Abstract:
:An understanding of the cytokine cascade in a rheumatoid joint has led to the development of new therapeutic options, including drugs targeting tumor necrosis factor-alpha (TNF-alpha). The safety profile of these agents in patients with hepatitis-induced liver disease, however, remains a concern because of risks associated with immune suppression. To examine the effect of three different TNF-alpha antagonists, infliximab, etanercept, and adalimumab, on serum transaminases and hepatitis viral load in patients with rheumatoid arthritis (RA) and concurrent hepatitis B (HBV) or hepatitis C (HCV). Medical records of 11 patients with diagnosis of RA and documented seropositivity for hepatitis B or hepatitis C were retrospectively reviewed for worsening of hepatic inflammation and viral proliferation as measured by a rise in aspartate aminotransferase (AST) or alanine aminotransferase (ALT) and viral load while using these agents. Three patients had RA with concurrent chronic HBV and eight patients had RA with concurrent chronic HCV. Seven patients remained on a single anti-TNF-alpha agent and four patients switched to a second anti-TNF-alpha agent due to treatment failure. Two patients showed a transient elevation in AST and/or ALT from normal, but in all 11 patients, AST and ALT levels were within one time the upper range of normal at the conclusion of the study. No significant increase in viral load was seen except one patient who showed a fourfold increase from baseline. Our case series supports results obtained from previous studies examining the safety of anti-TNF-alpha agents in patients with underlying hepatic disease. Use of these agents in patients with HBV or HCV may be associated with a transient transaminitis but appears to be safe overall. In both groups, frequent monitoring of serum transaminase levels and viral load is essential.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Li S,Kaur PP,Chan V,Berney Sdoi
10.1007/s10067-009-1149-4subject
Has Abstractpub_date
2009-07-01 00:00:00pages
787-91issue
7eissn
0770-3198issn
1434-9949journal_volume
28pub_type
杂志文章abstract::The pathogenesis of the idiopathic inflammatory myopathies has been postulated to be an environmental trigger causing the expression of the disease in a genetically predisposed patient. We report a case of anti-Jo1 antibody-positive myositis which was associated with pleural effusions, pericardial effusion with tampon...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-004-0890-y
更新日期:2004-08-01 00:00:00
abstract::Familial Mediterranean fever (FMF) is an autoinflammatory disorder. It is caused by mutations in the MEFV gene encoding the pyrin protein, which regulates the innate inflammatory response. The aim of the current study was to investigate the relationship between serum Interleukin-4 (IL-4) and its gene polymorphism, nam...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4214-z
更新日期:2018-12-01 00:00:00
abstract::The aim of this study was to describe how persons with rheumatoid arthritis (RA) of working age experience and handle their fatigue in everyday life. Six focus group discussions were conducted focusing on experiences of fatigue in 25 persons with RA (19 women, 6 men), aged 20-60 years. The discussions were recorded, t...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-012-2133-y
更新日期:2013-05-01 00:00:00
abstract::We report a case of bleomycin-induced scleroderma in a 35-year-old woman treated with chemotherapy for Hodgkin's disease. Approximately 6 months after the first chemotherapy cycle, the patient developed skin sclerosis in both arms. The lesion showed no signs of spontaneous clinical amelioration and treatment with ster...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670050131
更新日期:1999-01-01 00:00:00
abstract::Either total hip arthroplasty (THA), total knee arthroplasty (TKA) or both were performed in 105 patients from 1981 to 1994. These patients were experiencing severe joint destruction in the lower extremities due to rheumatoid arthritis (RA). These patients were followed for more than 2 years after their last operation...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF01452259
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVES:Rheumatoid arthritis (RA) may increase the risk of anxiety, but results from prior studies have no consensus. Our study aimed to evaluate the relationship between RA and incident anxiety by using a quantitative meta-analysis. METHODS:A number of databases were used to gather relevant information; they inclu...
journal_title:Clinical rheumatology
pub_type: 杂志文章,meta分析
doi:10.1007/s10067-019-04502-8
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Sarcoidosis is a chronic inflammatory disease characterized by non-caseating granuloma which etiology is unknown yet. Adipokines are different proteins synthesized by adipose tissue that have an influence on angiogenesis, hemostasis, lipid metabolism, and immune system regulation. Adipokines may play a role ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-04980-1
更新日期:2020-07-01 00:00:00
abstract::A variety of systemic autoimmune disorders have been reported in patients with myelodysplastic and myeloproliferative syndromes. A possible association with polymyalgia rheumatica and giant cell arteritis has also been recognised. We report another case of polymyalgia rheumatica and one of giant cell arteritis associa...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670200081
更新日期:2002-08-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-009-1333-6
更新日期:2010-03-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-015-2883-4
更新日期:2015-08-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3760-0
更新日期:2018-08-01 00:00:00
abstract::The aim of this study was to describe the abnormalities identified with conventional MRI in children with neuropsychiatric systemic lupus erythematosus (NPSLE). This was single-centre (Great Ormond Street Hospital, London) retrospective case series of patients with juvenile NPSLE seen in 2003-2013. Brain MR images of ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-016-3376-9
更新日期:2016-10-01 00:00:00
abstract::Severe exacerbation of symptoms following physical activity is characteristic for chronic-fatigue syndrome (CFS) and fibromyalgia (FM). These exacerbations make it understandable for people with CFS and FM to develop fear of performing body movement or physical activity and consequently avoidance behaviour toward phys...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-013-2277-4
更新日期:2013-08-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,已发布勘误
doi:10.1007/s10067-018-4280-2
更新日期:2018-10-01 00:00:00
abstract::The antigens of HLA-DR locus were determined in 127 patients with rheumatoid arthritis and in 175 healthy persons. The frequency of HLA-DR1 antigen was discovered in 45% of the patients and in 22.3% of the examinees from the control group (p less than 0.001). The relative risk is 2.84. 69% of the patients were seropos...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/BF02030241
更新日期:1990-03-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-012-2035-z
更新日期:2012-09-01 00:00:00
abstract::To identify clinical variables capable of predicting long-term treatment duration of TNF-α inhibition in patients with Behçet's disease (BD)-related uveitis. Demographic, clinical, and therapeutic data were retrospectively collected from BD patients treated with the tumor necrosis factor (TNF)-α blockers infliximab an...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4092-4
更新日期:2018-06-01 00:00:00
abstract::The aim of this study was to describe a single-center experience in the treatment and follow-up of cystoid macular edema patients. Clinical records of all patients with cystoid macular edema followed up in the Rheumatologic and Ophthalmological Unit of our center between 1993 and 2013 were retrospectively evaluated. T...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-014-2694-z
更新日期:2015-04-01 00:00:00
abstract::We compared the short-term effects of Stanger bath therapy and conventional exercises on spinal mobility, functional capacity, disease activity, and quality of life with conventional exercise alone in ankylosing spondylitis (AS) patients. A total of 58 patients with a diagnosis of AS according to the modified New York...
journal_title:Clinical rheumatology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10067-008-0873-5
更新日期:2008-07-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-003-0769-3
更新日期:2004-02-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/BF02032315
更新日期:1985-03-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-014-2517-2
更新日期:2014-04-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02231556
更新日期:1993-03-01 00:00:00
abstract::To evaluate the influence of TNF-α inhibitor on lipid profile and atherogenic index of plasma (AIP) in axial spondyloarthritis (axSpA) patients with long-term use of stable dose TNF-α inhibitor. AxSpA patients were enrolled in the Catholic Axial Spondyloarthritis COhort (CASCO). We collected their data annually and an...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-019-04767-z
更新日期:2020-02-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3590-0
更新日期:2017-05-01 00:00:00
abstract::It is commonly believed that infliximab-induced anticardiolipin antibody belongs to the IgM subclass but not the IgG subclass and that the IgM subclass could not produce clinical symptoms. However, we had a patient with scleroderma overlap/rheumatoid arthritis who developed thrombocytopenia associated with the appeara...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-006-0229-y
更新日期:2007-06-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-012-2010-8
更新日期:2012-08-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4289-6
更新日期:2018-11-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670200096
更新日期:2002-09-01 00:00:00
abstract::This study investigated the association of combined arthritis and diabetes, diabetes only, and arthritis only compared with neither with gait speed in the general population. This cross-sectional study included data from the second wave of Midlife in the United States-2 (MIDUS 2) project 4: Biomarker Project, 2004-200...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05370-3
更新日期:2020-08-27 00:00:00