Abstract:
:Tissue plasminogen activator (tPA), plasminogen activator inhibitor-1 (PAI-1) and von Willebrand factor (vWF), all of endothelial origin and active in the haemostasis, were analysed in 74 patients with rheumatoid arthritis. The concentrations were related to extra-articular disease and to the incidence of thromboembolic events (TE) registered in a 2-year follow-up period. Patients with extra-articular disease had a significant increase in PAI-1 activity and reduced tPA release in the venous occlusion test. von Willebrand factor, PAI-1 and also haptoglobin and triglycerides were significantly increased in the group of patients who later suffered from TE. In a multiple regression model, in which cholesterol, triglycerides and lipoprotein (a) showed significant association with TE, vWF had the strongest additive explanatory value. No distinct acute phase pattern of PAI-1 was found in any patient subgroup.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Wållberg-Jonsson S,Dahlén GH,Nilsson TK,Rånby M,Rantapää-Dahlqvist Sdoi
10.1007/BF02231572subject
Has Abstractpub_date
1993-09-01 00:00:00pages
318-24issue
3eissn
0770-3198issn
1434-9949journal_volume
12pub_type
杂志文章abstract::Chorea is a rare complication of systemic lupus erythematosus (SLE) and is strongly related to the presence of antiphospholipid antibodies. Various infections may also be triggering factors in the development of choreiform movements. Additionally, Salmonella infection is the most common opportunistic bacterial infecti...
journal_title:Clinical rheumatology
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02249023
更新日期:1994-06-01 00:00:00
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pub_type: 杂志文章
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02054251
更新日期:1986-09-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2009-05-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
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更新日期:2021-01-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-003-0769-3
更新日期:2004-02-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
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journal_title:Clinical rheumatology
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更新日期:2016-03-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
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journal_title:Clinical rheumatology
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更新日期:1984-12-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
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更新日期:2017-06-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-008-1074-y
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