Abstract：
:Rheumatoid arthritis (RA) is well known to affect many different organ systems. Previous work suggests that this includes the auditory system and that measures of hearing may be related to indices of RA disease activity. The aims of this study were to determine whether hearing loss in young subjects with rheumatoid arthritis is greater than would be expected in the normal population and whether disease activity or duration correlate with hearing levels. About 55 patients (less than 50 years old) with RA were sampled from a secondary-care-level population. Pure-tone audiograms, transient evoked otoacoustic emissions (TEOAEs) and rheumatological assessment including disease duration and the DAS28 disease activity score were carried out. Subjective hearing loss was a common symptom with a prevalence of 29.6% (95% CI 17.8-42.2%). The prevalence of conductive hearing loss was 1.9% (95% CI 0.3-9.7%)). Subjects with RA had worse hearing than expected at low and middle frequencies (250 Hz to 2 kHz). TEOAEs were absent in 15 of 84 (18%, 95% CI 11-27%) normal ears. No relationship was demonstrated between hearing thresholds and markers of disease activity or other rheumatological parameters. Hearing loss is common in young people with RA and should be sought by clinicians caring for this patient population. TEOAEs are absent in a higher proportion of patients than expected, and this may be a marker of early asymptomatic hearing loss. It may be conductive or sensorineural and may take any configuration, including low-frequency loss.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Murdin L,Patel S,Walmsley J,Yeoh LHdoi
10.1007/s10067-007-0802-zsubject
Has Abstractpub_date
2008-05-01 00:00:00pages
637-40issue
5eissn
0770-3198issn
1434-9949journal_volume
27pub_type
杂志文章abstract：BACKGROUND:In antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), central nervous system (CNS) involvement is relatively uncommon. The current study retrospectively investigated the clinical features and outcomes of AAV patients with CNS involvement. METHODS:A total of 497 AAV patients were retrosp...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-04975-y
更新日期：2020-07-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
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pub_type： 杂志文章,meta分析
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更新日期：2020-05-01 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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更新日期：2015-11-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2008-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2018-08-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章,多中心研究
doi：10.1007/s10067-019-04431-6
更新日期：2019-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2008-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s10067-007-0741-8
更新日期：2008-05-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
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更新日期：2016-12-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
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更新日期：2008-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s100670050106
更新日期：1999-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：1996-03-01 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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journal_title：Clinical rheumatology
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1993-06-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
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更新日期：1998-01-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 临床试验,杂志文章
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更新日期：1998-01-01 00:00:00
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pub_type： 杂志文章,已发布勘误
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更新日期：2018-09-01 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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更新日期：1986-06-01 00:00:00
