Tissue plasminogen activator, plasminogen activator inhibitor-1 and von Willebrand factor in rheumatoid arthritis.

Abstract:

:Tissue plasminogen activator (tPA), plasminogen activator inhibitor-1 (PAI-1) and von Willebrand factor (vWF), all of endothelial origin and active in the haemostasis, were analysed in 74 patients with rheumatoid arthritis. The concentrations were related to extra-articular disease and to the incidence of thromboembolic events (TE) registered in a 2-year follow-up period. Patients with extra-articular disease had a significant increase in PAI-1 activity and reduced tPA release in the venous occlusion test. von Willebrand factor, PAI-1 and also haptoglobin and triglycerides were significantly increased in the group of patients who later suffered from TE. In a multiple regression model, in which cholesterol, triglycerides and lipoprotein (a) showed significant association with TE, vWF had the strongest additive explanatory value. No distinct acute phase pattern of PAI-1 was found in any patient subgroup.

journal_name

Clin Rheumatol

journal_title

Clinical rheumatology

authors

Wållberg-Jonsson S,Dahlén GH,Nilsson TK,Rånby M,Rantapää-Dahlqvist S

doi

10.1007/BF02231572

subject

Has Abstract

pub_date

1993-09-01 00:00:00

pages

318-24

issue

3

eissn

0770-3198

issn

1434-9949

journal_volume

12

pub_type

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