Abstract：
:The aim of this study was to determine the serum interleukin-18 (IL-18) levels in patients with systemic lupus erythematosus (SLE) and to assess their relationship with disease activity. Thirty-five patients with SLE and 35 age- and sex-matched controls were enrolled in this study. Paired serum samples were collected from all the patients with SLE, both at active stage before treatment and at the stable stage after treatment. The serum IL-18 levels were determined using ELISA and their correlations with the disease activity, measured using the SLE Disease Activity Index (SLEDAI) and laboratory parameters such as anti-dsDNA antibody, CH50, C3, C4, and circulating immune complex levels, were analyzed. The serum IL-18 levels in patients with SLE were significantly higher than those in the controls, particularly when the disease status was active (mean+/-SD: active stage, 721.23+/-360.15 pg/ml; inactive stage, 343.68+/-317.78 pg/ml; controls, 113.98+/-13.22 pg/ml, p<0.05). The IL-18 levels measured at the active stage before treatment correlated well with SLEDAI (r=0.41, p<0.05) and anti-dsDNA antibody titer (r=0.35, p<0.05). When we compared the changes of the IL-18 level and those of parameters reflecting the disease activity between the active stage and the stable stage of the disease, it was found that the changes in IL-18 level correlated well with the changes of SLEDAI score during the patient's disease course (r=0.39, p<0.05). In conclusion, the serum IL-18 levels were elevated in patients with SLE, and these increased levels correlated well with SLE disease activity.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Park MC,Park YB,Lee SKdoi
10.1007/s10067-004-0867-xsubject
Has Abstractpub_date
2004-06-01 00:00:00pages
225-9issue
3eissn
0770-3198issn
1434-9949journal_volume
23pub_type
杂志文章abstract：:The antichromatin antibody (aCT) has been described as a useful marker for lupus nephropathy. The relevance of its nephritogenic potential may be appropriately evaluated in the context of renal histopathology. Therefore, the present study investigated the relationship of aCT with a particular histopathologic class of ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-008-0939-4
更新日期：2008-11-01 00:00:00
abstract：:Clinical guidelines regarding anti-viral prophylaxis for HBV surface antigen (HBsAg) carriers starting anti-TNFα agents are not yet fully established, even in endemic regions of HBV infection. We retrospectively collected the clinical data of 52 HBsAg carriers with rheumatoid arthritis (RA) or ankylosing spondylitis (...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-012-1960-1
更新日期：2012-06-01 00:00:00
abstract：:Seventy-nine patients suffering from rheumatoid factor positive rheumatoid arthritis (RA) were included in this study. In each patient disease activity was assessed three times at two-week intervals during a four-week period. All factors that might possibly influence RA, except atmospheric conditions (AC) were held co...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02206665
更新日期：1991-12-01 00:00:00
abstract：:A patient presenting with interstitial lung disease was predicted to have underlying polymyositis when found to be anti-Jo-1 antibody positive. When myopathy developed later with elevated serum creatine phosphokinase and myoglobin levels, the electromyogram was nonmyopathic, and polymyositis was confirmed by muscle bi...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02201038
更新日期：1987-06-01 00:00:00
abstract：OBJECTIVE:Antineutrophil cytoplasmic antibodies (ANCAs) are considered a risk factor for granulomatosis with polyangiitis (GPA) exacerbation, especially when staphylococcal superantigens (SAgs) are present in nasal swabs. Their role in monitoring disease activity remains controversial. This study determined the relatio...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-019-04693-0
更新日期：2019-11-01 00:00:00
abstract：:Bone metabolism in patients with rheumatoid arthritis is reviewed. Two different entities are recognised: 1) a localised periarticular bone loss, due to inflammatory processes and 2) a generalised increased bone turnover, ultimately leading to a loss of axial bone mass. The mechanism of this loss of axial bone is not ...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/BF02284051
更新日期：1988-03-01 00:00:00
abstract：OBJECTIVE:To test the efficacy of Infliximab, a chimeric monoclonal antibody against TNF-alpha, in the treatment of Takayasu arteritis. MATERIALS AND METHODS:We used infliximab at an initial dose of 3 mg/kg i.v. at weeks 0, 2, 6, and 8 thereafter in combination with methotrexate or azathioprine, to treat four patients...
journal_title：Clinical rheumatology
pub_type： 临床试验,杂志文章
doi：10.1007/s10067-006-0227-0
更新日期：2007-06-01 00:00:00
abstract：:The aim of this study was to analyse microvascular damage and compensatory angiogenesis in skin from patients with systemic sclerosis (SSc) compared with systemic lupus erythematosus (SLE), Raynaud's phenomenon (RP) and healthy controls. Immunohistochemistry was used for skin biopsies (9 SSc, 10 SLE, 9 RP and 12 healt...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-003-0698-1
更新日期：2003-09-01 00:00:00
abstract：:Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a wide range of manifestations and potential to affect several organ systems. Complications arise from both disease and medications especially glucocorticoids, significantly contributing to overall morbidity and mortality. SLE predominantly affect...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-019-04795-9
更新日期：2020-03-01 00:00:00
abstract：:The objective of the study is to determine the risk factors for the development of reactive arthritis (ReA) and examine the factors associated with the persistence of symptoms. Patients with a new diagnosis of ReA and controls with a gastrointestinal (GI), urogenital, or sexually transmitted infection in the 3-6 month...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3911-3
更新日期：2018-02-01 00:00:00
abstract：:Leptin is known to play an important role in the pathophysiology of osteoarthritis (OA). This study investigated whether synovial fluid (SF) leptin level is related to the radiographic severity of OA and its role as a quantitative marker for the detection of OA. SF was obtained from 42 OA patients who underwent knee s...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-009-1242-8
更新日期：2009-12-01 00:00:00
abstract：OBJECTIVES:(1) Development and validation of a composite ultrasound score (cUSS) for the diagnosis of carpal tunnel syndrome (CTS). (2) To predict treatment response after local corticosteroid injection. METHODS:Wrists of CTS patients and controls were evaluated with high-resolution ultrasound and cross-sectional area...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05228-8
更新日期：2020-07-21 00:00:00
abstract：BACKGROUND:Clustering of autoimmune diseases is common and may be due to genetic background and exposition to environmental triggers. OBJECTIVE:The aim is to carry out a laboratory and clinical study of the prevalence of gastrointestinal organ-specific autoantibodies in rheumatoid arthritis (RA) patients and their rel...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-010-1540-1
更新日期：2011-01-01 00:00:00
abstract：:In the last 5 years, several hundred articles have been published concerning the link between primary immunodeficiency disease (PID) and rheumatologic diseases. Although rheumatologic complications were originally thought to be at the opposite ends of the spectrum of immunopathologic manifestations, they are now all b...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-016-3229-6
更新日期：2016-04-01 00:00:00
abstract：:The aim of this study was to assess the diagnostic value of the Psoriatic Arthritis Screening Evaluation (PASE) and Early Psoriatic Arthritis Screening Questionnaire (EARP) questionnaires in the ultrasonographic detection of enthesitis, synovitis, and tenosynovitis. A cross-sectional study was done in a total of 96 co...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-016-3392-9
更新日期：2016-10-01 00:00:00
abstract：:The autoantibody profiles in New Zealand systemic sclerosis patients have not previously been reported. The aim of this study was to evaluate the autoantibody profiles of patients in the Waikato Hospital Systemic Sclerosis Clinic cohort. The EUROLINE (IgG) Systemic Sclerosis panel test kit (which tests for Scl-70, CEN...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-015-2981-3
更新日期：2015-11-01 00:00:00
abstract：:This study aims to evaluate the impact of arthritis on the physical function of people living in a Maya-Yucateco rural community and to assess the association of known modifiable risk factors with the prevalence of overall arthritis and its main types (osteoarthritis and rheumatoid arthritis). Using a cross-sectional,...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-015-3084-x
更新日期：2016-07-01 00:00:00
abstract：:Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease causing joint damage and significant functional impairment. Methotrexate (MTX) remains the mainstay for the treatment of RA. MTX inhibits several enzymes of the folate and nucleotide pathways. Thymidylate synthase (TYMS) is an important enzyme in the d...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3608-7
更新日期：2017-06-01 00:00:00
abstract：OBJECTIVES:The invalidation or social pain is an important but neglected issue in polysymptomatology of fibromyalgia (FM). This study sought whether tracing-perceived invalidation could be effective to discriminate between the presence and absence of FM in chronic pain patients with respect to five different sources, i...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05515-4
更新日期：2021-01-07 00:00:00
abstract：:It has been well established that, anti-thyroglobulin antibodies (ATG) and anti-microsomal antibodies (AMC) may be present in various thyroid disorders and other systemic autoimmune diseases, including Sjögren's syndrome (SS). However, presence of circulating autoantibodies to thyroid hormones, i.e. both to triiodothy...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s100670170102
更新日期：2001-01-01 00:00:00
abstract：INTRODUCTION:Studies conducted by various scientific societies have shown that the demand for specialized rheumatology care is greater than the projected growth of the workforce. Our research aims to assess the current status of the rheumatology workforce in Latin America. METHOD:This is a descriptive, cross-sectional...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05555-w
更新日期：2021-01-15 00:00:00
abstract：:Susceptibility to systemic lupus erythematosus (SLE) is associated with genetic, hormonal, immunological, and environmental factors. Many genes have been related with the appearance of SLE, including several loci that code different complement components and their receptors. Some genetic deficiencies of complement mol...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-008-0838-8
更新日期：2008-04-01 00:00:00
abstract：:Adult-onset Still's disease (AOSD) is an autoimmune disease characterized by spiking fever, evanescent rash, arthritis, serositis, and liver involvement. Although autoimmune hepatitis (AIH) has been reported in association with various autoimmune diseases, AOSD-associated AIH is rare. We herein report an unusual case ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-009-1186-z
更新日期：2010-01-01 00:00:00
abstract：:The use of biotechnology-derived medicines has significantly increased in recent decades. Although biosimilars undergo rigorous characterization as well as clinical studies to document their safety and effectiveness, they are highly complex molecules and small changes in the purification and production process of a bi...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-015-2887-0
更新日期：2015-04-01 00:00:00
abstract：:The aim of the study was to investigate the long-term outcome of non-specific seronegative oligoarthritis in adults. The study included 64 adult patients with recent (<6 months) seronegative oligoarthritis (rheumatoid factor negative, number of swollen joints 1-4 during the first 6 months). Follow-up examinations were...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s100670200096
更新日期：2002-09-01 00:00:00
abstract：:Central nervous involvement (CNS) is uncommon manifestation of Wegener's granulomatosis (WG). We are describing a patient with refractory WG with CNS involvement which responded to rituximab. This lady presented with nodular scleritis. Three months later, she developed headache, vision loss with complete opthalmoplegi...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-009-1291-z
更新日期：2010-01-01 00:00:00
abstract：UNLABELLED:There is a paucity of data on the impact of chronic rheumatic diseases on functional disability and overall health-related quality of life (HRQOL) in Africans. MATERIALS AND METHODS:We compared Black South Africans (BSA) with rheumatoid arthritis (RA) (n=50) and systemic lupus erythematosus (SLE) (n=50) to ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-006-0215-4
更新日期：2007-01-01 00:00:00
abstract：:rs2431697 is located on 5q33.3, between pituitary tumor-transforming gene 1 and miR-146a. Several studies have estimated the association between rs2431697 and systemic lupus erythematosus risk. However, the results were inconsistent. A case-control study was carried out to explore the association between rs2431697 and...
journal_title：Clinical rheumatology
pub_type： 杂志文章,meta分析
doi：10.1007/s10067-015-3045-4
更新日期：2015-11-01 00:00:00
abstract：:Two cases of Paget's sarcoma of bone are described. The first one is mainly characterized by the almost simultaneous degeneration of the only two existing locations of the underlying Paget's disease. The second case is one of monostotic Paget's disease of the scapula disclosed by the malignant degeneration. ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02031268
更新日期：1984-12-01 00:00:00
abstract：:While fibromyalgia is frequently associated with ear-related symptoms such as feeling of ear fullness, earache, and tinnitus, the pathogenesis of these ear-related symptoms in fibromyalgia patients is unknown. Here, we focused on clarifying the pathogenesis of ear fullness, a particularly common symptom observed in fi...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-013-2287-2
更新日期：2013-10-01 00:00:00
