Utilize lung ultrasound B-lines and KL-6 to monitor anti-MDA-5 antibody-positive clinically amyopathic dermatomyositis-associated interstitial lung disease: a case report and literature review.

Abstract:

:In the past decade, lung ultrasound (LUS) B-lines and serum Krebs von den Lungen-6 (KL-6) antigen have been recognized as biomarkers of the connective tissue disease-associated interstitial lung diseases (CTD-ILDs). Robust data have demonstrated that B-lines total numbers and KL-6 levels are correlated with high-resolution computed tomography findings, pulmonary function test, and some clinical parameters in CTD-ILDs. However, limited data are available regarding the use of these two biomarkers to follow CTD-ILDs. Herein, we report a case with anti-melanoma differentiation-associated gene 5 antibody-positive clinically amyopathic dermatomyositis-associated ILD, successfully treated with high-dose methylprednisolone, cyclophosphamide, intravenous immunoglobulin, pirfenidone, and followed using lung ultrasound and KL-6.

journal_name

Clin Rheumatol

journal_title

Clinical rheumatology

authors

Wang Y,Chen S,Lin Z,Lin J,Xie X,Lin Q,Du G,Huang X,Matucci-Cerinic M,Furst DE

doi

10.1007/s10067-019-04462-z

subject

Has Abstract

pub_date

2019-05-01 00:00:00

pages

1433-1436

issue

5

eissn

0770-3198

issn

1434-9949

pii

10.1007/s10067-019-04462-z

journal_volume

38

pub_type

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