Abstract：
:The "A disintegrin and metalloprotease" (ADAM) family is thought to play an important role in tissue destruction and inflammatory reactions. ADAM-17 was first described as the protease responsible for tumor necrosis factor (TNF)-α shedding. Here, we have shown the expression of ADAM-17 in inflammatory myopathy and demonstrated the role of inflammation in interstitial lung diseases (ILD). ADAM-17 in inflammatory myopathy serum [polymyositis (n = 26), dermatomyositis (n = 34), and clinically amyopathic dermatomyositis (n = 10)] and healthy control (n = 19) was measured using enzyme-linked immunosorbent assay. The relationship between ADAM-17 and clinical data was examined. Finally, we performed immunohistological analysis to investigate the expression of ADAM-17 on the muscles of the inflammatory myopathy patients. ADAM-17 in inflammatory myopathy was significantly higher than that in healthy control (mean ± SEM, 1048 ± 312 and 36 ± 18 pg/ml, respectively; p < 0.05). ADAM-17 in post-treatment with corticosteroid and/or immunosuppressant serum was significantly decreased compared with that in pre-treatment serum (1465 ± 562 and 1059 ± 503 pg/ml, respectively; p < 0.01). ADAM-17 was significantly positively correlated with fractalkine/CX3CL1 and CXCL16. In addition, ADAM-17 in inflammatory myopathy with ILD patients (n = 46) was significantly higher than that in non-ILD patients (n = 24) (1379 ± 454 and 413 ± 226 pg/ml, respectively; p < 0.05). We found the expression of ADAM-17 on muscle biopsy tissue. ADAM-17 is expressed in inflammatory myopathies especially ILD, suggesting that ADAM-17 plays a role in lung fibrosis. ADAM-17 may be a potential target in inflammatory myopathies with ILD.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Nishimi A,Isozaki T,Nishimi S,Ishii S,Tokunaga T,Furuya H,Wakabayashi K,Kasama Tdoi
10.1007/s10067-018-4014-5subject
Has Abstractpub_date
2018-04-01 00:00:00pages
1017-1024issue
4eissn
0770-3198issn
1434-9949pii
10.1007/s10067-018-4014-5journal_volume
37pub_type
杂志文章abstract：:Tissue plasminogen activator (tPA), plasminogen activator inhibitor-1 (PAI-1) and von Willebrand factor (vWF), all of endothelial origin and active in the haemostasis, were analysed in 74 patients with rheumatoid arthritis. The concentrations were related to extra-articular disease and to the incidence of thromboembol...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02231572
更新日期：1993-09-01 00:00:00
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journal_title：Clinical rheumatology
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02031069
更新日期：1989-03-01 00:00:00
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journal_title：Clinical rheumatology
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journal_title：Clinical rheumatology
pub_type： 杂志文章
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更新日期：1986-12-01 00:00:00
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journal_title：Clinical rheumatology
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更新日期：1997-06-01 00:00:00
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更新日期：2020-08-26 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF01452259
更新日期：1998-01-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05017-3
更新日期：2020-09-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
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更新日期：2018-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s10067-017-3590-0
更新日期：2017-05-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：
更新日期：1988-12-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3967-0
更新日期：2018-05-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05253-7
更新日期：2021-02-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF03342643
更新日期：1996-01-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 临床试验,信件
doi：10.1007/s10067-005-1167-9
更新日期：2006-02-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2020-03-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-012-1960-1
更新日期：2012-06-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
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更新日期：2002-11-01 00:00:00
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更新日期：2021-01-15 00:00:00
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pub_type： 杂志文章
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更新日期：2013-04-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 临床试验,杂志文章,多中心研究
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更新日期：1999-01-01 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：2008-01-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
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更新日期：2002-02-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
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更新日期：2015-04-01 00:00:00
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journal_title：Clinical rheumatology
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更新日期：2007-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2018-02-01 00:00:00
