Cellular localization of the Ro/SS-A antigen.

Abstract:

:The cellular localization of the Ro/SS-A antigen was defined using indirect immunofluorescence and eight monospecific anti- Ro/SS-A antisera which were identified by immunoblotting. Several mammalian tissues were used as substrates. The Ro/SS-A antigen was located mainly in the nucleus of dog liver and Hep-2-cells, and anti-Ro sera had produced a speckled staining pattern. Cytoplasmic fluorescence appeared only in one serum. IgG was the predominant immunoglobulin with anti-Ro/SS-A activity; five sera had complement fixing activity. The sera absorption studies with partially purified Ro/SS-A antigen and the negativation of the ANA tests had confirmed the specificity of our findings.

journal_name

Clin Rheumatol

journal_title

Clinical rheumatology

authors

Lopez-Robles E,Herrera-Esparza R,Avalos-Diaz E

doi

10.1007/BF02030965

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

33-8

issue

1

eissn

0770-3198

issn

1434-9949

journal_volume

5

pub_type

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