Abstract：
:Severe thrombocytopenia with bleeding associated with a life-threatening thrombotic manifestation in the setting of antiphospholipid syndrome is a major diagnostic and therapeutic challenge for the clinician. Hemorrhage is a less common complication than thrombosis in patients with APS, although severe thrombocytopenia can sometimes result in bleeding. There are no evidence-based guidelines regarding the management of a patient with severe thrombocytopenia associated with a major thrombotic manifestation. In this case report, we review the literature reporting the difficulties in management of such patient.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Nyo MT,Kalla AAdoi
10.1007/s10067-013-2416-ysubject
Has Abstractpub_date
2014-04-01 00:00:00pages
587-90issue
4eissn
0770-3198issn
1434-9949journal_volume
33pub_type
杂志文章,评审abstract：:Four patients with rheumatoid nodulosis are here described, together with a review of cases reported to date in the literature. This particular variant of rheumatoid arthritis (RA) is characterized by the presence of subcutaneous rheumatoid nodules, scanty or absent systemic manifestations and a clinically benign cour...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02207201
更新日期：1992-09-01 00:00:00
abstract：:Ultrasound elastography (UE) is a new ultrasound-based imaging technique that provides information about elasticity and stiffness of tissues. This cross-sectional study aimed to identify the diagnostic importance of UE in supraspinatus impingement syndrome. Forty-one subjects, aged 38-70 years, were included in the st...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3928-7
更新日期：2018-06-01 00:00:00
abstract：:A patient presenting with interstitial lung disease was predicted to have underlying polymyositis when found to be anti-Jo-1 antibody positive. When myopathy developed later with elevated serum creatine phosphokinase and myoglobin levels, the electromyogram was nonmyopathic, and polymyositis was confirmed by muscle bi...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02201038
更新日期：1987-06-01 00:00:00
abstract：:A 45-year-old patient is described presenting with severe axial osteoporosis. The presence of maculopapular skin lesions and the combination of osteolytic and osteoblastic bone lesions led to the tentative diagnosis of systemic mastocytosis. This diagnosis was confirmed by measurement of urinary histamine metabolites ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02206850
更新日期：1987-09-01 00:00:00
abstract：:Identification of patients with exposure to viral hepatitis is an important part of the care of patients with inflammatory arthritis. This study was conducted to assess the extent of hepatitis B and C screening, and the prevalence of viral hepatitis in a cohort of patients with established rheumatoid arthritis (RA). T...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-014-2612-4
更新日期：2014-12-01 00:00:00
abstract：:The aim of the study was to investigate the long-term outcome of non-specific seronegative oligoarthritis in adults. The study included 64 adult patients with recent (<6 months) seronegative oligoarthritis (rheumatoid factor negative, number of swollen joints 1-4 during the first 6 months). Follow-up examinations were...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s100670200096
更新日期：2002-09-01 00:00:00
abstract：:Functional limitation is often complained by patients with ankylosing spondylitis (AS). With a rising number of patients suffering from AS, there are a limited number of reports focusing on functional limitation of AS in Chinese patients. This study was conducted to investigate the level of functional limitation and e...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3563-3
更新日期：2017-04-01 00:00:00
abstract：:This study aims to identify the clinical predictors of arthritis in patients with psoriasis and to evaluate the use of musculoskeletal ultrasonography (US) as a predictor for inflammatory structural progression in psoriatic patients. Measures of association (odds ratio (OR)) were tested, in a prospective, cohort 1-yea...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-014-2630-2
更新日期：2015-02-01 00:00:00
abstract：:This study aims to explore the effectiveness of low dose of etanercept (ETN) in patients with ankylosing spondylitis (AS) who achieve a good control of their disease in daily clinical practice. This is a case series of AS patients treated with ETN. According to the judgment of the treating rheumatologist and patient's...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-011-1722-5
更新日期：2011-07-01 00:00:00
abstract：:Clinical characteristics of antitumor necrosis factor (TNF) agents-related tuberculosis (TB) in ankylosing spondylitis (AS) are not well described. The aim was to compare the incidences and the characteristics of TB in AS and rheumatoid arthritis (RA) during TNF inhibitor treatment. AS (n = 1,322) and RA (n = 3,154) p...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-013-2387-z
更新日期：2014-09-01 00:00:00
abstract：:Ophthalmic involvement is the most debilitating complication of Behcet's disease (BD). The aim of the current study is to report on the efficacy and safety of a long-term use of interferon alpha-2a (IFNα-2a) in the treatment of refractory ophthalmic BD in the Azari population of Iran. We retrospectively analyzed the c...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-016-3318-6
更新日期：2016-11-01 00:00:00
abstract：:Biologic therapies have brought improved efficacy in the field of rheumatoid arthritis (RA), but their use in clinical practice may be limited by concerns over cost. Predictive models are, therefore, needed to identify those people with RA with the worst potential outcomes, who will benefit most from the use of these ...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-010-1639-4
更新日期：2011-03-01 00:00:00
abstract：:Juvenile systemic lupus erythematosus (JSLE) is a multi-system autoimmune inflammatory disease. Generally, 60% of patients will develop lupus nephritis (LN); thus, early recognition and treatment is associated with better outcome. Interleukin 22 (IL-22) is involved in tissue inflammation and is regulated by interleuki...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3812-5
更新日期：2018-02-01 00:00:00
abstract：:Matrix metalloproteinases (MMPs) are the key enzymes responsible for the joint destruction. Their activity is regulated by the level of proinflammatory cytokines. The aim of this study was to examine the impact of TNF-α G-308A polymorphism on MMP-9 levels in blood plasma (BP) and synovial fluid (SF) of patients with r...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3699-1
更新日期：2017-07-01 00:00:00
abstract：:Neurological involvement is uncommon in systemic sclerosis. Most of the reported cases concern trigeminal neuropathy or peripheral nerve entrapment. We report a third case of brachial plexopathy, presumably related to vasculitis, in a patient with systemic sclerosis, which improved after cyclophosphamide therapy. ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s100670200106
更新日期：2002-09-01 00:00:00
abstract：:Behçet's disease (BD) related amyloidosis is relatively rare. Serum amyloid A protein (SAA) protein gene polymorphism is one of the factors implicated in the pathogenesis of AA type amyloidosis. The aim of this study is to investigate SAA1 gene polymorphism in different patient groups: (1) BD related amyloidosis, (2) ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-006-0435-7
更新日期：2007-06-01 00:00:00
abstract：:The effect of the immunostimulant C. parvum on the establishment and course of mycoplasma arthritis of mice was investigated. Male Swiss albino mice were injected intra-venously with M. arthritidis culture and intraperitoneally with C. parvum. It was shown that mice immunostimulated with C. parvum were significantly p...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02032174
更新日期：1983-06-01 00:00:00
abstract：:This study aims to determine the prevalence and clinical significance of anti-CCP isotype IgA in a population of patients with primary Sjögren's syndrome (pSS). Sixty-two patients diagnosed according to the USA-European classification criteria for pSS were examined two to four times during a 60.4-month follow-up, and ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-010-1675-0
更新日期：2011-03-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:ABP 798 is a proposed biosimilar to the originator biologic rituximab, an anti-CD20 monoclonal antibody. This comparative clinical study evaluated the pharmacokinetics (PK), safety, and efficacy of ABP 798 versus rituximab reference product (RP) in patients with moderate-to-severe rheumatoid arthr...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05305-y
更新日期：2020-11-01 00:00:00
abstract：:We investigated the association between smoking and the disease activity, functional ability, physical mobility, and systemic inflammation in Chinese ankylosing spondylitis (AS) patients. Seventy five male Chinese AS patients in Taiwan were enrolled in the cross-sectional study. These patients fulfilled the 1984 modif...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-013-2165-y
更新日期：2013-05-01 00:00:00
abstract：:Mycoleptodiscus indicus is a recognized plant pathogen which has very rarely been reported as a cause of human infection. It is a tropical or subtropical fungus which is difficult to culture and identify from clinical specimens. This is the first report of septic arthritis with this fungus in a healthy Canadian male. ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-010-1448-9
更新日期：2010-09-01 00:00:00
abstract：:Gonadotropin-releasing hormone (GnRH) is the first key hormone of reproduction. GnRH analogs are extensively used in in vitro fertilization and treatment of sex hormone-dependent cancers due to their ability to bring about 'chemical castration'. Recently it has been showed that it also plays an important role in the m...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-010-1426-2
更新日期：2010-11-01 00:00:00
abstract：INTRODUCTION:Antibody against cyclic citrullinated protein (ACPA) is counted as one of the most important biomarkers in diagnosis, classification, and prognosis of rheumatoid arthritis (RA). We examined the evolution of ACPA during disease course and assess predictive value of time-weighted cumulative ACPA titer on rad...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-019-04554-w
更新日期：2019-09-01 00:00:00
abstract：:We describe the case of a 26-year-old African female who was treated successfully with belimumab in a case of severe membranous lupus nephritis and retinal vasculitis, resistant to first line therapy. She presented initially with chronic dacryoadenitis and screening showed nephrotic-range proteinuria. Biopsy of the ki...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-015-3153-1
更新日期：2016-06-01 00:00:00
abstract：:We report one case of non-Hodgkin lymphoma in a patient, with a 30-year history of rheumatoid arthritis, taking low dose methotrexate weekly over a 10-month period. The mild immunosuppression that occurs with methotrexate therapy probably places patients with rheumatoid arthritis at added risk of developing lymphoprol...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02231567
更新日期：1993-03-01 00:00:00
abstract：:Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a wide range of manifestations and potential to affect several organ systems. Complications arise from both disease and medications especially glucocorticoids, significantly contributing to overall morbidity and mortality. SLE predominantly affect...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-019-04795-9
更新日期：2020-03-01 00:00:00
abstract：:The "A disintegrin and metalloprotease" (ADAM) family is thought to play an important role in tissue destruction and inflammatory reactions. ADAM-17 was first described as the protease responsible for tumor necrosis factor (TNF)-α shedding. Here, we have shown the expression of ADAM-17 in inflammatory myopathy and dem...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-018-4014-5
更新日期：2018-04-01 00:00:00
abstract：:The aim of this study was to ascertain whether fibromyalgia patients with positive ANA develop other features of connective tissue disease over 2-4 years' follow-up. Patients attending our clinic with a diagnosis of fibromyalgia were identified. All ANA-positive patients (n = 12) were recruited and matched for age and...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s100670200118
更新日期：2002-11-01 00:00:00
abstract：:The objectives of the study were to investigate short and long-term changes and relations to treatment response of plasma interleukin-6 (IL-6), vascular endothelial growth factor (VEGF), YKL-40, matrix metalloproteinase-3 (MMP-3), and total aggrecan in patients with spondyloarthritis (SpA) treated with tumor necrosis ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-010-1528-x
更新日期：2010-11-01 00:00:00
abstract：:The aim of this study was to evaluate clinical remission and MDA in PsA patients who started TNF-inhibitors (TNFi) treatment with a 2-year follow-up. Concomitant therapies as well as comorbidities were assessed. Level of concordance of clinimetric indices and the potential predictive factors of remission/MDA were also...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3769-4
更新日期：2017-10-01 00:00:00
