Experience with azathioprine in systemic sclerosis associated with interstitial lung disease.

Abstract:

:The aim of this study was to evaluate the safety and efficacy of azathioprine in the treatment of interstitial lung disease (ILD) associated with systemic sclerosis (SSc). The records of patients with SSc with ILD who were treated with azathioprine were reviewed. Patients were treated with azathioprine and low-dose prednisone if they had progressive pulmonary symptoms (deterioration in the dyspnea score) or poor or deteriorating lung function. Response was classified as improved if the FVC increased more than 10% from baseline, and stable if it remained within 10% of baseline. Serial dyspnea scores were recorded. Eleven patients were treated with azathioprine, three of whom received treatment for 6 months or less owing to adverse effects (nausea, leukopenia and pulmonary tuberculosis in one patient each). The remaining eight patients received at least 12 months' treatment and the results suggested an improvement in the mean percent predicted FVC from a baseline value of 54.25+/-3.53 to 63.38+/-6.15 after 12 months ( p=0.101). Overall, five patients improved and three remained stable. The mean dyspnea score ( n=8) improved from a baseline of 1.55+/-0.19 to 0.50+/-0.19 at 12 months ( p=0.011). This is the first case series of patients with SSc-associated ILD treated with azathioprine. Our results suggest that azathioprine may have a role in stabilizing lung function and improving symptoms in SSc, although this needs confirmation by a randomized controlled trial.

journal_name

Clin Rheumatol

journal_title

Clinical rheumatology

authors

Dheda K,Lalloo UG,Cassim B,Mody GM

doi

10.1007/s10067-004-0906-7

subject

Has Abstract

pub_date

2004-08-01 00:00:00

pages

306-9

issue

4

eissn

0770-3198

issn

1434-9949

journal_volume

23

pub_type

杂志文章
  • Association of interferon regulatory factor 5 (IRF5) gene polymorphisms with juvenile idiopathic arthritis.

    abstract::Interferon regulatory factor 5 (IRF5) is a member of IRF family which induce signaling pathways and are involved in modulation of cell growth, differentiation, apoptosis, and immune system activity. Juvenile idiopathic arthritis (JIA) is an auto-inflammatory syndrome where the inflammatory markers are believed to play...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-018-4010-9

    authors: Esmaeili Reykande S,Rezaei A,Sadr M,Shabani M,Najmi Varzaneh F,Ziaee V,Rezaei N

    更新日期:2018-10-01 00:00:00

  • Inflammation and shoulder pain--a perspective on rotator cuff disease, adhesive capsulitis, and osteoarthritis: conservative treatment.

    abstract::Shoulder pain may occur as a secondary symptom to a wide range of conditions, including rotator cuff disorders, glenohumeral osteoarthritis, or adhesive capsulitis. One common factor linking these diseases is inflammation. Understanding the role of inflammation in shoulder disorders can help physicians to manage and t...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,收录出版,评审

    doi:10.1007/s10067-009-1109-z

    authors: Saccomanni B

    更新日期:2009-05-01 00:00:00

  • High expression levels of microRNA-629, microRNA-525-5p and microRNA-516a-3p in paediatric systemic lupus erythematosus.

    abstract::Paediatric systemic lupus erythematosus (pSLE) refers to childhood-onset systemic lupus erythematosus. pSLE has its own unique characteristics, and its pathogenesis is unclear. To study the relationship between microRNAs (miRNAs) and pSLE, we selected three pSLE patients who were newly diagnosed and had not yet been t...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-014-2583-5

    authors: Zhu J,Huang X,Su G,Wang L,Wu F,Zhang T,Song G

    更新日期:2014-06-01 00:00:00

  • Post-partum sacral fracture associated with heparin treatment.

    abstract::We report the case of a 19-year-old woman who consulted for low-back pain 3 weeks after her first delivery. This young woman had a personal history of protein C deficiency and was treated daily during her pregnancy with low-molecular-weight heparin. Her body mass index was 34 and she only gained 10 kg during her pregn...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-008-0898-9

    authors: Goëb V,Strotz V,Verdet M,Le Loët X,Vittecoq O

    更新日期:2008-12-01 00:00:00

  • Severe gastrointestinal involvement in systemic sclerosis.

    abstract::Gastrointestinal tract (GIT) is the most common organ system involved in systemic sclerosis (SSc). GIT involvement is mainly attributed to GIT dismobility and wide mouth diverticular. GIT involvement in SSc can be also severely debilitating and even life threatening. To our knowledge, the presence of gastrointestinal ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-006-0264-8

    authors: Plastiras SC,Tzivras M,Vlachoyiannopoulos PG

    更新日期:2007-06-01 00:00:00

  • Chagas disease reactivation in rheumatologic patients: association with immunosuppressive therapy and humoral response.

    abstract::Evidence for Chagas disease reactivation (CDR) in rheumatologic patients under rheumatologic treatments (RTs) is scarce. To screen and follow-up patients with rheumatic diseases and concomitant Chagas disease under RT to detect CDR and to describe a possible relationship between CDR and specific RT. An observational, ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-021-05581-2

    authors: Ringer A,Ruffino JP,Leiva R,Cuadranti N,Argento MC,Martínez MF,Rolla I,Chulibert S,Carbone D,Palatnik M,Cortese MN,Lagrutta M,Córdoba L,González FB,Pacini MF,Villar SR,Águila D,Bottasso OA,Pérez AR,Abdala M

    更新日期:2021-01-12 00:00:00

  • Cardiovascular risk stratification and appropriate use of statins in patients with systemic lupus erythematosus according to different strategies.

    abstract:INTRODUCTION/OBJECTIVES:Cardiovascular risk management of patients with systemic lupus erythematosus (SLE) is medically relevant. The objectives were to estimate the cardiovascular risk by different strategies in patients with SLE, analyzing which proportion of patients would be candidates to receive statin therapy, an...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-019-04856-z

    authors: Masson W,Rossi E,Mora-Crespo LM,Cornejo-Peña G,Pessio C,Gago M,Alvarado RN,Scolnik M

    更新日期:2020-02-01 00:00:00

  • Smoking and Behçet's disease.

    abstract::It has recently been claimed that some of the symptoms in patients with Behçet's disease (BD) can be activated after the patient has stopped smoking. In this study we investigated the effect of smoking on the symptoms of Behçet's disease. Fifty asymptomatic current smokers (CS) who promised to stop smoking (group 1) a...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s100670070020

    authors: Soy M,Erken E,Konca K,Ozbek S

    更新日期:2000-01-01 00:00:00

  • Knee joint destruction driven by residual local symptoms after anti-tumor necrosis factor therapy in rheumatoid arthritis.

    abstract::In patients with rheumatoid arthritis who had symptomatic knee joints at the start of anti-tumor necrosis factor (TNF) therapy, the relationship between local symptoms and knee joint destruction at 94 weeks was retrospectively investigated. Among the patients with rheumatoid arthritis and received anti-TNF therapy, th...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-013-2181-y

    authors: Imagama T,Tanaka H,Tokushige A,Seki K,Sumiura S,Yamamoto M,Nagahiro Y,Taguchi T

    更新日期:2013-06-01 00:00:00

  • From scleredema to AL amyloidosis: disease progression or coincidence? Review of the literature.

    abstract::Scleredema (also called scleredema of Buschke) is a fibromucinous connective tissue disorder of unknown cause that belongs to a group of scleroderma-like disorders. We report the case of a 64-year-old lady with long-standing scleredema, associated with a paraprotein, and progressing to multiple myeloma and AL amyloido...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/s10067-004-1076-3

    authors: Dziadzio M,Anastassiades CP,Hawkins PN,Potter M,Gabrielli A,Brough GM,Black CM,Denton CP

    更新日期:2006-02-01 00:00:00

  • Isolation of anti-nucleosome antibodies from the plasma of lupus nephritis patients.

    abstract::Anti-nucleosome antibodies, which recognise conformational epitopes consisting of histone and DNA in chromatin, have been described in autoimmune diseases. In this study, an attempt was made to isolate anti-nucleosome antibodies from the anti-DNA-depleted plasma IgG of two lupus patients either with or without nephrit...

    journal_title:Clinical rheumatology

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF01451045

    authors: Suenaga R,Mitamura K,Abdou NI

    更新日期:1998-01-01 00:00:00

  • Unusual long bone and metacarpo-carpal abnormalities in a case of pseudo-pseudohypoparathyroidism.

    abstract::A case of pseudo-pseudohypoparathyroidism (PPH) with shortening of the left femur and tibia and coalition of the base of the fourth metacarpals with capitatum and hamatum in bilateral wrist joints was presented. Involvement of the fourth digits both in hands and feet were more prominent on the left side, with shorteni...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-006-0279-1

    authors: Unlu Z,Orguc S,Yilmaz Ovali G,Bayindir P

    更新日期:2007-07-01 00:00:00

  • Noninvasive methods of bone-mass measurement.

    abstract::The most widely used noninvasive methods of bone mass measurement include: single photon absorptiometry (SPA), quantitative computed tomography (QCT), dual photon absorptiometry (DPA and DEXA). SPA is used to measure bone mineral content (BMC) of the distal radius. Its advantages are low cost and high precision in viv...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/BF02207232

    authors: Sabatier JP,Guaydier-Souquieres G

    更新日期:1989-06-01 00:00:00

  • Urine macrophage migration inhibitory factor in pediatric systemic lupus erythematosus.

    abstract::We reported a series of ten patients with lupus nephritis (five patients in the relapse phase and five in the remission phase) and measured the macrophage migration inhibitory factor (MIF), an important pro-inflammatory cytokine with probable role in the pathogenesis of many inflammatory diseases, in their urine sampl...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-007-0632-z

    authors: Otukesh H,Chalian M,Hoseini R,Chalian H,Hooman N,Bedayat A,Yazdi RS,Sabaghi S,Mahdavi S

    更新日期:2007-12-01 00:00:00

  • Lung magnetic resonance imaging in systemic sclerosis: a new promising approach to evaluate pulmonary involvement and progression.

    abstract:INTRODUCTION/OBJECTIVES:Interstitial lung disease (ILD) is frequent and highly disabling in systemic sclerosis (SSc). Magnetic resonance imaging (MRI) is not routinely used to evaluate the lung, due to poorer spatial resolution compared to high-resolution computed tomography (HRCT). We aimed to compare lung MRI signal ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-020-05491-9

    authors: Gargani L,Bruni C,De Marchi D,Romei C,Guiducci S,Bellando-Randone S,Aquaro GD,Pepe A,Neri E,Colagrande S,Falaschi F,Moggi-Pignone A,Pingitore A,Matucci-Cerinic M

    更新日期:2020-11-07 00:00:00

  • Predictors of activity limitation in people with gout: a prospective study.

    abstract::The objective of the study was to determine clinical factors associated with activity limitation and predictors of a change in activity limitation after 1 year in people with gout. Two hundred ninety-five participants with gout (disease duration < 10 years) attended a baseline assessment which included medical and dis...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-018-4110-6

    authors: Stewart S,Rome K,Eason A,House ME,Horne A,Doyle AJ,Knight J,Taylor WJ,Dalbeth N

    更新日期:2018-08-01 00:00:00

  • Cost of medication errors in rheumatic patients in Mexico.

    abstract::This study aims to measure the frequency of medication error (ME) in rheumatology outpatients of the Social Security System (SS) in Mexico and to measure the costs by comparing the days lost at work as direct consequence of the medication error against the theoretical cost of no error in the process. A prospective 6-m...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-011-1837-8

    authors: Aceves-Avila FJ,Benites-Godínez V,Ramos-Remus C

    更新日期:2011-11-01 00:00:00

  • Fear of movement and avoidance behaviour toward physical activity in chronic-fatigue syndrome and fibromyalgia: state of the art and implications for clinical practice.

    abstract::Severe exacerbation of symptoms following physical activity is characteristic for chronic-fatigue syndrome (CFS) and fibromyalgia (FM). These exacerbations make it understandable for people with CFS and FM to develop fear of performing body movement or physical activity and consequently avoidance behaviour toward phys...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/s10067-013-2277-4

    authors: Nijs J,Roussel N,Van Oosterwijck J,De Kooning M,Ickmans K,Struyf F,Meeus M,Lundberg M

    更新日期:2013-08-01 00:00:00

  • Polymyositis complicating donor lymphocyte infusion after stem cell transplantation for relapsed chronic myeloid leukemia: report of a case and review of literature.

    abstract::Polymyositis may occur along with other manifestations of chronic graft vs host disease after allogeneic bone marrow transplantation (BMT). Donor lymphocyte infusion (DLI) could produce durable remissions in relapsed patients with chronic myelogenous leukemia (CML) but it may contribute to the development of polymyosi...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-006-0346-7

    authors: Liu FC,Chen CH,Chao TY

    更新日期:2007-07-01 00:00:00

  • IL1 gene polymorphisms in enthesitis related arthritis category of juvenile idiopathic arthritis (ERA-JIA).

    abstract::Cytokine gene loci are one of the potential susceptibility factors in immuno-inflammatory diseases. Interleukin1 (IL-1) is a major monocyte derived proinflammatory cytokine that mediates tissue damage and cartilage loss in chronic arthritis. IL-1 locus has been linked to various autoimmune diseases, but data on juveni...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-011-1898-8

    authors: Aggarwal A,Srivastava R,Singh S,Kumar Dubey P

    更新日期:2012-04-01 00:00:00

  • Normal serum concentrations of 1,25 dihydroxyvitamin D in osteoporosis.

    abstract::With the aim of evaluating the role of 1,25 dihydroxyvitamin D in the pathogenesis of osteoporosis, this hormone was studied in 90 subjects. They were divided into three groups: the first group consisted of 30 normal female subjects (aged 30 to 45); the second group comprised 30 elderly female subjects (aged 67 to 90)...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02031970

    authors: Cantatore FP,Carrozzo M

    更新日期:1990-06-01 00:00:00

  • Long-term efficacy and safety of interferon α-2a therapy in severe refractory ophthalmic Behcet's disease.

    abstract::Ophthalmic involvement is the most debilitating complication of Behcet's disease (BD). The aim of the current study is to report on the efficacy and safety of a long-term use of interferon alpha-2a (IFNα-2a) in the treatment of refractory ophthalmic BD in the Azari population of Iran. We retrospectively analyzed the c...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-016-3318-6

    authors: Kavandi H,Khabbazi A,Kolahi S,Hajialilo M,Shayan FK,Oliaei M

    更新日期:2016-11-01 00:00:00

  • Colonic transit disorders in systemic sclerosis.

    abstract::Systemic sclerosis (SS) alters smooth muscle function throughout the gastrointestinal tract, the oesophagus being the segment most often involved. Involvement of the colon, though less common, may lead to life-threatening complications. We studied 23 unselected patients with SS and 20 age-matched healthy controls usin...

    journal_title:Clinical rheumatology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s100670170038

    authors: Wang SJ,Lan JL,Chen DY,Chen YH,Hsieh TY,Lin WY

    更新日期:2001-01-01 00:00:00

  • Antineutrophil cytoplasmic antibodies in juvenile chronic arthritis.

    abstract::We present the results of antineutrophil cytoplasmic antibody (ANCA) staining in patients with juvenile chronic arthritis (JCA). Thirty-one patients with an age range of 1-16 years were included in the study: 13, 15 and three patients, respectively, were classified having oligoarticular, polyarticular and systemic-ons...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s100670050106

    authors: Bakkaloglu A,Ozen S,Saatci U,Erguven S,Topaloglu R,Bassoy Y,Besbas N

    更新日期:1999-01-01 00:00:00

  • Behçet's disease in Lebanon: clinical profile, severity and two-decade comparison.

    abstract::The aim of this study is to describe the clinical features of Lebanese patients with Behçet's disease (BD) followed up at a tertiary care center in Lebanon. A retrospective review of medical records of 90 patients who fulfilled the International Study Group (ISG) criteria for diagnosis was performed. The clinical char...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-005-0058-4

    authors: Hamdan A,Mansour W,Uthman I,Masri AF,Nasr F,Arayssi T

    更新日期:2006-05-01 00:00:00

  • Growth disturbances in experimental juvenile arthritis of the dog knee.

    abstract::In the study of pathophysiological mechanisms in growth abnormalities of the juvenile knee in arthritis an animal model in dogs was developed. Arthritis was induced by intra-articular injections of Carrageenan. Prominent growth changes were enlargement of the distal femoral epiphysis, patellar squaring and decreased e...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02030752

    authors: Bunger C,Bunger EH,Harving S,Djurhuus JC,Jensen OM

    更新日期:1984-06-01 00:00:00

  • Tumour necrosis factor alpha and interleukin-2 in plasma from rheumatoid arthritis patients in relation to disease activity.

    abstract::Tumour necrosis factor alpha (TNF alpha) and interleukin-2 (IL-2) are potential immunological mediators of pathogenetic changes in rheumatoid arthritis. We measured the concentrations of TNF alpha and IL-2 in plasma from 2 groups of patients suffering from rheumatoid arthritis (RA). One group had high and one had low ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02206655

    authors: Espersen GT,Vestergaard M,Ernst E,Grunnet N

    更新日期:1991-12-01 00:00:00

  • Frailty and reduced physical function go hand in hand in adults with rheumatoid arthritis: a US observational cohort study.

    abstract::Reduced physical function and health-related quality of life are common in rheumatoid arthritis (RA), and further studies are needed that examine novel determinates of reduced physical function in RA. This study examines whether frailty, a state of increased vulnerability to stressors, is associated with differences i...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s10067-017-3541-9

    authors: Andrews JS,Trupin L,Yelin EH,Hough CL,Covinsky KE,Katz PP

    更新日期:2017-05-01 00:00:00

  • Increased IL-6 expression on THP-1 by IL-34 stimulation up-regulated rheumatoid arthritis Th17 cells.

    abstract::IL-34 is a pleiotropic cytokine, which is a key regulator of monocytes/macrophages and might participate in the pathogenesis of RA. In this study, we aimed to explore the effect of IL-34 on the monocyte-like cell line THP-1 and the quantitative variation of Th17 cells in THP-1 and RA CD4+T cells coculture system. CD4+...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-017-3746-y

    authors: Wang B,Tang Y,Sun X,Ouyang X,Li H,Wei J,Zhang Y,Li X

    更新日期:2018-01-01 00:00:00

  • A case report of tumor necrosis factor-alpha antibody-induced thrombocytopenia associated with emerging IgM anticardiolipin antibody in patients with scleroderma overlap/rheumatoid arthritis.

    abstract::It is commonly believed that infliximab-induced anticardiolipin antibody belongs to the IgM subclass but not the IgG subclass and that the IgM subclass could not produce clinical symptoms. However, we had a patient with scleroderma overlap/rheumatoid arthritis who developed thrombocytopenia associated with the appeara...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-006-0229-y

    authors: Hamaguchi M,Kawahito Y,Ishino H,Yoshida M,Yoshikawa T

    更新日期:2007-06-01 00:00:00