新日期：2019-12-01 00:00:00
abstract：:Cytokine gene loci are one of the potential susceptibility factors in immuno-inflammatory diseases. Interleukin1 (IL-1) is a major monocyte derived proinflammatory cytokine that mediates tissue damage and cartilage loss in chronic arthritis. IL-1 locus has been linked to various autoimmune diseases, but data on juveni...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-011-1898-8
更新日期：2012-04-01 00:00:00
abstract：:Caeruloplasmin (Cp), prealbumin and alpha 2-macroglobulin (alpha 2-M) concentrations in serum were compared in rheumatoid arthritis (RA), osteoarthrosis, ankylosing spondylitis, psoriatic arthritis, Reiter's syndrome, Behçet's syndrome, SLE and normal controls. Cp was significantly elevated (p less than 0.01) in all d...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02201003
更新日期：1987-03-01 00:00:00
abstract：:The study aimed to determine the serum level of glucocorticoid-induced tumor necrosis factor receptor family-related protein ligand (GITRL) in patients with rheumatoid arthritis (RA) and investigate its clinical significance. GITRL levels were measured by enzyme-linked immunosorbent assay (ELISA) in 88 RA patients, 20...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-016-3280-3
更新日期：2016-09-01 00:00:00
abstract：:Anaesthesia in patients with either treated or untreated osteo-articular disorders poses a number of specific problems. The authors deal with risks resulting from mechanical deformities produced by these disorders, by the involvement of a large number of functional systems, by changes in the immune status of such pati...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/BF02032315
更新日期：1985-03-01 00:00:00
abstract：:Although the Health Assessment Questionnaire (HAQ) and the Modified Health Assessment Questionnaire are useful tools for assessing and monitoring patients with rheumatic diseases, they have a "floor effect" and do not fully reflect the psychological status of patients. Recently, the Multidimensional Health Assessment ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-005-0049-5
更新日期：2006-05-01 00:00:00
abstract：:The antigens of HLA-DR locus were determined in 127 patients with rheumatoid arthritis and in 175 healthy persons. The frequency of HLA-DR1 antigen was discovered in 45% of the patients and in 22.3% of the examinees from the control group (p less than 0.001). The relative risk is 2.84. 69% of the patients were seropos...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/BF02030241
更新日期：1990-03-01 00:00:00
abstract：:Disease-modifying antirheumatic biological and non-biological therapies are associated with reduced disease progression and joint destruction. Suggestions have been made that total knee and hip joint arthroplasty indications are decreasing as a beneficial effect of the new forms of therapy for rheumatoid arthritis. We...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-010-1629-6
更新日期：2011-04-01 00:00:00
abstract：OBJECTIVE:Gout is a common inflammatory disease, and the prevalence of gout in men is significantly higher than in women. Catechol-O-methyltransferase (COMT) regulates dopamine activity and metabolism, thereby participating in the uric acid metabolism, which in turn affects the occurrence of gout. Our study aimed to in...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-019-04607-0
更新日期：2019-10-01 00:00:00
abstract：:A number of laboratory variables, including Hb., ESR and several phase proteins, fluctuated in concord with the clinical signs of synovitis activity in patients with rheumatoid arthritis during a controlled study of 3 disease-modifying anti-rheumatic drugs (DMARD). The correlation between laboratory variables and clin...
journal_title：Clinical rheumatology
pub_type： 临床试验,杂志文章
doi：10.1007/BF02201028
更新日期：1987-06-01 00:00:00
abstract：:Systemic lupus erythematosus (SLE) is a multi-system chronic inflammatory disease with a broad spectrum of clinical and serological manifestations. Although clinical evidence of proximal skeletal muscle involvement is not rare in patients with SLE, there is no knowledge about the effects of SLE on the macroscopic stru...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-013-2249-8
更新日期：2013-08-01 00:00:00
abstract：INTRODUCTION/OBJECTIVES:To determine the prevalence and factors associated with medication noncompliance by Thai patients with rheumatoid arthritis (RA). METHODS:This prospective cohort study enrolled 443 adult RA patients (≥ 18 years) who were followed up at the outpatient rheumatology clinics of Siriraj Hospital and...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05409-5
更新日期：2020-09-21 00:00:00
abstract：OBJECTIVES:To establish the prevalence of the associated secondary diseases in patients with Raynaud's phenomenon (RP) attending a rheumatology specialty centre and to determine the frequency with which a secondary illness develops in those having RP, in absence of a well-defined secondary cause. METHODS:118 consecuti...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-003-0726-1
更新日期：2003-10-01 00:00:00
abstract：:The lactogenic hormone prolactin is produced in part by cells of the immune system and serves as an upregulator of immune function. Hyperprolactinemia is common in patients with systemic lupus erythematosus (SLE), raising the possibility that the hormone contributes to the excessive immune response in the disease. The...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-005-0117-x
更新日期：2006-07-01 00:00:00
abstract：:Psoriatic arthritis (PsA) patients are often treated by dermatology and rheumatology specialities and may receive different treatments. To evaluate the impact of dermatology/rheumatology specialist settings on diagnosis and therapeutic approach in PsA patients. This cross-sectional multicounty study in Italy involved ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05482-w
更新日期：2020-11-06 00:00:00
abstract：:The aim of this study was to investigate whether calcium pyrophosphate dihydrate (CPPD) crystals are constantly detectable in sequential synovial fluid (SF) examinations of patients with initially CPPD-positive osteoarthritis (OA). For this purpose, we searched our SF database for CPPD-positive patients, who had two o...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-012-2147-5
更新日期：2013-05-01 00:00:00
abstract：:Hepatitis B virus (HBV) reactivation is a common complication of immunosuppressive treatment in high prevalence countries. Biological disease-modifying antirheumatic drugs (bDMARDs) cause this adverse event more often than conventional immunosuppressants. The incidence of HBV reactivation during treatment for rheumati...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-018-4295-8
更新日期：2018-11-01 00:00:00
abstract：OBJECTIVES:This study aimed to investigate the relationship among smoking, TNF-α-blocker therapy, and the dynamic changes in gut microbiota in patients with ankylosing spondylitis (AS). METHODS:Using a 16S rRNA sequence, 98 fecal samples of 20 AS patients collected after 0, 1, 3 and 6 months of anti-TNF-α treatment an...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05032-4
更新日期：2020-09-01 00:00:00
abstract：:The clinical response to traditional disease-modifying anti-rheumatic drugs (DMARDs) in indigent South Africans with early rheumatoid arthritis was investigated. A cohort of patients with early (≤2 years) RA who were DMARD-naïve at inception were prospectively assessed for response to DMARDs using the Simplified Disea...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-011-1900-5
更新日期：2012-04-01 00:00:00
abstract：:The aim of this study was to determine the serum interleukin-18 (IL-18) levels in patients with systemic lupus erythematosus (SLE) and to assess their relationship with disease activity. Thirty-five patients with SLE and 35 age- and sex-matched controls were enrolled in this study. Paired serum samples were collected ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-004-0867-x
更新日期：2004-06-01 00:00:00
