Neutrophil extracellular traps in neuropathy with anti-neutrophil cytoplasmic autoantibody-associated microscopic polyangiitis.


:To clarify the roles of neutrophils in anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitic neuropathy, we studied neutrophil extracellular traps (NETs) in peripheral nerve vasculitis. Stored nerve samples from 17 patients with microscopic polyangiitis (MPA) were immunohistochemically analyzed using antibodies for citrullinated histone H3 (citH3) and various neutrophil enzymes. We defined merged citH3 and extracellularly released myeloperoxidase (MPO) as NET formation. We also compared NET formation between MPO-ANCA-positive/negative MPA and rheumatoid arthritis (RA)-associated vasculitic neuropathy. NETs were identified mostly in vasculitic small arterioles of 6 of 12 MPO-ANCA-positive MPA patients, and their frequency was higher (p < 0.05) than in ANCA-negative patients. NETs were not found in vasculitic neuropathy with RA or patients with chronic inflammatory demyelinating polyradiculoneuropathy. NETs were also observed in the peripheral nervous system of MPA patients as well as in the lung and kidney. These results suggest that NETs may be involved in the pathogenesis of MPA neuropathy.


Clin Rheumatol


Clinical rheumatology


Takeuchi H,Kawasaki T,Shigematsu K,Kawamura K,Oka N




Has Abstract


2017-04-01 00:00:00














  • Very recent onset arthritis: the value of initial rheumatologist evaluation and anti-cyclic citrullinated peptide antibodies in the diagnosis of rheumatoid arthritis.

    abstract::The objective of this study is to identify baseline factors associated with rheumatoid arthritis (RA) diagnosis at the end of 1-year follow-up in a cohort of patients with very recent onset arthritis. Incident cases with self-reported arthritis (

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Rojas-Serrano J,Burgos-Vargas R,Pérez LL,García CG,Moctezuma F,Vázquez-Mellado J

    更新日期:2009-10-01 00:00:00

  • Evening primrose oil and olive oil in treatment of rheumatoid arthritis.

    abstract::The effects of 10 ml of evening primrose oil or olive oil, administered twice daily for 12 weeks, on clinical and laboratory signs and on plasma prostaglandins were studied in 18 patients with rheumatoid arthritis. The plasma concentration of PGE2 decreased and that of TxB2 increased in both treatment groups, but no s...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Jäntti J,Seppälä E,Vapaatalo H,Isomäki H

    更新日期:1989-06-01 00:00:00

  • Dickkopf-1 (Dkk-1) serum levels in systemic sclerosis and rheumatoid arthritis patients: correlation with the Trabecular Bone Score (TBS).

    abstract::The aim of this research was to determine any correlations between Dickkopf-1 serum levels (Dkk-1, a natural inhibitor of the Wnt signaling pathway promoting osteoclastogenesis) and the Trabecular Bone Score (TBS), in systemic sclerosis (SSc) and rheumatoid arthritis (RA) patients. It also aimed at determining any dif...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Ruaro B,Casabella A,Paolino S,Pizzorni C,Ghio M,Seriolo C,Molfetta L,Odetti P,Smith V,Cutolo M

    更新日期:2018-11-01 00:00:00

  • Methicillin-resistant Staphylococcus aureus septic arthritis: urgent and emergent.

    abstract::A 71-year-old male rheumatoid patient presented with MRSA septic arthritis. The impact of this organism on musculoskeletal practice is discussed. ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Byrne PA,Hosein IK,Camilleri J

    更新日期:1998-01-01 00:00:00

  • Subacute cutaneous lupus erythematosus associated with Hodgkin's disease.

    abstract::Simultaneous occurrence of subacute cutaneous lupus erythematosus and malignancy has rarely been reported. We report the first case of subacute cutaneous lupus erythematosus associated with Hodgkin's disease. Although our case does not fulfill the criteria of paraneoplastic process, a relationship between the two diso...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Castanet J,Taillan B,Lacour JP,Garnier G,Perrin C,Ortonne JP

    更新日期:1995-11-01 00:00:00

  • Experience with azathioprine in systemic sclerosis associated with interstitial lung disease.

    abstract::The aim of this study was to evaluate the safety and efficacy of azathioprine in the treatment of interstitial lung disease (ILD) associated with systemic sclerosis (SSc). The records of patients with SSc with ILD who were treated with azathioprine were reviewed. Patients were treated with azathioprine and low-dose pr...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Dheda K,Lalloo UG,Cassim B,Mody GM

    更新日期:2004-08-01 00:00:00

  • The role of outcome expectancies for a training program consisting of meditation, breathing exercises, and cold exposure on the response to endotoxin administration: a proof-of-principle study.

    abstract::Expectancies play a major role for the treatment outcome of a broad variety of immune-mediated conditions and may strengthen or mimic the effects of regular long-term therapies. This study adds to a recently published study of Kox et al. (PNAS 111:7379-7384, 2014) on the ability to voluntarily influence the physiologi...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,随机对照试验


    authors: van Middendorp H,Kox M,Pickkers P,Evers AW

    更新日期:2016-04-01 00:00:00

  • Brief report: Decreased expression of CD244 (SLAMF4) on monocytes and platelets in patients with systemic lupus erythematosus.

    abstract::The signalling lymphocyte activation molecule (SLAM) family receptors play important roles in modulating immune responses. Previous studies in murine models and patients have suggested an association of the SLAM family (SLAMF) members with the development of autoimmunity, particularly systemic lupus erythematosus (SLE...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Mak A,Thornhill SI,Lee HY,Lee B,Poidinger M,Connolly JE,Fairhurst AM

    更新日期:2018-03-01 00:00:00

  • Rich but poor: life in the Roman period with extreme rheumatoid arthritis.

    abstract::In a Sidonian sarcophagus, from the Late Antique/early Christian period, skeletal remains of two persons were found. One of them, male, 30-50 years old, was found almost completely ankylosed, with highly osteoporotic bones and prominent erosion of joint surfaces. We diagnosed rheumatoid arthritis based on the eroded o...

    journal_title:Clinical rheumatology

    pub_type: 历史文章,杂志文章


    authors: Bašić Ž,Jerković I,Kružić I,Anđelinović Š

    更新日期:2017-01-01 00:00:00

  • Functional limitation and associated factors in outpatients with ankylosing spondylitis in Southwest China.

    abstract::Functional limitation is often complained by patients with ankylosing spondylitis (AS). With a rising number of patients suffering from AS, there are a limited number of reports focusing on functional limitation of AS in Chinese patients. This study was conducted to investigate the level of functional limitation and e...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Song Y,Wang C,Chen H

    更新日期:2017-04-01 00:00:00

  • Mean platelet volume in children with familial Mediterranean fever.

    abstract::Familial Mediterranean fever (FMF) is the most common inherited periodic fever syndrome characterized by recurrent episodes of serositis. Recently, a few studies have suggested that FMF is related to increased risk of atherosclerosis. Mean platelet volume (MPV) is a marker of platelet activation. Larger platelets are ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Makay B,Türkyilmaz Z,Unsal E

    更新日期:2009-08-01 00:00:00

  • An unusual case of autoimmune hepatitis in a patient with adult-onset Still's disease.

    abstract::Adult-onset Still's disease (AOSD) is an autoimmune disease characterized by spiking fever, evanescent rash, arthritis, serositis, and liver involvement. Although autoimmune hepatitis (AIH) has been reported in association with various autoimmune diseases, AOSD-associated AIH is rare. We herein report an unusual case ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Xia LX,Xiao T

    更新日期:2010-01-01 00:00:00

  • Self-reported sleep in systemic lupus erythematosus.

    abstract::The objectives of the study were to assess sleep disturbances in systemic lupus erythematosus (SLE) and to compare these with a working sample and a treatment-seeking sample reporting insomnia. The primary sample was 172 people with SLE. This sample represented 32% of all members of two lupus support association. Two ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Greenwood KM,Lederman L,Lindner HD

    更新日期:2008-09-01 00:00:00

  • Upregulation of CD16- monocyte subsets in systemic lupus erythematous patients.

    abstract::Monocytes are an important component in the innate immune system. However, studies to date have failed to conclude whether their levels are altered in patients with systemic lupus erythematosus (SLE). We applied the cytodiff counting method and comprehensively measured the circulating levels of distinct white blood ce...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Wu Z,Zhang S,Zhao L,Fei Y,Wang L,Li J,Wen X,Zeng X,Zhang F,Li Y

    更新日期:2017-10-01 00:00:00

  • Impact of treatment with TNF antagonists on total cholesterol in patients with ankylosing spondylitis and psoriatic arthritis.

    abstract::The objective of the study was to analyze the impact of TNF antagonists (TNFa) on the total cholesterol and triglycerides on ankylosing spondylitis (AS) and psoriatic arthritis (PsA). In this single-centre observational study of AS and PsA patients, differences in triglyceride and total cholesterol levels and frequenc...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Maneiro JR,Souto A,Gomez-Reino JJ

    更新日期:2017-05-01 00:00:00

  • Spondylodiscitis due to Candida tropicalis as a cause of inflammatory back pain.

    abstract::Spondylodiscitis may be either infectious or rheumatic in origin. In the latter case it may be seen more often in the context of spondyloarthropathies, giving rise to inflammatory back pain. We report the case of a man, affected by ulcerative colitis and carcinoma of the colon, who developed spondylodiscitis due to in...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Sebastiani GD,Galas F

    更新日期:2001-01-01 00:00:00

  • Clinical features and expression of type I interferon-inducible genes in systemic lupus erythematosus patients harboring rs1143679 polymorphism in China: a single-center, retrospective study.

    abstract:OBJECTIVE:This case-control study aimed to analyze the clinical features and determine the expression of type I interferon-induced genes in systemic lupus erythematosus (SLE) patients harboring the CD11b rs1143679 single-nucleotide polymorphism (SNP) and elucidate whether it is involved in the relapses of SLE. METHODS...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Xu W,Zhang Y,Wang X,Liu P,Gao D,Gu B,Zhang J,Li C,Ren Q,Yang L,Yuan H,Shen M,Chen X

    更新日期:2020-08-12 00:00:00

  • Risedronate-associated scleritis: a case report and review of the literature.

    abstract::This paper presents the first reported case of risedronate-associated scleritis and conducts a review of bisphosphonates and inflammatory eye diseases. A case of scleritis associated with risedronate use in a 73-year-old Chinese woman is reported. The English medical literature was reviewed for bisphosphonates and the...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审


    authors: Hemmati I,Wade J,Kelsall J

    更新日期:2012-09-01 00:00:00

  • Calciphylaxis in a patient with rheumatoid arthritis without renal failure and hyperparathyroidism: the possible role of long-term steroid use and protein S deficiency.

    abstract::Calciphylaxis is a rare and life-threatening condition of progressive cutaneous necrosis secondary to small and medium-sized vessel calcification that is seen almost exclusively in patients with end-stage renal disease and hyperparathyroidism. We report a case of calciphylaxis that may very well be due to a long-term ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Korkmaz C,Dündar E,Zubaroğlu I

    更新日期:2002-02-01 00:00:00

  • Systemic mastocytosis, an unusual cause of osteoporosis.

    abstract::A 45-year-old patient is described presenting with severe axial osteoporosis. The presence of maculopapular skin lesions and the combination of osteolytic and osteoblastic bone lesions led to the tentative diagnosis of systemic mastocytosis. This diagnosis was confirmed by measurement of urinary histamine metabolites ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Schoenaers P,De Clerck LS,Timmermans U,Stevens WJ

    更新日期:1987-09-01 00:00:00

  • The effect of colchicine and disease severity on physical growth in children with familial Mediterranean fever.

    abstract::This study aimed to investigate the effects of colchicine on growth parameters in familial Mediterranean fever (FMF) patients. Fifty-one (29 girls, 22 boys) FMF patients were enrolled in the study. All of the patients were in the prepubertal stage and had not received colchicine treatment before the study. Anthropomet...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Yoldaş TÇ,Çakar N,Başaran Ö,Acar B,Uncu N,Çaycı FŞ

    更新日期:2016-06-01 00:00:00

  • Effect of delayed diagnosis on disease course and management of Churg-Strauss syndrome: a retrospective study.

    abstract::Delayed diagnosis in patients with Churg-Strauss syndrome (CSS) is largely attributed to the variable and nonspecific presentation of the disease's initial symptoms. The aim of the study was to evaluate the effect of delayed diagnosis on the course of CSS. We conducted a retrospective study of 30 CSS patients followed...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Sokołowska B,Szczeklik W,Mastalerz L,Kuczia P,Wodkowski M,Stodółkiewicz E,Macioł K,Musiał J

    更新日期:2013-03-01 00:00:00

  • Anxiety and depression in adult-onset Still's disease patients and associations with health-related quality of life.

    abstract:OBJECTIVE:Adult-onset Still's disease (AOSD) is an autoinflammatory disorder leading to multiorgan involvements. We sought to investigate mood status and the health-related quality of life (HRQoL) in these patients. METHODS:In this study, 82 AOSD patients and 82 age- and sex-matched healthy controls were included. Dem...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Chi H,Jin H,Wang Z,Feng T,Zeng T,Shi H,Wu X,Wan L,Teng J,Sun Y,Liu H,Cheng X,Ye J,Hu Q,Zhou Z,Gu J,Jia J,Liu T,Qiao X,Yang C,Su Y

    更新日期:2020-12-01 00:00:00

  • Bone mass in Zaireans: radiogrammetric determination.

    abstract::Bone mass was measured in 230 subjects with ages ranging from 15 to 54 years (110 males and 120 females), using the radiogrammetric method on the second metacarpal bone. Results of the study show that bone mass increases with age up to 34 years and then decreases, both in males and females, although males have signifi...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Kabeya JM,Mbuyi Muamba JM,Tozin R,Dequeker J

    更新日期:1995-01-01 00:00:00

  • Management of anti-HBc-positive patients with rheumatic diseases treated with disease-modifying antirheumatic drugs-a single-center analysis of 2054 patients.

    abstract::Hepatitis B virus (HBV) reactivation is a common complication of immunosuppressive treatment in high prevalence countries. Biological disease-modifying antirheumatic drugs (bDMARDs) cause this adverse event more often than conventional immunosuppressants. The incidence of HBV reactivation during treatment for rheumati...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Schwaneck EC,Krone M,Kreissl-Kemmer S,Weißbrich B,Weiss J,Tony HP,Gadeholt O,Schmalzing M,Geier A

    更新日期:2018-11-01 00:00:00

  • Prevalence of IgA class antibodies to cyclic citrullinated peptide (anti-CCP) in patients with primary Sjögren's syndrome, and its association to clinical manifestations.

    abstract::This study aims to determine the prevalence and clinical significance of anti-CCP isotype IgA in a population of patients with primary Sjögren's syndrome (pSS). Sixty-two patients diagnosed according to the USA-European classification criteria for pSS were examined two to four times during a 60.4-month follow-up, and ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Haga HJ,Andersen DT,Peen E

    更新日期:2011-03-01 00:00:00

  • Evaluation of the incidence of haemorrhoidal disease in patients with ankylosing spondylitis.

    abstract::Haemorrhoidal disease (HD) is one of the most common diseases encountered by the clinicians of general surgery. Chronic constipation, pushing during defecation and increased abdominal pressure play an important role in development of haemorrhoidal disease. Patients with ankylosing spondylitis (AS) frequently use the V...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Caglayan M,Türkoğlu A,Oktayoglu P,Yıldız M,Dağlı AZ,Böyük A,Em S,Bozkurt M,Nas K

    更新日期:2015-03-01 00:00:00

  • An adolescent girl with Meyer-Betz syndrome.

    abstract::Idiopathic paroxysmal rhabdomyolysis indicating a classical triad of symptoms consisting of muscle pain, weakness, and discolored urine is known as "Meyer-Betz syndrome". It may result in acute renal failure due to precipitation of the myoglobin casts in the tubuli or to the direct toxic effects of myoglobin to the tu...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Kasap B,Soylu A,Türkmen M,Kavukcu S

    更新日期:2006-11-01 00:00:00

  • A case of Sjögren's syndrome complicating immune-mediated aplastic anaemia.

    abstract::A 78-year-old Japanese woman with Sjögren's syndrome complicating immune-mediated aplastic anaemia is described. A diagnosis of aplastic anaemia was made from severe pancytopenia with hypoplastic marrow. Laboratory studies suggested an association of bone marrow suppressive T-lymphocytes with the pathogenesis of aplas...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Satoh M,Yamagata H,Watanabe F,Matsushita Y,Nakayama S,Murakami M,Matsuyama J,Oshima S,Akizuki M

    更新日期:1993-06-01 00:00:00

  • Increased seropositivity of Helicobacter pylori cytotoxin-associated gene-A in Behçet's disease.

    abstract::Behçet's disease is a systemic vasculitic syndrome with unknown etiology. The aim of the present study was to compare the Helicobacter pylori seropositivity and cytotoxin associated gene-A status in patients with Behçet's disease. Ninety-one patients with Behçet's disease and 83 age- and sex-matched persons with or wi...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Apan TZ,Gürsel R,Dolgun A

    更新日期:2007-06-01 00:00:00