Abstract:
:To clarify the roles of neutrophils in anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitic neuropathy, we studied neutrophil extracellular traps (NETs) in peripheral nerve vasculitis. Stored nerve samples from 17 patients with microscopic polyangiitis (MPA) were immunohistochemically analyzed using antibodies for citrullinated histone H3 (citH3) and various neutrophil enzymes. We defined merged citH3 and extracellularly released myeloperoxidase (MPO) as NET formation. We also compared NET formation between MPO-ANCA-positive/negative MPA and rheumatoid arthritis (RA)-associated vasculitic neuropathy. NETs were identified mostly in vasculitic small arterioles of 6 of 12 MPO-ANCA-positive MPA patients, and their frequency was higher (p < 0.05) than in ANCA-negative patients. NETs were not found in vasculitic neuropathy with RA or patients with chronic inflammatory demyelinating polyradiculoneuropathy. NETs were also observed in the peripheral nervous system of MPA patients as well as in the lung and kidney. These results suggest that NETs may be involved in the pathogenesis of MPA neuropathy.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Takeuchi H,Kawasaki T,Shigematsu K,Kawamura K,Oka Ndoi
10.1007/s10067-017-3546-4subject
Has Abstractpub_date
2017-04-01 00:00:00pages
913-917issue
4eissn
0770-3198issn
1434-9949pii
10.1007/s10067-017-3546-4journal_volume
36pub_type
杂志文章abstract::The objective of this study is to identify baseline factors associated with rheumatoid arthritis (RA) diagnosis at the end of 1-year follow-up in a cohort of patients with very recent onset arthritis. Incident cases with self-reported arthritis ( journal_title:Clinical rheumatology pub_type: 杂志文章 doi:10.1007/s10067-009-1206-z 更新日期:2009-10-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 历史文章,杂志文章
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更新日期:2008-09-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
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更新日期:2001-01-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1007/s10067-012-2035-z
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journal_title:Clinical rheumatology
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journal_title:Clinical rheumatology
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journal_title:Clinical rheumatology
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