Infliximab in Takayasu arteritis: a safe alternative?

Abstract:

OBJECTIVE:To test the efficacy of Infliximab, a chimeric monoclonal antibody against TNF-alpha, in the treatment of Takayasu arteritis. MATERIALS AND METHODS:We used infliximab at an initial dose of 3 mg/kg i.v. at weeks 0, 2, 6, and 8 thereafter in combination with methotrexate or azathioprine, to treat four patients with Takayasu arteritis. RESULTS:Three out of four patients responded to infliximab treatment, while two of them retained the response during a two-year follow up. A higher dose regimen (5 mg/kg), however, was eventually warranted for two of the responders. No major side effects were noted. CONCLUSIONS:Infliximab might be an effective and safe alternative for patients with Takayasu arteritis.

journal_name

Clin Rheumatol

journal_title

Clinical rheumatology

authors

Karageorgaki ZT,Mavragani CP,Papathanasiou MA,Skopouli FN

doi

10.1007/s10067-006-0227-0

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

984-7

issue

6

eissn

0770-3198

issn

1434-9949

journal_volume

26

pub_type

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