ASAS classification criteria for axial spondyloarthritis: time to modify.

Abstract:

:The relationship between ankylosing spondylitis and the recently proposed entity called axial spondyloarthritis with its radiographic and non-radiographic forms that have been defined by the Assessment of Spondyloarthritis International Society (ASAS) criteria for axial spondyloarthritis (axSpA), is currently being debated. The Food and Drug Agency (FDA) had criticized the ASAS criteria and the studies which used these criteria to enroll patients in a clinical trial of certolizumab and adalimumab for the treatment of non-radiographic axial spondyloarthritis. The primary aim of classification criteria is to create homogenous patient populations for basic and clinical research. But the multi-arm construct of the ASAS criteria is a potential source of heterogeneity reducing their utility. Criteria sets should be regarded as dynamic concepts open to modifications or updates as our knowledge advances. We provide evidence to conclude that it is time to modify the ASAS Criteria for axSpA, and we propose some of the steps that can be taken to start moving forward in improving the validity of these criteria.

journal_name

Clin Rheumatol

journal_title

Clinical rheumatology

authors

Akkoc N,Khan MA

doi

10.1007/s10067-016-3261-6

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

1415-23

issue

6

eissn

0770-3198

issn

1434-9949

pii

10.1007/s10067-016-3261-6

journal_volume

35

pub_type

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