Abstract：
:There is an increasing concern over generalizability of trial results. We investigated eligibility criteria of knee osteoarthritis clinical trials. Eligible trials were randomized, placebo-controlled trials that were identified by searches in MEDLINE, SCOPUS, and the Cochrane Central Register of Controlled Trials. We then attempted to extract data on the eligibility criteria by employing predetermined criteria. From 355 randomized knee osteoarthritis trials, we reviewed data categorized by non-osteoarthritis-related and osteoarthritis-related factors. A variety of items were used in the eligibility criteria. Regarding the non-osteoarthritis-related factors, ethical considerations, such as inability to give an informed consent (79.4 %) or medical conditions potential for risks by test treatments (56.0 %) or by participation in a trial (57.2 %), were the common reasons for excluding patients from a trial. Concerning the osteoarthritis-related factors, most of the trials did not specify age and symptom severity. When trials specifying these items were investigated, patients with 40 to 80 years in age and grade 2 in the Kellgren-Lawrence scale were mostly included into a trial. For the pain intensity, patients with ≥20-40 in the 100-mm visual analog scale and ≥6-8 in the WOMAC pain subscale were commonly enrolled into a trial. These findings warrant further investigation on the generalizability of trial results.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Koog YH,Wi H,Jung WYdoi
10.1007/s10067-013-2342-zsubject
Has Abstractpub_date
2013-11-01 00:00:00pages
1569-74issue
11eissn
0770-3198issn
1434-9949journal_volume
32pub_type
杂志文章,评审abstract：:A pair of identical twins suffering from ankylosing spondylitis is reported. One brother developed an earlier-onset disease and showed ossification of the posterior longitudinal ligament and the flavum ligament in his cervical spine. ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02249033
更新日期：1994-06-01 00:00:00
abstract：:Recently, the Ankylosing Spondylitis Disease Activity Score (ASDAS), a new index, has been shown to be validated and highly discriminatory in assessing ankylosing spondylitis (AS) disease activity. This study is to evaluate the performance of ASDAS in a local Chinese cohort of AS in a cross-sectional setting and to co...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-014-2729-5
更新日期：2014-08-01 00:00:00
abstract：:In sera of patients with systemic lupus erythematosus (SLE) a wide variety of antibodies against nuclear antigens can be found, including antibodies to nucleic acids, histones and non-histone nuclear proteins. Among these, antibodies to double stranded DNA (dsDNA) appear to be mainly restricted to SLE. Yet, in daily p...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/BF02200721
更新日期：1987-06-01 00:00:00
abstract：:To describe clinical and epidemiological data of Behçet's disease (BD) in Brazil, we retrospectively reviewed records of all patients seen between 2006 and 2007 at the BD outpatient clinic of University of Sao Paulo. One hundred and six patients fulfilled the International Study Group for Behçet's Disease diagnostic c...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-008-1081-z
更新日期：2009-05-01 00:00:00
abstract：:The objective of this study was to analyze the clinical, laboratorial, and therapeutical response of polymyalgia rheumatica (PMR) to anti-tumor necrosis factor (anti-TNF) treatment. We systematically searched English articles on the subjects of PMR who were treated with TNF blockers in Pubmed from 1994 to 2010. In add...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-011-1914-z
更新日期：2012-03-01 00:00:00
abstract：:The aim of the is study is to examine the role of serum substance P (SP) levels as a simple biomarker for rheumatoid arthritis (RA) disease activity, its correlation with other markers of disease activity, and with selected clinical parameters. The study comprised 90 RA patients and 24 healthy controls. RA activity wa...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3929-6
更新日期：2018-04-01 00:00:00
abstract：INTRODUCTION:Studies conducted by various scientific societies have shown that the demand for specialized rheumatology care is greater than the projected growth of the workforce. Our research aims to assess the current status of the rheumatology workforce in Latin America. METHOD:This is a descriptive, cross-sectional...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05555-w
更新日期：2021-01-15 00:00:00
abstract：:This study was designed to investigate the functional heterogeneity of human Th17 and how their plasticity shapes the nature of immune cell responses to inflammation and autoimmune diseases, such as systemic lupus erythematosus (SLE). We evaluated functional Th17 cell subsets based on the profile of cytokine productio...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-011-1860-9
更新日期：2012-03-01 00:00:00
abstract：:We investigated the clinical characteristics, management modalities, and outcomes in patients with relapsing polychondritis (RP) with airway involvement. The medical records of RP patients with airway involvement seen at Samsung Medical Center from August 2004 to December 2011 were collected. The clinical manifestatio...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-013-2279-2
更新日期：2013-09-01 00:00:00
abstract：OBJECTIVE:To explore the trends in diagnosis of Kawasaki disease (KD) and determine the characteristics for patients outside the usual age range of 6 months to 4 years. METHOD:A retrospective review of patients with KD identified in four epidemiological surveys spanning 20 years (1998-2017) in Shanghai was performed. ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05361-4
更新日期：2020-08-26 00:00:00
abstract：:Children with juvenile idiopathic arthritis (JIA) may infrequently present with localized anterior knee pain or swelling, in addition to generalize knee pain induced by JIA. We report five cases of deep infrapatellar bursitis in children with JIA. The clinical features, radiological findings, management, and outcome o...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-010-1620-2
更新日期：2011-02-01 00:00:00
abstract：:The objectives of this paper are to evaluate the efficacy of a community-based lay-led Arthritis Self-Management Program (ASMP) among patients with chronic inflammatory arthritis and evaluate the effectiveness of "shared care collaboration" between hospital and community. We trained 17 lay leaders and recruited patien...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-014-2791-z
更新日期：2016-04-01 00:00:00
abstract：:Idiopathic paroxysmal rhabdomyolysis indicating a classical triad of symptoms consisting of muscle pain, weakness, and discolored urine is known as "Meyer-Betz syndrome". It may result in acute renal failure due to precipitation of the myoglobin casts in the tubuli or to the direct toxic effects of myoglobin to the tu...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-005-0091-3
更新日期：2006-11-01 00:00:00
abstract：:Intercellular adhesion molecule-1 (ICAM-1) is a membrane bound molecule that plays an important role in the pathogenic inflammatory responses observed in vasculitis. The aim of this study was to determine whether levels of soluble ICAM-1 sICAM-1) shedding into the circulation reflect the vascular injury found in nailf...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02230359
更新日期：1996-07-01 00:00:00
abstract：:We aimed to evaluate the presence of peripheral antineutrophil cytoplasmic antibodies (p-ANCA) and cytoplasmic antineutrophil cytoplasmic antibodies (c-ANCA) in children with SLE and to correlate its association of laboratory findings. Twenty-one children with SLE were studied. Serum samples in patients were tested by...
journal_title：Clinical rheumatology
pub_type： 临床试验,杂志文章
doi：10.1007/BF01451065
更新日期：1998-01-01 00:00:00
abstract：:There are few reports about the coexistence of Sjögren's syndrome (SS) and ankylosing spondylitis (AS). To evaluate the frequency of SS in patients with AS. We studied 70 patients with AS presenting to the university outpatient clinic between January 2002 and November 2003. All the patients were asked about sicca symp...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-006-0255-9
更新日期：2007-02-01 00:00:00
abstract：:The aim of this study was to evaluate the long-term efficacy and safety of single or 1-3 weekly injections of hylan G-F 20 at 1 year following the first injection for knee osteoarthritis (OA). Searches were conducted in PubMed/MEDLINE, Embase, and CENTRAL and included relevant conference proceedings (January 1, 1995-A...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-020-05477-7
更新日期：2020-10-27 00:00:00
abstract：:To analyze fucosylation of alpha(1)-acid glycoprotein (AGP) and to identify relations between AGP fucosylation and clinical and biochemical indices of disease activity in patients with rheumatoid arthritis (RA) treated with monoclonal antitumor necrosis factor (TNF) antibody infliximab, we examined 22 patients with RA...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-007-0572-7
更新日期：2007-10-01 00:00:00
abstract：:The ACR/EULAR Boolean remission criteria for rheumatoid arthritis (RA) include a strict cutoff for patient global assessment (PGA, value ≤ 1/10). Near-remission corresponds to remission for joint counts and C-reactive protein but with PGA > 1. The objective was to explore whether the contribution of PGA to remission a...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-018-3998-1
更新日期：2018-06-01 00:00:00
abstract：:The higher incidence of arterial and venous events is well established in patients with rheumatoid arthritis (RA). Our aim here was to investigate whether there is a prothrombotic state in RA patients by using rotational thromboelastometry (ROTEM) method and to demonstrate whether the disease variables play a role in ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-018-4134-y
更新日期：2018-09-01 00:00:00
abstract：:The swift and accurate diagnosis of acute arterial occlusion and limb ischemia is critical to prevent morbidity from this vascular emergency as reported by Bettman et al. (Radiology 215:101-105, 2000). There are a number of imaging modalities available to the diagnosing physician. However, the most appropriate modalit...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-010-1419-1
更新日期：2013-03-01 00:00:00
abstract：:We report a case of a 53-year-old woman diagnosed of systemic sclerosis. She underwent an episode of pulmonary haemorrhage, characterized by haemoptysis, sudden anaemization, and bilateral alveolar infiltration during her hospitalization, which was resolved with steroid treatment. Subsequently, she developed a focal n...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/BF02207098
更新日期：1992-03-01 00:00:00
abstract：OBJECTIVES:Rheumatoid arthritis (RA) may increase the risk of anxiety, but results from prior studies have no consensus. Our study aimed to evaluate the relationship between RA and incident anxiety by using a quantitative meta-analysis. METHODS:A number of databases were used to gather relevant information; they inclu...
journal_title：Clinical rheumatology
pub_type： 杂志文章,meta分析
doi：10.1007/s10067-019-04502-8
更新日期：2019-08-01 00:00:00
abstract：:Hepatitis C-associated osteosclerosis (HCAO) is an impressive example of acquired diffuse osteosclerosis in adults, recently described in ten patients infected with hepatitis C virus (HCV). Its hallmark is a painful and generalized increase of bone mass. Bone biopsies show enhanced accretion rate, usually without hist...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-004-1031-3
更新日期：2005-06-01 00:00:00
abstract：:We encountered only three patients of carpal tunnel syndrome (CTS) due to tophaceous gout during 25 years of practice in a 'hand clinic' situated in a large metropolis in West India. In two patients, the CTS was bilateral, a rare occurrence in gout. There was an unwarranted delay (up to 9 years) in the diagnosis of bo...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-007-0672-4
更新日期：2007-12-01 00:00:00
abstract：:Sixty-one Thai patients with ankylosing spondylitis (AS), diagnosed in accordance with Rome and New York criteria for AS, were studied. The cases includes idiopathic AS (46 cases), Reiter's syndrome AS (8 cases) and psoriatic spondylitis (7 cases). The vast majority of patients were male (Male:Female = 11.2:1), and in...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02032322
更新日期：1985-03-01 00:00:00
abstract：:Forty-four patients with typical palindromic rheumatism were typed for HLA-A,B,C and DR antigens. The mean duration of follow-up of our patients was 4.0 yrs. (range 1-12 yrs.). During this time 27% of patients showed a seropositivity; 22% of patients developed polyarthritis, 1 patient revealed a Sjögren syndrome and 3...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：
更新日期：1988-12-01 00:00:00
abstract：:The aim of this study was to analyse microvascular damage and compensatory angiogenesis in skin from patients with systemic sclerosis (SSc) compared with systemic lupus erythematosus (SLE), Raynaud's phenomenon (RP) and healthy controls. Immunohistochemistry was used for skin biopsies (9 SSc, 10 SLE, 9 RP and 12 healt...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-003-0698-1
更新日期：2003-09-01 00:00:00
abstract：:CD30/CD30L and CD40/CD40L are molecules from the tumor necrosis factor (TNF) superfamily. They have a major effect on communications between the B and T cells, which leads to control of maturation, proliferation, and apoptosis of those cells. The aim of this study was to compare the levels of a soluble form of CD30 (s...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-006-0389-9
更新日期：2007-05-01 00:00:00
abstract：:Tumour necrosis factor alpha (TNF alpha) and interleukin-2 (IL-2) are potential immunological mediators of pathogenetic changes in rheumatoid arthritis. We measured the concentrations of TNF alpha and IL-2 in plasma from 2 groups of patients suffering from rheumatoid arthritis (RA). One group had high and one had low ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02206655
更新日期：1991-12-01 00:00:00
