Abstract:
:If rheumatoid arthritis (RA) patients with a mild disease course could be identified early in the phase of the disease, therapy with less aggressive and probably less toxic antirheumatic drugs seems to be rational. The aim of this study was to investigate which factors at baseline could predict a clinical response (American College of Rheumatology preliminary response criteria) after treatment with chloroquine for 16 weeks. Two hundred and three early RA patients with active disease were treated with oral chloroquine sulphate (Nivaquine) at a daily dose of 300 mg during the first 4 weeks, 200 mg during the second 4 weeks and 100 mg thereafter. One hundred and eighty-three patients (90%) completed the study and 20 patients prematurely discontinued treatment. Of all the patients, 43 patients (21%) met the response criteria. A low level of C-reactive protein (CRP) was the only independent predictor for clinical response [relative risk: 0.97 (95% confidence interval: 0.95-0.98)]. It was concluded that a clinical response to chloroquine therapy in early RA patients can be predicted by a low CRP level at baseline.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
van den Borne BE,Landewé RB,Rietveld JH,Goei The HS,Griep EN,Breedveld FC,Dijkmans BAdoi
10.1007/s100670050121subject
Has Abstractpub_date
1999-01-01 00:00:00pages
369-72issue
5eissn
0770-3198issn
1434-9949journal_volume
18pub_type
临床试验,杂志文章,多中心研究abstract::To characterize the distinctive chest high-resolution computerized tomography (HRCT) features and clinical manifestations of primary Sjögren syndrome (pSS)-related interstitial lung disease (ILD). The demographic data, clinical manifestations, and laboratory and radiological findings of 527 pSS patients were retrospec...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4289-6
更新日期:2018-11-01 00:00:00
abstract::Iron-binding proteins (lactoferrin, transferrin and ferritin) and free iron were measured in synovial fluid (SF) from 30 patients with rheumatoid arthritis (RA) and 20 osteoarthritis (OA) patients. The iron-binding proteins except transferrin were significantly increased in RA SF as compared with OA SF. Similarly, fre...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02030347
更新日期:1989-09-01 00:00:00
abstract:OBJECTIVE:To evaluate and compare the diagnostic test accuracy of magnetic resonance imaging (MRI) and ultrasound (US) for bone erosion in rheumatoid arthritis (RA) patients for a specific and efficient diagnostic recommendation. METHOD:To evaluate the diagnostic accuracy, the sensitivity, specificity, area under the ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s10067-019-04825-6
更新日期:2020-04-01 00:00:00
abstract::Behçet's disease is a systemic vasculitic syndrome with unknown etiology. The aim of the present study was to compare the Helicobacter pylori seropositivity and cytotoxin associated gene-A status in patients with Behçet's disease. Ninety-one patients with Behçet's disease and 83 age- and sex-matched persons with or wi...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-006-0416-x
更新日期:2007-06-01 00:00:00
abstract::Antinuclear antibody (ANA) test results frequently affect the course of patients' evaluations, diagnosis, and treatment, but different laboratory centers may yield conflicting results. This study investigated the degree of agreement between laboratory results in a group of subjects who had ANA testing performed at two...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-016-3241-x
更新日期:2016-07-01 00:00:00
abstract::We report two cases of a full-thickness rotator cuff tear followed by acromioclavicular cyst formation in patients with longstanding erosive polyarticular rheumatoid arthritis. One of the consequences of a rotator cuff tear is articular instability with upward migration of the humeral head. The ensuing chronic frictio...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF01452269
更新日期:1998-01-01 00:00:00
abstract::The aim of the study was to assess the eventual presence, cellular localization and extent of expression of the osteoclast activating cytokine M-CSF (CSF-1) in the periprosthetic tissues around loose total hip replacement (THR). Synovial-like membrane was obtained from the implant-to-bone interface and pseudocapsule f...
journal_title:Clinical rheumatology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02238958
更新日期:1997-05-01 00:00:00
abstract::Bone metabolism in patients with rheumatoid arthritis is reviewed. Two different entities are recognised: 1) a localised periarticular bone loss, due to inflammatory processes and 2) a generalised increased bone turnover, ultimately leading to a loss of axial bone mass. The mechanism of this loss of axial bone is not ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/BF02284051
更新日期:1988-03-01 00:00:00
abstract::A 45-year-old patient is described presenting with severe axial osteoporosis. The presence of maculopapular skin lesions and the combination of osteolytic and osteoblastic bone lesions led to the tentative diagnosis of systemic mastocytosis. This diagnosis was confirmed by measurement of urinary histamine metabolites ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02206850
更新日期:1987-09-01 00:00:00
abstract::The aim of this study was to describe a single-center experience in the treatment and follow-up of cystoid macular edema patients. Clinical records of all patients with cystoid macular edema followed up in the Rheumatologic and Ophthalmological Unit of our center between 1993 and 2013 were retrospectively evaluated. T...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-014-2694-z
更新日期:2015-04-01 00:00:00
abstract::Current Canadian osteoporosis guidelines recommend routine bone density screening of men at age 65. The purpose of this study is to determine the prevalence of osteoporosis in men aged 65-75 in after application of screening guidelines. All males aged 65-75 years who attended a large primary care clinic were advised o...
journal_title:Clinical rheumatology
pub_type: 杂志文章,多中心研究
doi:10.1007/s10067-014-2642-y
更新日期:2015-03-01 00:00:00
abstract::Idiopathic Inflammatory myopathies (IIM) are rare disorders. The aim of our study was to determine the incidence of IIM in a well-defined Slovenian region. This retrospective study was conducted at the Department of Rheumatology, University Medical Centre Ljubljana, the only secondary/tertiary rheumatology center in a...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4237-5
更新日期:2019-02-01 00:00:00
abstract::We investigated the all-inclusive echocardiographic features in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) within 3 months before and after diagnosis. We reviewed the medical records of 89 AAV patients taking echocardiography and 35 age- and gender-matched controls. We collect...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3868-2
更新日期:2017-12-01 00:00:00
abstract::rs2431697 is located on 5q33.3, between pituitary tumor-transforming gene 1 and miR-146a. Several studies have estimated the association between rs2431697 and systemic lupus erythematosus risk. However, the results were inconsistent. A case-control study was carried out to explore the association between rs2431697 and...
journal_title:Clinical rheumatology
pub_type: 杂志文章,meta分析
doi:10.1007/s10067-015-3045-4
更新日期:2015-11-01 00:00:00
abstract::Efficacy of hip protector pads to prevent hip fracture is controversial. This study was done to evaluate two comparable groups for fracture risk. Two matched cohorts of long-term care residents in Canada, assessing the efficacy of hip protector pads. Evaluation included demographics, medications/diagnoses, cognition (...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-009-1115-1
更新日期:2009-06-01 00:00:00
abstract::The aim of this study was to analyse microvascular damage and compensatory angiogenesis in skin from patients with systemic sclerosis (SSc) compared with systemic lupus erythematosus (SLE), Raynaud's phenomenon (RP) and healthy controls. Immunohistochemistry was used for skin biopsies (9 SSc, 10 SLE, 9 RP and 12 healt...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-003-0698-1
更新日期:2003-09-01 00:00:00
abstract::Delayed diagnosis in patients with Churg-Strauss syndrome (CSS) is largely attributed to the variable and nonspecific presentation of the disease's initial symptoms. The aim of the study was to evaluate the effect of delayed diagnosis on the course of CSS. We conducted a retrospective study of 30 CSS patients followed...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-012-2127-9
更新日期:2013-03-01 00:00:00
abstract::The cellular localization of the Ro/SS-A antigen was defined using indirect immunofluorescence and eight monospecific anti- Ro/SS-A antisera which were identified by immunoblotting. Several mammalian tissues were used as substrates. The Ro/SS-A antigen was located mainly in the nucleus of dog liver and Hep-2-cells, an...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02030965
更新日期:1986-01-01 00:00:00
abstract::Since diffuse idiopathic skeletal hyperostosis (DISH) is frequently difficult to differentiate radiologically from the axial involvement of ankylosing spondylitis and osteoarthrosis, some features of these 3 different diseases were compared. The predominantly horizontal nature of the enthesiophyte in DISH and its righ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02283118
更新日期:1992-12-01 00:00:00
abstract::The aim of this study was to evaluate clinical remission and MDA in PsA patients who started TNF-inhibitors (TNFi) treatment with a 2-year follow-up. Concomitant therapies as well as comorbidities were assessed. Level of concordance of clinimetric indices and the potential predictive factors of remission/MDA were also...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3769-4
更新日期:2017-10-01 00:00:00
abstract::The aim of this study is to describe the clinical features of Lebanese patients with Behçet's disease (BD) followed up at a tertiary care center in Lebanon. A retrospective review of medical records of 90 patients who fulfilled the International Study Group (ISG) criteria for diagnosis was performed. The clinical char...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-005-0058-4
更新日期:2006-05-01 00:00:00
abstract:INTRODUCTION/OBJECTIVES:The primary objective was to evaluate the impact of an in-department pharmacist on the prevention of drug iatrogenesis in a rheumatology department. Secondary objectives were to determine (i) if medication history discrepancies were detected more frequently in the elderly or not, and (ii) if the...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05138-9
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVES:High levels of serum uric acid (UA) are associated with cerebro-cardiovascular disease risk factors. This study aimed at evaluating the main determinants of serum UA levels in relation to biochemical, lifestyle, and clinical variables. METHODS:The study population included 15,594 participants (48% men, age ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05288-w
更新日期:2020-07-16 00:00:00
abstract::The original version of this article was revised due to a retrospective Open Access order. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,已发布勘误
doi:10.1007/s10067-020-05278-y
更新日期:2020-10-01 00:00:00
abstract::To analyze fucosylation of alpha(1)-acid glycoprotein (AGP) and to identify relations between AGP fucosylation and clinical and biochemical indices of disease activity in patients with rheumatoid arthritis (RA) treated with monoclonal antitumor necrosis factor (TNF) antibody infliximab, we examined 22 patients with RA...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-007-0572-7
更新日期:2007-10-01 00:00:00
abstract::We report a 29-year-old Japanese woman with disseminated intravascular coagulation (DIC) and adult onset Still's disease (AOSD). Her disease was refractory to high-dose glucocorticoids, two courses of steroid pulse therapy, and addition of cyclosporine (3.5 mg/kg/day). The serum interleukin-6 level was markedly elevat...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-009-1097-z
更新日期:2009-04-01 00:00:00
abstract::A 71-year-old male rheumatoid patient presented with MRSA septic arthritis. The impact of this organism on musculoskeletal practice is discussed. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF01450904
更新日期:1998-01-01 00:00:00
abstract::Autonomic nervous system (ANS) involvement has been studied in systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, Sjogren's syndrome, and ankylosing spondylitis but still has not been studied in psoriatic arthritis (PsA). The aim of this study was to investigate the prevalence and the nature of au...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-013-2239-x
更新日期:2013-07-01 00:00:00
abstract::Progressive systemic sclerosis (PSS) is a connective tissue disease that may affect many organs, including the kidneys. It is quite rare to see secondary amyloidosis due to PSS. We present a patient with a 9-year history of PSS who developed nephrotic syndrome, and whose renal biopsy was compatible with secondary amyl...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670170048
更新日期:2001-01-01 00:00:00
abstract::We report a case of bleomycin-induced scleroderma in a 35-year-old woman treated with chemotherapy for Hodgkin's disease. Approximately 6 months after the first chemotherapy cycle, the patient developed skin sclerosis in both arms. The lesion showed no signs of spontaneous clinical amelioration and treatment with ster...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670050131
更新日期:1999-01-01 00:00:00