Evaluation of response to methotrexate by a functional index in juvenile chronic arthritis.


:In juvenile chronic arthritis (JCA) the indices of disease activity, such as joint swelling, pain, tenderness, and limitation of motion, may poorly correlate with the degree of functional impairment. Since the improvement of functional capacity is one of the main objectives of treatment, we evaluated the effect of methotrexate (MTX) in 29 children with JCA by assessing both the articular indices and a functional status measure. After 6 months of therapy, 15 of the 29 patients had a significant (> or = 50%) reduction in the number of joints with active arthritis and/or the articular severity score and were then judged as responders, while 14 did not respond to MTX. In the responder group, the median functional index score decreased from 17 (range: 13-27) at baseline to 13 (range: 13-15) at 6 months (p < 0.001); the median score of the non-responder group was 20 both at baseline and at 6 months (ranges: 14-27, and 13-36, respectively). These results show an improvement of functional impairment in those patients who respond to MTX according to the conventional indices of articular inflammation.


Clin Rheumatol


Clinical rheumatology


Ravelli A,Viola S,Ramenghi B,Di Fuccia G,Ruperto N,Zonta L,Martini A




Has Abstract


1995-05-01 00:00:00












  • Infliximab in Takayasu arteritis: a safe alternative?

    abstract:OBJECTIVE:To test the efficacy of Infliximab, a chimeric monoclonal antibody against TNF-alpha, in the treatment of Takayasu arteritis. MATERIALS AND METHODS:We used infliximab at an initial dose of 3 mg/kg i.v. at weeks 0, 2, 6, and 8 thereafter in combination with methotrexate or azathioprine, to treat four patients...

    journal_title:Clinical rheumatology

    pub_type: 临床试验,杂志文章


    authors: Karageorgaki ZT,Mavragani CP,Papathanasiou MA,Skopouli FN

    更新日期:2007-06-01 00:00:00

  • Detection of asymptomatic cranial neuropathies in patients with systemic lupus erythematosus and their relation to antiribosomal P antibody levels and disease activity.

    abstract::The objectives of this study are to assess the risk of asymptomatic cranial neuropathy among patients with systemic lupus erythematosus (SLE) and find any association with disease activity and antiribosomal P antibodies. This study is a case-control study including 60 female patients and 30 healthy female controls. Di...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Gaber W,Ezzat Y,El Fayoumy NM,Helmy H,Mohey AM

    更新日期:2014-01-01 00:00:00

  • Differences in clinical Pneumocystis pneumonia in rheumatoid arthritis and other connective tissue diseases suggesting a rheumatoid-specific interstitial lung injury spectrum.

    abstract::To compare Pneumocystis pneumonia (PCP) in patients with rheumatoid arthritis (RA) with PCP in patients with non-RA connective tissue diseases (CTDs) in order to clarify the characteristics of the former. We extracted consecutive patients satisfying the following criteria for "clinical PCP": (1) positive plasma β-D-gl...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Shimada K,Yokosuka K,Nunokawa T,Sugii S

    更新日期:2018-08-01 00:00:00

  • Headache may be a risk factor for complex regional pain syndrome.

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    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Toda K,Muneshige H,Maruishi M,Kimura H,Asou T

    更新日期:2006-09-01 00:00:00

  • Comorbidity of gout and rheumatoid arthritis in a large population database.

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    journal_title:Clinical rheumatology

    pub_type: 杂志文章


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    更新日期:2017-03-01 00:00:00

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    journal_title:Clinical rheumatology

    pub_type: 杂志文章,随机对照试验


    authors: van Middendorp H,Kox M,Pickkers P,Evers AW

    更新日期:2016-04-01 00:00:00

  • Functioning and health-related quality of life in Chinese patients with systemic sclerosis: a case-control study.

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    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Chan PT,Mok CC,Chan KL,Ho LY

    更新日期:2014-05-01 00:00:00

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    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Byrne PA,Hosein IK,Camilleri J

    更新日期:1998-01-01 00:00:00

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    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Bolla G,Disdier P,Harle JR,Verrot D,Weiller PJ

    更新日期:1993-12-01 00:00:00

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    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Navarro-Compán V,Moreira V,Ariza-Ariza R,Hernández-Cruz B,Vargas-Lebrón C,Navarro-Sarabia F

    更新日期:2011-07-01 00:00:00

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    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Chimenti MS,Triggianese P,Conigliaro P,Tonelli M,Gigliucci G,Novelli L,Teoli M,Perricone R

    更新日期:2017-10-01 00:00:00

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    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Wang CR,Liu MF,Tsai RT,Chuang CY,Chen CY

    更新日期:1993-09-01 00:00:00

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    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审


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    更新日期:2011-02-01 00:00:00

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    journal_title:Clinical rheumatology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


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    更新日期:1996-09-01 00:00:00

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    journal_title:Clinical rheumatology

    pub_type: 杂志文章


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    更新日期:2019-01-01 00:00:00

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    journal_title:Clinical rheumatology

    pub_type: 杂志文章


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    更新日期:2020-09-01 00:00:00

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    journal_title:Clinical rheumatology

    pub_type: 杂志文章


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    更新日期:2013-06-01 00:00:00

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    pub_type: 杂志文章


    authors: Salvarani C,Zizzi F,Macchioni P,Mantovani W,Rossi F,Baricchi R,Bellelli A,Capozzoli N,Frizziero L,Portioli I

    更新日期:1989-03-01 00:00:00

  • High expression levels of microRNA-629, microRNA-525-5p and microRNA-516a-3p in paediatric systemic lupus erythematosus.

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    pub_type: 杂志文章


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    更新日期:2014-06-01 00:00:00

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    更新日期:2008-03-01 00:00:00

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    journal_title:Clinical rheumatology

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    更新日期:2012-04-01 00:00:00

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    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Rostom S,Bahiri R,Hajjaj-Hassouni N

    更新日期:2008-02-01 00:00:00

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    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审


    authors: Akkoc N,Khan MA

    更新日期:2016-06-01 00:00:00

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    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Cong XL,Dai SM,Feng X,Wang ZW,Lu QS,Yuan LX,Zhao XX,Zhao DB,Jing ZP

    更新日期:2010-09-01 00:00:00

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    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Loyola-Sanchez A,Richardson J,Pelaez-Ballestas I,Alvarez-Nemegyei J,Lavis JN,Wilson MG,Wilkins S

    更新日期:2016-07-01 00:00:00

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    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Salaffi F,Filosa G,Bugatti L,Maestrini MD

    更新日期:2000-01-01 00:00:00

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    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Isnardi CA,Schneeberger EE,Capelusnik D,de Los Ángeles Correa M,Lim R,Hu M,Tapia MJ,Kerzberg E,Blanco E,Benavidez FL,Gonzales Lucero L,Barbaglia AL,Bazzarelli M,Ficco HM,Pérez S,Hartvig C,Salcedo M,Citera G

    更新日期:2020-11-01 00:00:00