Abstract：
:The current treatment for antiphospholipid syndrome (APS) with thrombotic manifestation is long-term anticoagulation. Vitamin K antagonists (VKA) are usually the agents of choice. However, VKA limitations, such as unpredictable anticoagulation effects due to interaction with diet and other drugs, require regular monitoring. This may impact on patients' quality of life. Since the approval of new oral anticoagulants (NOAC) for non-valvular atrial fibrillation and deep vein thrombosis prevention, much has been speculated about its use in APS patients. We report here a series of eight APS patients with failure of thrombotic prevention during rivaroxaban use. All patients had venous thrombosis as the initial manifestation of APS, and two of them also had arterial manifestations. Three patients had triple antibody positivity. Five patients developed arterial events during the treatment with rivaroxaban. Until the results of ongoing trials of rivaroxaban for APS are presented, NOAC should not be recommended to APS patients. Our preliminary experience as well cases previously reported in the literature suggest that there is a high-risk group that is less protected with rivaroxaban, namely those with previous arterial thrombosis or triple positivity. VKA remains to be the mainstay treatment for thrombotic APS.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Signorelli F,Nogueira F,Domingues V,Mariz HA,Levy RAdoi
10.1007/s10067-015-3030-ysubject
Has Abstractpub_date
2016-03-01 00:00:00pages
801-5issue
3eissn
0770-3198issn
1434-9949pii
10.1007/s10067-015-3030-yjournal_volume
35pub_type
杂志文章abstract：:Wegener's granulomatosis (WG) is a systemic granulomatous vasculitis that typically affects the upper airways, lungs and kidneys. Lymphadenopathy is rare in patients with WG. Here, we present the first case of WG whose initial manifestation was superficial lymphadenopathy (i.e. supraclavicular and axillary lymphadenop...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s100670200128
更新日期：2002-11-01 00:00:00
abstract：:The aim of this study was to evaluate the safety and efficacy of azathioprine in the treatment of interstitial lung disease (ILD) associated with systemic sclerosis (SSc). The records of patients with SSc with ILD who were treated with azathioprine were reviewed. Patients were treated with azathioprine and low-dose pr...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-004-0906-7
更新日期：2004-08-01 00:00:00
abstract：:The aims of this study were to determine whether placebo treatment in randomised controlled trials (RCTs) is effective for fibromyalgia and to identify possible determinants of the magnitude of any such placebo effect. A systematic literature search was undertaken for RCTs in people with fibromyalgia that included a p...
journal_title：Clinical rheumatology
pub_type： 杂志文章,meta分析
doi：10.1007/s10067-017-3595-8
更新日期：2017-07-01 00:00:00
abstract：:Ultrasound elastography (UE) is a new ultrasound-based imaging technique that provides information about elasticity and stiffness of tissues. This cross-sectional study aimed to identify the diagnostic importance of UE in supraspinatus impingement syndrome. Forty-one subjects, aged 38-70 years, were included in the st...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3928-7
更新日期：2018-06-01 00:00:00
abstract：:Microwave thermography is the technique of measuring natural thermal radiation from body tissues of clinical interest. It is safe, requires no control of environmental conditions and exposes the patient to no ionising radiation. In this study, we found that microwave thermography of the knee joints showed weak correla...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02242999
更新日期：1994-12-01 00:00:00
abstract：:Sixty-one Thai patients with ankylosing spondylitis (AS), diagnosed in accordance with Rome and New York criteria for AS, were studied. The cases includes idiopathic AS (46 cases), Reiter's syndrome AS (8 cases) and psoriatic spondylitis (7 cases). The vast majority of patients were male (Male:Female = 11.2:1), and in...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02032322
更新日期：1985-03-01 00:00:00
abstract：:The autoantibody profiles in New Zealand systemic sclerosis patients have not previously been reported. The aim of this study was to evaluate the autoantibody profiles of patients in the Waikato Hospital Systemic Sclerosis Clinic cohort. The EUROLINE (IgG) Systemic Sclerosis panel test kit (which tests for Scl-70, CEN...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-015-2981-3
更新日期：2015-11-01 00:00:00
abstract：BACKGROUND:Sarcoidosis is a chronic inflammatory disease characterized by non-caseating granuloma which etiology is unknown yet. Adipokines are different proteins synthesized by adipose tissue that have an influence on angiogenesis, hemostasis, lipid metabolism, and immune system regulation. Adipokines may play a role ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-04980-1
更新日期：2020-07-01 00:00:00
abstract：:Melorheostosis is a very rare bone disease of unknown etiology characterised by linear hyperostosis and associated with fibrosis of soft tissues and the skin. This uncommon sclerosing bone dysplasia was first described by Leri and Joanny in 1922, and since then, until 1993, approximately 300 cases were reported in the...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF01451298
更新日期：1998-01-01 00:00:00
abstract：:Multilevel studies have gained importance for highlighting social inequalities in health. These associations have been reported previously in diseases such as arthritis and chronic pain. We conducted a cross-sectional study using multilevel analysis to identify individual and contextual factors associated with the var...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-014-2776-y
更新日期：2016-01-01 00:00:00
abstract：:The objective of this study was to identify predictors for remission or low disease activity (LDA) in established rheumatoid arthritis (RA) at 12 months of anti-TNF-α therapy. We have performed a prospective observational study in 90 consecutive patients with active RA receiving TNF-α inhibitors. Baseline and standard...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-012-2146-6
更新日期：2013-05-01 00:00:00
abstract：:We report one case of non-Hodgkin lymphoma in a patient, with a 30-year history of rheumatoid arthritis, taking low dose methotrexate weekly over a 10-month period. The mild immunosuppression that occurs with methotrexate therapy probably places patients with rheumatoid arthritis at added risk of developing lymphoprol...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02231567
更新日期：1993-03-01 00:00:00
abstract：:The aim of this study was to evaluate if pulsed electromagnetic field therapy (PEMF) has additional effect on the classical physical treatment of knee osteoarthritis (OA) composed of hot pack, therapeutic ultrasound, and terminal isometric exercises. Forty patients (29 women and 11 men), ages 44 to 78 (mean age was 61...
journal_title：Clinical rheumatology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10067-010-1453-z
更新日期：2010-08-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:ABP 798 is a proposed biosimilar to the originator biologic rituximab, an anti-CD20 monoclonal antibody. This comparative clinical study evaluated the pharmacokinetics (PK), safety, and efficacy of ABP 798 versus rituximab reference product (RP) in patients with moderate-to-severe rheumatoid arthr...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05305-y
更新日期：2020-11-01 00:00:00
abstract：:The aim of our study was to explore the relationship between circulating T cells and ankylosing spondylitis (AS) and to find the role of the CD8+CD122+ T cells in the pathogenesis and progression of AS. With the method of case-control design, flow cytometry was performed to quantitatively determine the percentage of c...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3887-z
更新日期：2018-03-01 00:00:00
abstract：:Iron-binding proteins (lactoferrin, transferrin and ferritin) and free iron were measured in synovial fluid (SF) from 30 patients with rheumatoid arthritis (RA) and 20 osteoarthritis (OA) patients. The iron-binding proteins except transferrin were significantly increased in RA SF as compared with OA SF. Similarly, fre...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02030347
更新日期：1989-09-01 00:00:00
abstract：:Small differences in inbred animals with a gene for arthritis must be the cause that some of them evolve the disease and others not. These differences are partly stochastic, caused by thermal movement of molecules. It is possible that their effect is amplified by a network of cytokines, known to play an important role...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF03342643
更新日期：1996-01-01 00:00:00
abstract：:In addition to juxtaarticular osteoporosis, which appears to reflect predominantly local disease mechanisms, more generalized bone loss can occur in rheumatoid arthritis (RA). The aim of this study was to compare bone mineral density (BMD) of the lumbar spine and proximal femur in RA patients versus controls and evalu...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02207677
更新日期：1995-07-01 00:00:00
abstract：:Patients with osteoporosis often have chronic kidney disease (CKD). CKD is associated with bone and mineral disturbances, renal osteodystrophy, which like osteoporosis leads to a higher risk of fractures. Bisphosphonates are first-line therapy for osteoporosis; however, these are contra-indicated in patients with a GF...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-015-2883-4
更新日期：2015-08-01 00:00:00
abstract：:Information about the distribution of effusion within the arthritic knee joint should be considered in selecting an anatomical approach for arthrocentesis. We recorded ultrasound measurements of fluid distribution in the knees of patients attending our clinic for knee injections under ultrasound guidance. In a cross-s...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-012-1987-3
更新日期：2012-08-01 00:00:00
abstract：:In an open study, we have assessed the bone/soft tissue uptake index in recent osteoporotic vertebral collapse using scintigraphy. The evolution of these cases was followed-up at 6 months in 22 patients treated with 100 IU of salmon calcitonin plus 500 mg of elemental calcium/10 days per month and in 18 patients treat...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02208694
更新日期：1991-09-01 00:00:00
abstract：OBJECTIVES:In people with rheumatoid arthritis (RA), mental health problems are common, but often not recognized or treated, contributing to increased morbidity and mortality. Most studies examining the impact of mental health problems in RA have focused on depression. We aimed to determine the association between anxi...
journal_title：Clinical rheumatology
pub_type： 杂志文章,meta分析
doi：10.1007/s10067-019-04900-y
更新日期：2020-05-01 00:00:00
abstract：:Heterogenous population of cells, including macrophages, synoviocytes and lymphocytes play important roles in the immunopathogenesis of rheumatoid arthritis (RA). T cells, however, seem to be a common thread throughout the disease process. In inhibiting T lymphocytes, cyclosporin A presents a more selective form of th...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/BF02215854
更新日期：1995-09-01 00:00:00
abstract：:The aims of this study were to find the characteristics and prevalence of nailfold capillary changes in a large series of patients with Behçet's disease (BD) and to analyze their possible relation to other clinical characteristics of the disease. We performed nailfold capillaroscopy in 128 randomly selected patients f...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-009-1106-2
更新日期：2009-05-01 00:00:00
abstract：:IL-34 is a pleiotropic cytokine, which is a key regulator of monocytes/macrophages and might participate in the pathogenesis of RA. In this study, we aimed to explore the effect of IL-34 on the monocyte-like cell line THP-1 and the quantitative variation of Th17 cells in THP-1 and RA CD4+T cells coculture system. CD4+...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3746-y
更新日期：2018-01-01 00:00:00
abstract：:This article is a small case series that aims to discuss the impact of depression, vascular, and fibrotic changes on development of erectile dysfunction (ED) in patients with systemic sclerosis (SSc). In this paper, we present five male patients with SSc, aged 30-48 years. All patients are nonsmokers, and their past m...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-007-0567-4
更新日期：2007-10-01 00:00:00
abstract：:Anaesthesia in patients with either treated or untreated osteo-articular disorders poses a number of specific problems. The authors deal with risks resulting from mechanical deformities produced by these disorders, by the involvement of a large number of functional systems, by changes in the immune status of such pati...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/BF02032315
更新日期：1985-03-01 00:00:00
abstract：:Systemic sclerosis (SSc) is an autoimmune disease which may lead to malnutrition. Previous studies have defined it with different criteria. No thorough evaluations of sarcopenia in SSc are available. The aim of the present study was to assess the prevalence and the potential association of malnutrition and sarcopenia ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3932-y
更新日期：2018-04-01 00:00:00
abstract：OBJECTIVE:To test the efficacy of Infliximab, a chimeric monoclonal antibody against TNF-alpha, in the treatment of Takayasu arteritis. MATERIALS AND METHODS:We used infliximab at an initial dose of 3 mg/kg i.v. at weeks 0, 2, 6, and 8 thereafter in combination with methotrexate or azathioprine, to treat four patients...
journal_title：Clinical rheumatology
pub_type： 临床试验,杂志文章
doi：10.1007/s10067-006-0227-0
更新日期：2007-06-01 00:00:00
abstract：:Familial Mediterranean fever (FMF) is an autoinflammatory disorder. It is caused by mutations in the MEFV gene encoding the pyrin protein, which regulates the innate inflammatory response. The aim of the current study was to investigate the relationship between serum Interleukin-4 (IL-4) and its gene polymorphism, nam...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-018-4214-z
更新日期：2018-12-01 00:00:00
