Brief report: Decreased expression of CD244 (SLAMF4) on monocytes and platelets in patients with systemic lupus erythematosus.

Abstract:

:The signalling lymphocyte activation molecule (SLAM) family receptors play important roles in modulating immune responses. Previous studies in murine models and patients have suggested an association of the SLAM family (SLAMF) members with the development of autoimmunity, particularly systemic lupus erythematosus (SLE). Since previous investigations on CD244 expression have focussed on NK and T cells, the aim of this study was to evaluate the surface expression of major SLAMF members across monocytes and polymorphonuclear cells in an Asian SLE cohort and explore their potential associations with SLE-related disease activity and autoantibodies. Thirty-nine SLE patients and twenty-nine healthy controls (HC) were evaluated for the expression of CD150, CD84, CD229, CD48, CD244, CD352 and CD319. We determined a significantly lower expression of CD244 on monocytes in SLE patients compared to HC. Furthermore, monocyte CD244 expression was negatively associated with several serum autoantibody titres. Our findings suggest that this molecule plays an important role in immune tolerance mechanisms and should be investigated further.

journal_name

Clin Rheumatol

journal_title

Clinical rheumatology

authors

Mak A,Thornhill SI,Lee HY,Lee B,Poidinger M,Connolly JE,Fairhurst AM

doi

10.1007/s10067-017-3698-2

subject

Has Abstract

pub_date

2018-03-01 00:00:00

pages

811-816

issue

3

eissn

0770-3198

issn

1434-9949

pii

10.1007/s10067-017-3698-2

journal_volume

37

pub_type

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