Abstract：
:The aim of this blinded, randomised, multicentre study was to compare the tolerability of aspirin, paracetamol and ibuprofen in common pain resulting from musculoskeletal conditions (MSC) in general practice with patients with other non-MSC pain conditions. Patients took aspirin, paracetamol (both up to 3g daily) or ibuprofen (up to 1.2g daily) for up to 7 days. The main outcome was the rate of significant adverse events (SGAE). Four thousand two hundred and ninety one patients with MSC were evaluable (1436 aspirin, 1423 paracetamol, 1432 ibuprofen) and 4101 (95.5%) were per-protocol. A group of 4342 patients included for other (non-MSC) mild to moderate pain conditions was used for comparison. In the MSC group, SGAE were reported by 20.5% of patients with aspirin, 17.0% with paracetamol and 15.0% with ibuprofen. Ibuprofen was statistically equivalent to paracetamol and better tolerated than aspirin (p <0.0001). Ibuprofen was associated with fewer digestive system AE (4.4%) than aspirin (8.6%, p<0.0001) and paracetamol (6.5%, p <0.02). The non-MSC group showed similar intertreatment differences, but experienced fewer SGAE. No serious digestive events were observed with any of the three treatments in either group. These results show that in patients with mild to moderate pain resulting from MSC, ibuprofen given in OTC doses for 6 days is as well tolerated as paracetamol and better tolerated than aspirin.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Le Parc JM,Van Ganse E,Moore N,Wall R,Schneid H,Verrière Fdoi
10.1007/s100670200007subject
Has Abstractpub_date
2002-02-01 00:00:00pages
28-31issue
1eissn
0770-3198issn
1434-9949journal_volume
21pub_type
临床试验,杂志文章,随机对照试验abstract：:Joint lavage for knee osteoarthritis is an invasive procedure that can be stressful and painful. We aimed to assess the impact of music therapy on perioperative anxiety, pain and tolerability of the procedure in patients undergoing joint lavage performed with two needles. We randomized all patients diagnosed with knee...
journal_title：Clinical rheumatology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10067-011-1925-9
更新日期：2012-03-01 00:00:00
abstract：:A possible role of tumor necrosis factor alpha (TNFalpha) in the pathomechanism of sarcoidosis must be considered in the analysis of this disorder since elevated concentrations of this cytokine have been found. In addition, TNFalpha expression could be demonstrated in sarcoid granulomata [1]. It is well known that TNF...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-005-0037-9
更新日期：2006-07-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-012-2052-y
更新日期：2012-11-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-005-0142-9
更新日期：2007-03-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-009-1291-z
更新日期：2010-01-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/BF03342632
更新日期：1995-07-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-013-2202-x
更新日期：2013-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s10067-016-3530-4
更新日期：2017-02-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2012-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2018-01-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-007-0691-1
更新日期：2008-01-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05555-w
更新日期：2021-01-15 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/pl00011198
更新日期：2001-01-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 临床试验,杂志文章
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更新日期：1984-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s10067-006-0356-5
更新日期：2007-08-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
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更新日期：2012-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s10067-020-05052-0
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pub_type： 杂志文章
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更新日期：2018-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2008-11-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
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更新日期：2007-11-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
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更新日期：2007-06-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章,收录出版,评审
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更新日期：2009-05-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章,已发布勘误
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更新日期：2018-09-01 00:00:00
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更新日期：2007-10-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
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更新日期：1991-06-01 00:00:00
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更新日期：2017-01-01 00:00:00
