Abstract：
:Anti-nucleosome antibodies, which recognise conformational epitopes consisting of histone and DNA in chromatin, have been described in autoimmune diseases. In this study, an attempt was made to isolate anti-nucleosome antibodies from the anti-DNA-depleted plasma IgG of two lupus patients either with or without nephritis by nucleohistone affinity chromatography. The purified nucleohistone-binding antibodies bound to nucleohistone in a specific manner and contained enriched anti-histone antibodies. However, adsorption of the purified antibodies with histone revealed that the nephritis patient-derived antibodies contained nucleohistone-specific antibodies. Although such purified antibodies may not recognise native structures of nucleosomes, this chromatography may provide a method to isolate and determine the fine specificity of anti-nucleosome antibodies in various autoimmune diseases.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Suenaga R,Mitamura K,Abdou NIdoi
10.1007/BF01451045subject
Has Abstractpub_date
1998-01-01 00:00:00pages
189-94issue
3eissn
0770-3198issn
1434-9949journal_volume
17pub_type
临床试验,杂志文章abstract：:The effect of long-term (18-70 months) chloroquine treatment 250 mg daily, in rheumatoid arthritis (RA) was studied in 20 patients. Sedimentation rates were significantly reduced, as compared to a reference group of 10 RA patients on no treatment of disease modifying anti-rheumatic drugs. Radiographical progression of...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02041561
更新日期：1983-12-01 00:00:00
abstract：:This study aimed to compare the intraobserver and interobserver reliability of three-dimensional (3D) and two-dimensional (2D) power Doppler ultrasonography (PDUS) and to assess the relationship between 3D PDUS and clinical parameters in patients with rheumatoid arthritis (RA). Bilateral second/third metacarpophalange...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-011-1811-5
更新日期：2012-02-01 00:00:00
abstract：:We report the case of a woman who developed chorea in her neck, trunk, and extremities soon after taking gabapentin as treatment for complex regional pain syndrome Type 1. The chorea lasted for a year and resolved completely within 2 weeks of discontinuing gabapentin. ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-007-0744-5
更新日期：2008-03-01 00:00:00
abstract：:There are few reports about the coexistence of Sjögren's syndrome (SS) and ankylosing spondylitis (AS). To evaluate the frequency of SS in patients with AS. We studied 70 patients with AS presenting to the university outpatient clinic between January 2002 and November 2003. All the patients were asked about sicca symp...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-006-0255-9
更新日期：2007-02-01 00:00:00
abstract：:We investigated the clinical characteristics, management modalities, and outcomes in patients with relapsing polychondritis (RP) with airway involvement. The medical records of RP patients with airway involvement seen at Samsung Medical Center from August 2004 to December 2011 were collected. The clinical manifestatio...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-013-2279-2
更新日期：2013-09-01 00:00:00
abstract：:Current Canadian osteoporosis guidelines recommend routine bone density screening of men at age 65. The purpose of this study is to determine the prevalence of osteoporosis in men aged 65-75 in after application of screening guidelines. All males aged 65-75 years who attended a large primary care clinic were advised o...
journal_title：Clinical rheumatology
pub_type： 杂志文章,多中心研究
doi：10.1007/s10067-014-2642-y
更新日期：2015-03-01 00:00:00
abstract：:Rheumatic diseases do not usually cluster in time and space. It has been proposed that environmental exposures may initiate autoimmune responses. We describe a cluster of rheumatic diseases among a group of health center employees who began to complain of symptoms typically related to moldy houses, including mucocutan...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-003-0753-y
更新日期：2003-12-01 00:00:00
abstract：:The aim of this research was to determine any correlations between Dickkopf-1 serum levels (Dkk-1, a natural inhibitor of the Wnt signaling pathway promoting osteoclastogenesis) and the Trabecular Bone Score (TBS), in systemic sclerosis (SSc) and rheumatoid arthritis (RA) patients. It also aimed at determining any dif...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-018-4322-9
更新日期：2018-11-01 00:00:00
abstract：:Oxidative stress was related with carpal tunnel syndrome (CTS). We aimed to clarify the associations between glutathione S-transferase (GST)M1, GSTT1 and GSTP1-Ile105Val polymorphisms and CTS. One hundred-forty patients with CTS and 97 healthy controls were enrolled in this study. Tinel and Phalen signs were noted as ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-014-2855-0
更新日期：2016-05-01 00:00:00
abstract：:Autoinflammatory disorders (AIDs) are a novel class of diseases elicited by mutations in genes regulating the homeostasis of innate immune complexes, named inflammasomes, which lead to uncontrolled oversecretion of the proinflammatory cytokine interleukin-1β. Protean inflammatory symptoms are variably associated with ...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-014-2721-0
更新日期：2015-01-01 00:00:00
abstract：:We encountered an adult patient with acute parvovirus B19 infection who presented with transient lupus-like symptoms (i.e., polyarthritis, fever, myalgia, pancytopenia, hypocomplementemia, and nephritis). Our case is characterized by the demonstration of acute nephritis as a complication of this infection, making it d...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-007-0691-1
更新日期：2008-01-01 00:00:00
abstract：:Takayasu's arteritis (TA) is a rare vasculitis that affects the aorta and its primary branches. Heterogeneous clinical manifestations have been described in different geographical areas. We aimed to evaluate demographic, clinical, and angiographic features and the outcome in 16 TA patients who were followed in a singl...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-008-1009-7
更新日期：2009-02-01 00:00:00
abstract：:Pauci-immune necrotizing glomerulonephritis is a form of a rapidly progressive glomerulonephritis that is associated with the anti-neutrophil cytoplasmic antibodies (ANCA). ANCA-associated pauci-immune glomerulonephritis may be secondary to rheumatic diseases. We report on a patient with limited cutaneous systemic scl...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-012-2010-8
更新日期：2012-08-01 00:00:00
abstract：:Muscle pain and weakness in a rheumatoid arthritis (RA) patient has a broad differential, and myositis should be considered early in the disease course as serious limb and life-threatening sequelae may occur. A 55-year-old woman with a past medical history of methotrexate-controlled RA presented with right leg pain fo...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-014-2657-4
更新日期：2015-10-01 00:00:00
abstract：:This study aimed to compare the diagnostic value of ultrasonography to conventional radiography in detecting osteophytes and erosions in the midfoot joints in patients suffering from inflammatory and non-inflammatory joint disease. Patients with current foot radiographs were included and stratified in two cohorts: inf...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3658-x
更新日期：2017-09-01 00:00:00
abstract：:The objective of this study was to identify predictors for remission or low disease activity (LDA) in established rheumatoid arthritis (RA) at 12 months of anti-TNF-α therapy. We have performed a prospective observational study in 90 consecutive patients with active RA receiving TNF-α inhibitors. Baseline and standard...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-012-2146-6
更新日期：2013-05-01 00:00:00
abstract：:The aim of this study was to investigate the association of two common interleukin 12B (IL-12B) polymorphisms (rs3212227 and rs6887695) with rheumatoid arthritis (RA) susceptibility through meta-analyses. A systematic literature search of PubMed, Web of Science, Cochrane Library, and Embase databases was conducted on ...
journal_title：Clinical rheumatology
pub_type： 杂志文章,meta分析
doi：10.1007/s10067-016-3327-5
更新日期：2017-02-01 00:00:00
abstract：:Pain is a leading cause of morbidity worldwide, with published data showing its prevalence as high as 50% for chronic pain in the European population. This prevalence is likely to continue to rise, particularly in elderly people with comorbid conditions and complex aetiologies of pain. There is thus a rapidly growing ...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-006-0311-5
更新日期：2006-01-01 00:00:00
abstract：:The Osteoporosis Assessment Questionnaire Short Version (OPAQ-SV) was cross-culturally adapted to measure health-related quality of life in Chinese osteoporotic fracture females and then validated in China for its psychometric properties. Cross-cultural adaptation, including translation of the original OPAQ-SV into Ma...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-015-3010-2
更新日期：2016-04-01 00:00:00
abstract：:The high concentrations of pro-inflammatory prostaglandins (PGs) produced in the joint during the initial stage of inflammation can be decreased by inhibiting their biosynthesis with nonsteroidal anti-inflammatory drugs (NSAIDs). The commonly encountered gastrointestinal intolerance in human subjects treated with NSAI...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02214106
更新日期：1989-03-01 00:00:00
abstract：:A case of polymyositis associated with scleroderma, adult coeliac disease, diabetes mellitus and IgA nephropathy is reported in a 33-year-old male. ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02031278
更新日期：1984-12-01 00:00:00
abstract：:A patient fulfilling the diagnostic criteria for systemic lupus erythematosus and presenting with catatonic schizophrenia is described. Psychiatric features of the disease and their management are discussed. ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02031619
更新日期：1985-09-01 00:00:00
abstract：:Microwave thermography is the technique of measuring natural thermal radiation from body tissues of clinical interest. It is safe, requires no control of environmental conditions and exposes the patient to no ionising radiation. In this study, we found that microwave thermography of the knee joints showed weak correla...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02242999
更新日期：1994-12-01 00:00:00
abstract：BACKGROUND:The early detection of psoriatic arthritis (PSA) poses a challenge to rheumatologists, even when their diagnosis is aided by sonography. In order to facilitate early detection of PSA among patients with psoriasis (PSO), we retrospectively analyzed of the relationships between serological markers and comorbid...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05132-1
更新日期：2020-12-01 00:00:00
abstract：:Biologic therapies have brought improved efficacy in the field of rheumatoid arthritis (RA), but their use in clinical practice may be limited by concerns over cost. Predictive models are, therefore, needed to identify those people with RA with the worst potential outcomes, who will benefit most from the use of these ...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-010-1639-4
更新日期：2011-03-01 00:00:00
abstract：:Matrix metalloproteinases (MMPs) are the key enzymes responsible for the joint destruction. Their activity is regulated by the level of proinflammatory cytokines. The aim of this study was to examine the impact of TNF-α G-308A polymorphism on MMP-9 levels in blood plasma (BP) and synovial fluid (SF) of patients with r...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3699-1
更新日期：2017-07-01 00:00:00
abstract：:Acute phase proteins, synovial fluid (SF) cellular infiltrates, pro-inflammatory (TNF-alpha, IL-1alpha, IL-6) and Th1 (IL-2) and Th2 (IL-4) derived cytokine levels both in plasma and SF were examined in pauciarticular and polyarticular juvenile chronic arthritis (JCA) patients during the active (n = 22) and inactive (...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF01451007
更新日期：1998-01-01 00:00:00
abstract：:A 22-year-old African male with known sickle cell anaemia was referred by a Congolese medical centre with a request to improve his poor physical condition. He was unable to walk, stand or sit because his large joints and his spine were either ankylosed or very rigid. Radiographs showed joint fusion from the third to t...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s100670070047
更新日期：2000-01-01 00:00:00
abstract：PURPOSE:To explore the 18F-fluoro-dexoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) imaging characteristics of adult-onset Still's disease (AOSD) and its significance in differential diagnosis from other connective tissue diseases (CTDs). METHODS:FDG PET/CT images of 54 patients with AOSD...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05041-3
更新日期：2020-09-01 00:00:00
abstract：:A cohort of patients with recently diagnosed axial spondyloarthritis (SpA) was characterized with emphasis on gender differences and factors leading to delay in diagnosis. Clinical, laboratory, and imaging data of 151 consecutive patients diagnosed with ankylosing spondylitis or undifferentiated SpA in 2004-2009 and s...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-011-1719-0
更新日期：2011-08-01 00:00:00
