Abstract：
:We report a 29-year-old Japanese woman with disseminated intravascular coagulation (DIC) and adult onset Still's disease (AOSD). Her disease was refractory to high-dose glucocorticoids, two courses of steroid pulse therapy, and addition of cyclosporine (3.5 mg/kg/day). The serum interleukin-6 level was markedly elevated. Therefore, we administered an anti-interleukin-6 receptor antibody (tocilizumab, 8 mg/kg fortnightly), which dramatically improved her symptoms and the levels of acute-phase proteins. In addition, rapid tapering of the glucocorticoid dose was possible. Four months later, she was maintained on tocilizumab infusion once a month with low-dose steroid therapy. Cyclosporine is one of the first-line immunosuppressants for AOSD, especially when associated with DIC, hepatic failure, or hemophagocytic syndrome. In patients with cyclosporine-resistant AOSD, tocilizumab may be another useful option.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Matsumoto K,Nagashima T,Takatori S,Kawahara Y,Yagi M,Iwamoto M,Okazaki H,Minota Sdoi
10.1007/s10067-009-1097-zsubject
Has Abstractpub_date
2009-04-01 00:00:00pages
485-7issue
4eissn
0770-3198issn
1434-9949journal_volume
28pub_type
杂志文章abstract：:The level of the N terminal fragment of procollagen III (P3NP) levels of 100 consecutive patients affected by rheumatoid arthritis (RA) were evaluated in comparison with disease activity markers (erythrocytes sedimentation rate, C reactive protein), immunological status (rheumatoid factors, immune complexes) and joint...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02283106
更新日期：1992-12-01 00:00:00
abstract：:The purpose of this report is to describe the overall safety profile of both short- and longer-term duloxetine treatment of fibromyalgia. Data from four double-blind, randomized, placebo-controlled studies (two with 6-month open-label extension phases) and a 1-year, open-label safety study were included. Safety measur...
journal_title：Clinical rheumatology
pub_type： 杂志文章,meta分析
doi：10.1007/s10067-009-1203-2
更新日期：2009-09-01 00:00:00
abstract：:The authors describe an atypical case of a patient having giant cell arteritis presenting only with fever, diagnosed by positron emission tomography and subsequently confirmed by temporal artery biopsy. ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-007-0831-7
更新日期：2008-06-01 00:00:00
abstract：:Pulse prednisolone hemisuccinate therapy (500 mg given intravenously on three occasions over two weeks) has been combined with either intramuscular sodium aurothiomalate or azathioprine in an assessment of 30 patients with rheumatoid arthritis. Significant improvement in a variety of clinical and biochemical assessmen...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02204452
更新日期：1988-06-01 00:00:00
abstract：:Calcinosis, Raynaud's phenomenon, oesophageal dysmotility, sclerodactyly, telangiectasia (CREST) syndrome, a limited form of systemic sclerosis, is sometimes complicated by primary biliary cirrhosis (PBC). A 52- and 61-year-old Japanese woman with PBC-CREST overlap syndrome accompanied by Sjögren's syndrome, and Hashi...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-005-0178-x
更新日期：2007-04-01 00:00:00
abstract：:Microwave thermography is the technique of measuring natural thermal radiation from body tissues of clinical interest. It is safe, requires no control of environmental conditions and exposes the patient to no ionising radiation. In this study, we found that microwave thermography of the knee joints showed weak correla...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02242999
更新日期：1994-12-01 00:00:00
abstract：:We report a case of bleomycin-induced scleroderma in a 35-year-old woman treated with chemotherapy for Hodgkin's disease. Approximately 6 months after the first chemotherapy cycle, the patient developed skin sclerosis in both arms. The lesion showed no signs of spontaneous clinical amelioration and treatment with ster...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s100670050131
更新日期：1999-01-01 00:00:00
abstract：:Knee osteoarthritis (KOA) is a common degenerative joint disease causing pain, stiffness, reduced motion, swelling, crepitus, and disability. Several inflammatory markers and cartilage degradation products can be used as biomarkers in OA. The key factors of bone metabolism in normal joint bone, dickkopf-1 (DKK1) and o...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3690-x
更新日期：2017-10-01 00:00:00
abstract：:The objectives of the study were to investigate short and long-term changes and relations to treatment response of plasma interleukin-6 (IL-6), vascular endothelial growth factor (VEGF), YKL-40, matrix metalloproteinase-3 (MMP-3), and total aggrecan in patients with spondyloarthritis (SpA) treated with tumor necrosis ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-010-1528-x
更新日期：2010-11-01 00:00:00
abstract：:The objective of this study was to understand the patient experience of musculoskeletal imaging tests for investigation of inflammatory arthritis and factors that contribute to this experience. We conducted a thematic analysis of semi-structured interviews with 33 patients who had a recent peripheral joint musculoskel...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3760-0
更新日期：2018-08-01 00:00:00
abstract：:We investigated the occurrence of an active cytomegalovirus (CMV) infection in patients with polyarteritis nodosa (PAN). Eleven patients with PAN were screened for the presence of CMV-DNA in their blood using the polymerase chain reaction (PCR). Serum anti-CMV IgG and anti-CMV IgM antibodies were determined by enzyme-...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s100670050148
更新日期：1999-01-01 00:00:00
abstract：:Acute gouty arthritis (AGA) is an auto-inflammatory disease characterized by resolving spontaneously, which suggests that negative feedback loops control inflammatory and immunological responses to monosodium urate (MSU) crystals. By now, the molecular mechanism for spontaneous resolution of acute GA remains unclear; ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-015-3109-5
更新日期：2016-09-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:ABP 798 is a proposed biosimilar to the originator biologic rituximab, an anti-CD20 monoclonal antibody. This comparative clinical study evaluated the pharmacokinetics (PK), safety, and efficacy of ABP 798 versus rituximab reference product (RP) in patients with moderate-to-severe rheumatoid arthr...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05305-y
更新日期：2020-11-01 00:00:00
abstract：:The objective of this study was to characterise the peripheral arthritis of spondyloarthritis (pSpA) excluding psoriatic-, inflammatory enteropathy-related, post-infectious reactive-SpA and arthritis associated with axial SpA/ankylosing spondylitis (axSpA/AS). Patients presenting with the clinical features of the broa...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3720-8
更新日期：2017-11-01 00:00:00
abstract：:Two cases of late hypophosphatemic osteomalacia are described: a male aged 30 who had the disease since he was 22 and a woman of 23 who had the disease since she was 14. Both presented with myopathy and bone pain, and showed hypophosphatemia, hyperglycinuria, reduced tubular phosphate reabsorption (TPR), increased hyd...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02031617
更新日期：1985-09-01 00:00:00
abstract：:We investigated, in retrospect, if there were differences in the frequency and types of abdominal surgery between newly diagnosed female fibromyalgia (n = 80) and rheumatoid arthritis (n = 47) patients performed before the formal diagnosis. There was no difference in the total number of abdominal operations between bo...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s100670050042
更新日期：1999-01-01 00:00:00
abstract：:To examine the relationship between physical appearance concern and psychological distress in female adolescent patients with systemic lupus erythematosus (SLE) was the aim of this study. A total of 84 adolescent SLE female patients and 80 age-matching healthy adolescents were evaluated for levels of appearance concer...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-012-2071-8
更新日期：2012-12-01 00:00:00
abstract：:The tendency of patients with DISH towards obesity or an adult onset of diabetes has been reflected in marked hyperinsulinaemia following glucose challenge. It is hypothesized that insulin at prolonged and high physiologic levels promotes new bone growth, particularly in the entheseal regions. These areas are also sub...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02031611
更新日期：1985-09-01 00:00:00
abstract：:This article is a small case series that aims to discuss the impact of depression, vascular, and fibrotic changes on development of erectile dysfunction (ED) in patients with systemic sclerosis (SSc). In this paper, we present five male patients with SSc, aged 30-48 years. All patients are nonsmokers, and their past m...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-007-0567-4
更新日期：2007-10-01 00:00:00
abstract：:The relations between parameters obtained by clinical absorptiometric techniques, such as SPA, DPA, DXA and QCT, and geometrical and material parameters of bone structures are investigated. Two types of bone are considered: the diaphysis of a long bone, modelled as a hollow cylindrical structure consisting of compact ...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：
更新日期：1994-12-01 00:00:00
abstract：:We studied the serum levels of B cell survival factors BAFF and APRIL in patients with idiopathic inflammatory myositis (IIM) and their relation with clinical and autoantibodies. Seventy-five patients (51 females and 24 males) with IIM (Bohan and Peter's criteria 1975) and 25 healthy adults were analyzed for BAFF, APR...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-018-4046-x
更新日期：2018-05-01 00:00:00
abstract：OBJECTIVE:To identify factors associated with active tuberculosis (TB) in patients with systemic lupus erythematosus (SLE). METHODS:We performed a retrospective case-control study in two tertiary care teaching hospitals in Medellín, Colombia. From January 2007 to December 2017, a total of 268 patients with SLE were in...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05225-x
更新日期：2021-01-01 00:00:00
abstract：:In the study of pathophysiological mechanisms in growth abnormalities of the juvenile knee in arthritis an animal model in dogs was developed. Arthritis was induced by intra-articular injections of Carrageenan. Prominent growth changes were enlargement of the distal femoral epiphysis, patellar squaring and decreased e...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02030752
更新日期：1984-06-01 00:00:00
abstract：:Adiponectin is a hormone released by adipose tissue with antidiabetic, antiatherogenic, and anti-inflammatory properties. The present observational study focused on the relation between serum adiponectin level and the disease severity of established rheumatoid arthritis (RA). Ninety patients with more than 5-year diag...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-008-1074-y
更新日期：2009-04-01 00:00:00
abstract：:The acute renal side-effects of nonsteroidal anti-inflammatory drugs are well documented. These include interstitial nephritis, hyperkalaemia, renal tubular acidosis, fluid retention, hypertension and nephrotic syndrome. The long-term effects are less well known. We have carried out a cross-sectional survey of an unse...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02204466
更新日期：1988-06-01 00:00:00
abstract：:We report three cases of tricho-rhino-phalangeal syndrome (TRPS) type I in a Belgian family. They presented typical characteristics such as a pear-shaped nose, and short, deformed fingers with cone-shaped epiphyses of some middle phalanges of the hands. Hair growth was practically normal in our patients, except for so...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02201022
更新日期：1987-06-01 00:00:00
abstract：:There is an increasing concern over generalizability of trial results. We investigated eligibility criteria of knee osteoarthritis clinical trials. Eligible trials were randomized, placebo-controlled trials that were identified by searches in MEDLINE, SCOPUS, and the Cochrane Central Register of Controlled Trials. We ...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-013-2342-z
更新日期：2013-11-01 00:00:00
abstract：:The presence of nail changes was investigated in 102 patients with nodal osteoarthritis of the hand. Nail lesions were seen in 14/102 patients (13.7%), a prevalence higher than that observed in 96 controls (4/96, 4.2%; chi square 4.37, p = 0.036). An increased risk of nail changes was associated with osteoarthritis of...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02249013
更新日期：1994-06-01 00:00:00
abstract：:The signalling lymphocyte activation molecule (SLAM) family receptors play important roles in modulating immune responses. Previous studies in murine models and patients have suggested an association of the SLAM family (SLAMF) members with the development of autoimmunity, particularly systemic lupus erythematosus (SLE...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3698-2
更新日期：2018-03-01 00:00:00
abstract：:A possible role of tumor necrosis factor alpha (TNFalpha) in the pathomechanism of sarcoidosis must be considered in the analysis of this disorder since elevated concentrations of this cytokine have been found. In addition, TNFalpha expression could be demonstrated in sarcoid granulomata [1]. It is well known that TNF...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-005-0037-9
更新日期：2006-07-01 00:00:00
