Abstract：
:Low-dose naltrexone (LDN) has been demonstrated to reduce symptom severity in conditions such as fibromyalgia, Crohn's disease, multiple sclerosis, and complex regional pain syndrome. We review the evidence that LDN may operate as a novel anti-inflammatory agent in the central nervous system, via action on microglial cells. These effects may be unique to low dosages of naltrexone and appear to be entirely independent from naltrexone's better-known activity on opioid receptors. As a daily oral therapy, LDN is inexpensive and well-tolerated. Despite initial promise of efficacy, the use of LDN for chronic disorders is still highly experimental. Published trials have low sample sizes, and few replications have been performed. We cover the typical usage of LDN in clinical trials, caveats to using the medication, and recommendations for future research and clinical work. LDN may represent one of the first glial cell modulators to be used for the management of chronic pain disorders.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Younger J,Parkitny L,McLain Ddoi
10.1007/s10067-014-2517-2subject
Has Abstractpub_date
2014-04-01 00:00:00pages
451-9issue
4eissn
0770-3198issn
1434-9949journal_volume
33pub_type
杂志文章,评审abstract：:Back problems and back pain are amongst the most prevalent conditions afflicting Australians and carry high direct and indirect costs for the health care systems of all developed countries. A major gap in the research literature on this topic is the longitudinal analysis of health seeking behaviour for people with bac...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-009-1299-4
更新日期：2010-01-01 00:00:00
abstract：:Reduced physical function and health-related quality of life are common in rheumatoid arthritis (RA), and further studies are needed that examine novel determinates of reduced physical function in RA. This study examines whether frailty, a state of increased vulnerability to stressors, is associated with differences i...
journal_title：Clinical rheumatology
pub_type： 杂志文章,多中心研究
doi：10.1007/s10067-017-3541-9
更新日期：2017-05-01 00:00:00
abstract：:We compared the short-term effects of Stanger bath therapy and conventional exercises on spinal mobility, functional capacity, disease activity, and quality of life with conventional exercise alone in ankylosing spondylitis (AS) patients. A total of 58 patients with a diagnosis of AS according to the modified New York...
journal_title：Clinical rheumatology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10067-008-0873-5
更新日期：2008-07-01 00:00:00
abstract：:The aim of this study was to describe how persons with rheumatoid arthritis (RA) of working age experience and handle their fatigue in everyday life. Six focus group discussions were conducted focusing on experiences of fatigue in 25 persons with RA (19 women, 6 men), aged 20-60 years. The discussions were recorded, t...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-012-2133-y
更新日期：2013-05-01 00:00:00
abstract：:Type B insulin resistance syndrome is characterized by the formation of autoantibodies against insulin receptors, which can cause severe hyperglycemia and insulin resistance. Systemic lupus erythematosus is the most common underlying diseases of the syndrome. This report details our study of a case involving a Chinese...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-012-2098-x
更新日期：2013-02-01 00:00:00
abstract：:This study aims to evaluate the impact of arthritis on the physical function of people living in a Maya-Yucateco rural community and to assess the association of known modifiable risk factors with the prevalence of overall arthritis and its main types (osteoarthritis and rheumatoid arthritis). Using a cross-sectional,...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-015-3084-x
更新日期：2016-07-01 00:00:00
abstract：:A case of polymyositis associated with scleroderma, adult coeliac disease, diabetes mellitus and IgA nephropathy is reported in a 33-year-old male. ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02031278
更新日期：1984-12-01 00:00:00
abstract：:A cohort of patients with recently diagnosed axial spondyloarthritis (SpA) was characterized with emphasis on gender differences and factors leading to delay in diagnosis. Clinical, laboratory, and imaging data of 151 consecutive patients diagnosed with ankylosing spondylitis or undifferentiated SpA in 2004-2009 and s...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-011-1719-0
更新日期：2011-08-01 00:00:00
abstract：:To clarify the roles of neutrophils in anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitic neuropathy, we studied neutrophil extracellular traps (NETs) in peripheral nerve vasculitis. Stored nerve samples from 17 patients with microscopic polyangiitis (MPA) were immunohistochemically analyzed using a...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3546-4
更新日期：2017-04-01 00:00:00
abstract：:Identification of patients with exposure to viral hepatitis is an important part of the care of patients with inflammatory arthritis. This study was conducted to assess the extent of hepatitis B and C screening, and the prevalence of viral hepatitis in a cohort of patients with established rheumatoid arthritis (RA). T...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-014-2612-4
更新日期：2014-12-01 00:00:00
abstract：:Anti-nucleosome antibodies, which recognise conformational epitopes consisting of histone and DNA in chromatin, have been described in autoimmune diseases. In this study, an attempt was made to isolate anti-nucleosome antibodies from the anti-DNA-depleted plasma IgG of two lupus patients either with or without nephrit...
journal_title：Clinical rheumatology
pub_type： 临床试验,杂志文章
doi：10.1007/BF01451045
更新日期：1998-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:The purpose of this study was to develop an understanding of treatment preferences in patients with inflammatory arthritis (IA) [rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA)] focussing on treatment attributes that patients' value, their relative importan...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-019-04843-4
更新日期：2020-04-01 00:00:00
abstract：:Rheumatoid arthritis (RA) is associated with increased vascular calcification, although the rate of progress of calcification is uncertain. The aim of the study was to evaluate the progression of and the predictors for calcification in different vascular beds over 10 years. The 10-year actual coronary calcium score (C...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-016-3536-y
更新日期：2017-04-01 00:00:00
abstract：:We report the case of a 19-year-old woman who consulted for low-back pain 3 weeks after her first delivery. This young woman had a personal history of protein C deficiency and was treated daily during her pregnancy with low-molecular-weight heparin. Her body mass index was 34 and she only gained 10 kg during her pregn...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-008-0898-9
更新日期：2008-12-01 00:00:00
abstract：:Until recently, renal crisis was the most significant cause of morbidity and mortality in patients with scleroderma (SSc). Nowadays, following the introduction of angiotensin-converting enzyme inhibitors used in renovascular hypertension, pulmonary fibrosis and pulmonary hypertension have become the most common causes...
journal_title：Clinical rheumatology
pub_type： 临床试验,杂志文章
doi：10.1007/s100670050138
更新日期：1999-01-01 00:00:00
abstract：:The objective of the study is to determine the risk factors for the development of reactive arthritis (ReA) and examine the factors associated with the persistence of symptoms. Patients with a new diagnosis of ReA and controls with a gastrointestinal (GI), urogenital, or sexually transmitted infection in the 3-6 month...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3911-3
更新日期：2018-02-01 00:00:00
abstract：:To describe clinical and epidemiological data of Behçet's disease (BD) in Brazil, we retrospectively reviewed records of all patients seen between 2006 and 2007 at the BD outpatient clinic of University of Sao Paulo. One hundred and six patients fulfilled the International Study Group for Behçet's Disease diagnostic c...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-008-1081-z
更新日期：2009-05-01 00:00:00
abstract：OBJECTIVE:To determine clinical course and outcomes in rheumatic disease patients with coronavirus disease 2019 (COVID-19) and compare results to uninfected patients. METHODS:We conducted a case cohort study of autoimmune disease patients with COVID-19 (confirmed by severe acute respiratory syndrome coronavirus 2 PCR)...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-021-05578-x
更新日期：2021-01-09 00:00:00
abstract：:In a patient suffering from rheumatoid arthritis, we report the first simultaneous occurrence of two side effects of low-dose methotrexate: an acute megaloblastic anaemia and a pneumonitis. A combination of methotrexate suspension, folinic acid and corticosteroids led to recovery. The correlation between the haematolo...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02231787
更新日期：1993-12-01 00:00:00
abstract：:Little data exists from the developing world on pregnancy in systemic lupus erythematosus (SLE). A 10-year review of pregnancies in lupus patients was conducted at a tertiary hospital in a developing country. Forty-seven pregnancies in 31 patients were identified. Eleven (23%) booked after 20 weeks gestation. There we...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-007-0749-0
更新日期：2008-05-01 00:00:00
abstract：OBJECTIVES:This study evaluated Superb Microvascular Imaging (SMI) technology for detection of active synovitis in patients with rheumatoid arthritis (RA). METHODS:Between June 2015 and October 2016, 56 patients with RA (42 females; mean age, 53.2 years) underwent gray-scale ultrasound (US) imaging, power Doppler imag...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-019-04550-0
更新日期：2019-09-01 00:00:00
abstract：:Employing a recently developed questionnaire we studied the self-esteem structure of 61 female fibromyalgia (FM) patients by comparing them with i) 40 healthy psychology students and ii) 37 patients suffering from rheumatoid arthritis. Depressed FM patients (n=36) had a high need to gain self-esteem through competence...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02247798
更新日期：1997-11-01 00:00:00
abstract：:Spontaneous fractures of the sternum are rare but worth knowing as they may simulate acute cardiac and pulmonary emergencies. A case of an insufficiency sternal fracture mimicking myocardial infarction and subsequent anginal pain is presented. The risk factors of this condition, its clinical features and the diagnosti...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02207687
更新日期：1995-07-01 00:00:00
abstract：:This paper is to assess the efficacy of different biologic DMARDs (bDMARDs) on several patient-reported outcomes (PROs) in randomized controlled trials (RCT) in axial spondyloarthritis (axSpA). A systematic literature review (SLR) was performed. MEDLINE (May 1, 2018) was used with the filters "published in the last 10...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-020-05209-x
更新日期：2021-01-01 00:00:00
abstract：:To demonstrate an as yet merely postulated generalized osteopathy in psoriatics, the serum calcium level, the alkaline phosphatase in the serum and the urinary excretion of hydroxyproline were evaluated in 24 patients with Ps and 24 patients with PA. Moreover, the bone bioptates from 25 patients with PA and 10 patient...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02208026
更新日期：1991-03-01 00:00:00
abstract：:The objective of the study was to determine clinical factors associated with activity limitation and predictors of a change in activity limitation after 1 year in people with gout. Two hundred ninety-five participants with gout (disease duration < 10 years) attended a baseline assessment which included medical and dis...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-018-4110-6
更新日期：2018-08-01 00:00:00
abstract：:Macrophage activation syndrome (MAS), which can also be considered as reactive hemophagocytic syndrome (HPS), is a rare and potentially fatal complication of rheumatic diseases. We describe a 42-year-old woman in whom MAS developed as a complication of ankylosing spondylitis (AS). She suffered from fever and low back ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-007-0538-9
更新日期：2007-11-01 00:00:00
abstract：OBJECTIVE:The aim of the study was to evaluate the interrelationship between the micro- and macrovasculature. METHODS:This is a cross-sectional study that examined SSc patients and fibromyalgia (FM) patients as controls. We assessed forearm peripheral vascular status and nailfold capillaroscopy. We evaluated the assoc...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05025-3
更新日期：2020-09-01 00:00:00
abstract：:As a class, tumor necrosis factor (TNF)-alpha inhibitors have provided clinicians significant control over chronic inflammatory diseases. With their widespread use has come the emergence of new side effects such as the reactivation of latent infections. One such infection that may reactivate is the hepatitis B virus (...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-010-1523-2
更新日期：2010-09-01 00:00:00
abstract：PURPOSE:To explore the 18F-fluoro-dexoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) imaging characteristics of adult-onset Still's disease (AOSD) and its significance in differential diagnosis from other connective tissue diseases (CTDs). METHODS:FDG PET/CT images of 54 patients with AOSD...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05041-3
更新日期：2020-09-01 00:00:00
