Abstract:
:The acute renal side-effects of nonsteroidal anti-inflammatory drugs are well documented. These include interstitial nephritis, hyperkalaemia, renal tubular acidosis, fluid retention, hypertension and nephrotic syndrome. The long-term effects are less well known. We have carried out a cross-sectional survey of an unselected out-patient population with definite or classical rheumatoid arthritis to determine the prevalence of renal problems in this group. Thirty-four patients (20%) were shown to have an abnormality as defined by our criteria but in the majority this was transient or had been previously recognised. Thirteen patients (8%) had a persistent unexplained abnormality but only 1 had merited renal biopsy using established criteria (Patient 1). We conclude that the long-term use of NSAID's is associated with relatively few renal side-effects.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Richards IM,Fraser SM,Capell HA,Fox JG,Boulton-Jones JMdoi
10.1007/BF02204466subject
Has Abstractpub_date
1988-06-01 00:00:00pages
267-71issue
2eissn
0770-3198issn
1434-9949journal_volume
7pub_type
杂志文章abstract::The objective of the study was to analyze the impact of TNF antagonists (TNFa) on the total cholesterol and triglycerides on ankylosing spondylitis (AS) and psoriatic arthritis (PsA). In this single-centre observational study of AS and PsA patients, differences in triglyceride and total cholesterol levels and frequenc...
journal_title:Clinical rheumatology
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journal_title:Clinical rheumatology
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pub_type: 临床试验,杂志文章
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02031978
更新日期:1990-06-01 00:00:00
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更新日期:2017-07-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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