Serum N terminal procollagen III fragment: a predictive marker of joint destruction in rheumatoid arthritis?

Abstract:

:The level of the N terminal fragment of procollagen III (P3NP) levels of 100 consecutive patients affected by rheumatoid arthritis (RA) were evaluated in comparison with disease activity markers (erythrocytes sedimentation rate, C reactive protein), immunological status (rheumatoid factors, immune complexes) and joint destruction (assessed according to the Steinbrocker index). P3NP levels showed no significant relationship either to disease activity or to immunological status; however, a strong association was fond between X-ray grade and P3NP values. A two-year retrospective study of 32 patients belonging to the original 100 patient population allowed us to assign a predictive value for joint destruction to the P3NP level in the early stage of the disease.

journal_name

Clin Rheumatol

journal_title

Clinical rheumatology

authors

Tebib JG,Viguier P,Noel E,Colson F,Barbier Y,Bouvier M

doi

10.1007/BF02283106

subject

Has Abstract

pub_date

1992-12-01 00:00:00

pages

502-7

issue

4

eissn

0770-3198

issn

1434-9949

journal_volume

11

pub_type

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