Abstract：
OBJECTIVE:The aim of the study was to evaluate the interrelationship between the micro- and macrovasculature. METHODS:This is a cross-sectional study that examined SSc patients and fibromyalgia (FM) patients as controls. We assessed forearm peripheral vascular status and nailfold capillaroscopy. We evaluated the association between nailfold capillaroscopy pattern of microvasculopathy reflected as microangiopathy evolution score and macrovascular changes in the forearm vessels examined by color Doppler ultrasound. We assessed relevant clinical and laboratory data, as well as intima-media thickness (IMT) and internal diameter (ID) in the radial and ulnar arteries in millimeters, and calculated the ratio IMT\ID peak systolic velocity and end-diastolic velocity were used for the calculation of the resistance index. RESULTS:We examined 73 patients: 50 patients with SSc and 23 patients with FM. Ten patients with SSc had arterial occlusions compared to 1 among FM patients (p = 0.082). The SSc group had a statistically significantly higher mean IMT to ID ratio (p < 0.001). There was no correlation between microangiopathy evolution score for both hands, RI, or mean IMT/ID ratio. Total microangiopathy evolution score was not associated with arterial occlusions. CONCLUSIONS:Our study demonstrated a high prevalence of macrovascular disease in SSc; no correlation was found between microvasculopathy and macrovascular disease, suggesting that different pathogenic mechanisms might operate in different vessels size. Key Points • This study demonstrated a high prevalence of macrovascular arterial forearm disease in systemic sclerosis patients. • This study found no correlation between capillaroscopic microangiopathy evolution score (MES) and macrovascular abnormalities. • Our findings suggest that different pathogenic mechanisms might operate in different vessels size.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Bieber A,Dolnikov K,Chizik V,Novofastovsky I,Fawaz A,Balbir-Gurman A,Mader Rdoi
10.1007/s10067-020-05025-3subject
Has Abstractpub_date
2020-09-01 00:00:00pages
2671-2676issue
9eissn
0770-3198issn
1434-9949pii
10.1007/s10067-020-05025-3journal_volume
39pub_type
杂志文章abstract：:Rheumatoid arthritis (RA) is a progressive inflammatory disease. Although the etiology and pathogenesis of RA are not known well, genetic and environmental factors are proposed to initiate an autoimmune process. We aimed to investigate mRNA expression levels of Toll-like receptor-2 (TLR-2), TLR-4, and interleukin-6 (I...
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journal_title：Clinical rheumatology
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更新日期：2013-12-01 00:00:00
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更新日期：1995-05-01 00:00:00
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更新日期：2004-06-01 00:00:00
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