Urine macrophage migration inhibitory factor in pediatric systemic lupus erythematosus.

Abstract:

:We reported a series of ten patients with lupus nephritis (five patients in the relapse phase and five in the remission phase) and measured the macrophage migration inhibitory factor (MIF), an important pro-inflammatory cytokine with probable role in the pathogenesis of many inflammatory diseases, in their urine samples. MIF/creatinine (Cr) ratio directly correlated with disease activity and it does not have any significant difference between inactive disease and normal ones. We found that the urine MIF/Cr ratio not only differentiates active disease from inactive disease and normal ones but also correlates with the activity indices of renal pathology.

journal_name

Clin Rheumatol

journal_title

Clinical rheumatology

authors

Otukesh H,Chalian M,Hoseini R,Chalian H,Hooman N,Bedayat A,Yazdi RS,Sabaghi S,Mahdavi S

doi

10.1007/s10067-007-0632-z

subject

Has Abstract

pub_date

2007-12-01 00:00:00

pages

2105-2107

issue

12

eissn

0770-3198

issn

1434-9949

pii

10.1007/s10067-007-0632-z

journal_volume

26

pub_type

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