Abstract：
:Systemic lupus erythematosus (SLE) is a complex autoimmune disease affecting multiple organs/systems with variable activities. We performed a retrospective study to investigate the relationship of clinical characteristics and complications with SLE activity in Chinese Han population. A cohort of 1,490 SLE inpatients was evaluated for disease activity using the systemic lupus erythematosus disease activity index (SLEDAI). Chi-square test or Fisher's exact test was used to compare differences of clinical and laboratory features between active and inactive SLE patients. Logistic regression was chosen to explore the pattern of risk factors for disease activity. We found that neuropsychiatric involvement, nephritis, arthralgia, anti-dsDNA, serositis, hypocomplementemia, oral ulcerations, erythrocyte sedimentation rate, low C3, hematological abnormalities, and systolic pressure (1.010 < odds ratio < 10.568, 1.002 < 95% confidence interval < 31.599, 0.000 < P < 0.026) were major factors associated with disease activity, but not headaches, anti-ribonucleoprotein or anti-Sm, C-reactive protein, and anemia (P > 0.05, respectively). The involvements of urinary system, respiratory system, and central nervous system were significantly more frequent in active SLE than inactive SLE (0.000 < P < 0.014), except for alimentary system (P = 0.399). Our study has comprehensively evaluated the relationship of clinical characteristics and organs/systems involvement of SLE with SLEDAI in Chinese Han population and presented a compendium of factors affecting SLE, which should be useful for better evaluating disease activity and predicting organs/systems damage in SLE for clinical assessments and managements.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Li LH,Pan HF,Li WX,Li XP,Xu JH,Ye DQdoi
10.1007/s10067-009-1240-xsubject
Has Abstractpub_date
2009-11-01 00:00:00pages
1301-7issue
11eissn
0770-3198issn
1434-9949journal_volume
28pub_type
杂志文章abstract：:Because the pathophysiology of knee osteoarthritis is poorly understood, optimal evidence-based clinical management is uncertain. Sibling comparison studies can help inform a clinical model to guide preventive care. We compared the 8-year clinical outcomes in 2 sisters with a family history of osteoarthritis, normal B...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-020-05181-6
更新日期：2020-10-01 00:00:00
abstract：:The aim of the study was to assess mean platelet volume (MPV) in children with systemic lupus erythematosus (SLE) at the active and inactive stages. Twenty children with SLE and 30 age- and gender-matched controls were enrolled. Demographic data, SLE disease activity index (SLEDAI), erythrocyte sedimentation rate (ESR...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-014-2540-3
更新日期：2014-05-01 00:00:00
abstract：:An understanding of the cytokine cascade in a rheumatoid joint has led to the development of new therapeutic options, including drugs targeting tumor necrosis factor-alpha (TNF-alpha). The safety profile of these agents in patients with hepatitis-induced liver disease, however, remains a concern because of risks assoc...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-009-1149-4
更新日期：2009-07-01 00:00:00
abstract：OBJECTIVE:To assess the effectiveness of steroid injection (local treatment, LT) into the digital flexor tendon sheath of dactylitis in psoriatic arthritis (PsA) patients as compared with systemic treatment (ST). METHODS:Forty-six PsA patients with a total of 73 dactylitic fingers were assessed in an observational, mu...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05142-z
更新日期：2020-11-01 00:00:00
abstract：:Anaerobic bacteria are uncommon pathogens in septic arthritis. We report a case of pyarthrosis of the right hip caused by Fusobacterium nucleatum, following a transient synovitis in an otherwise healthy boy. There are only a few cases involving this species described in the literature. This report illustrates the diff...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s100670170072
更新日期：2001-01-01 00:00:00
abstract：:Our aim was to determine reasons for admission, the prevalence and spectrum of infections, and the outcomes in a multiethnic cohort of hospitalized systemic lupus erythematosus (SLE) patients in Durban, South Africa. We reviewed the records of hospitalized SLE patients seen over a 79-month period; the demographic data...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-014-2847-0
更新日期：2015-03-01 00:00:00
abstract：:A cohort of patients with recently diagnosed axial spondyloarthritis (SpA) was characterized with emphasis on gender differences and factors leading to delay in diagnosis. Clinical, laboratory, and imaging data of 151 consecutive patients diagnosed with ankylosing spondylitis or undifferentiated SpA in 2004-2009 and s...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-011-1719-0
更新日期：2011-08-01 00:00:00
abstract：UNLABELLED:There is a paucity of data on the impact of chronic rheumatic diseases on functional disability and overall health-related quality of life (HRQOL) in Africans. MATERIALS AND METHODS:We compared Black South Africans (BSA) with rheumatoid arthritis (RA) (n=50) and systemic lupus erythematosus (SLE) (n=50) to ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-006-0215-4
更新日期：2007-01-01 00:00:00
abstract：BACKGROUND:Visfatin is an adipokine and has a crucial role in pro-inflammatory response. The aim of this study was investigating the visfatin levels of gingival crevicular fluid (GCF) in patients with systemic lupus erythematosus (SLE) and chronic periodontitis and healthy subjects. MATERIALS AND METHODS:Sixty non-obe...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-019-04708-w
更新日期：2019-11-01 00:00:00
abstract：:Brucellosis is a chronic infectious disease with articular involvement. Discrimination between brucellosis and rheumatologic disorders is difficult in regions endemic for brucellosis. There are few studies about the rate of positive autoantibodies as rheumatologic biomarkers in brucellosis, and the prevalence is varia...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-016-3171-7
更新日期：2016-10-01 00:00:00
abstract：:Immunoglobulins are often high in active rheumatoid arthritis and fall when treatment with a slow-acting anti-rheumatic drug is instituted. We assessed the value of monitoring immunoglobulins during penicillamine therapy; 145 patients were followed for up to 5 years, IgA, IgM and IgG levels were compared to 12 other c...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02239191
更新日期：1988-09-01 00:00:00
abstract：OBJECTIVE:This study aimed to identify the clinical characteristics of systemic lupus erythematosus-primary biliary cholangitis (SLE-PBC) patients and to compare the manifestations and prognosis with systemic lupus erythematosus (SLE) patients. METHODS:Twenty-one inpatients with concomitant SLE and primary biliary cho...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05457-x
更新日期：2020-10-16 00:00:00
abstract：OBJECTIVES:Decreased natural killer (NK) cells have been reported in systemic lupus erythematosus (SLE) patients. However, the role of NK cells in the pathogenesis of SLE is not well understood. In this study, we aimed to characterize NK cell subsets, phenotypes, and cytokine-secreting functions and investigate the cli...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05306-x
更新日期：2020-08-14 00:00:00
abstract：:The antichromatin antibody (aCT) has been described as a useful marker for lupus nephropathy. The relevance of its nephritogenic potential may be appropriately evaluated in the context of renal histopathology. Therefore, the present study investigated the relationship of aCT with a particular histopathologic class of ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-008-0939-4
更新日期：2008-11-01 00:00:00
abstract：:Azathioprine (AZA) is indicated for the treatment of systemic lupus erythematosus (SLE). Thiopurine methyltransferase (TPMT) is the rate-limiting enzyme in the steps of AZA metabolization. Heritable deficiency of TPMT enzyme activity and polymorphisms may lead to leukopenia. This study aims to detect TPMT polymorphism...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-013-2441-x
更新日期：2014-04-01 00:00:00
abstract：:Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease causing joint damage and significant functional impairment. Methotrexate (MTX) remains the mainstay for the treatment of RA. MTX inhibits several enzymes of the folate and nucleotide pathways. Thymidylate synthase (TYMS) is an important enzyme in the d...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3608-7
更新日期：2017-06-01 00:00:00
abstract：:The aim of this study is to compare the three classification criteria for rheumatoid arthritis (RA) in a large cohort of early arthritis patients. Patients who had at least one clinically swollen joint with disease duration no more than 1 year and age more than 18 years were enrolled. The clinical and laboratory param...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-016-3281-2
更新日期：2016-10-01 00:00:00
abstract：UNLABELLED:It has been suggested that in some patients non-traumatic aseptic osteonecrosis of the hip (AOH) could be the result of the intra-osseous thrombosis. Antiphospholipid antibodies (APL) have been associated with venous and arterial occlusive events and the association between AOH and APL syndrome has been repo...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02242453
更新日期：1997-06-01 00:00:00
abstract：:Recurrences of COVID-19 were observed in a patient with long-term usage of hydroxychloroquine, leflunomide, and glucocorticoids due to her 30-year history of rheumatoid arthritis (RA). Tocilizumab was applied and intended to target both COVID-19 and RA. However, disease of this patient aggravated after usage of tocili...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-020-05234-w
更新日期：2020-09-01 00:00:00
abstract：:To evaluate the influence of TNF-α inhibitor on lipid profile and atherogenic index of plasma (AIP) in axial spondyloarthritis (axSpA) patients with long-term use of stable dose TNF-α inhibitor. AxSpA patients were enrolled in the Catholic Axial Spondyloarthritis COhort (CASCO). We collected their data annually and an...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-019-04767-z
更新日期：2020-02-01 00:00:00
abstract：:The aim of the study was to determine the prevalence and factors associated with bursitis/tendonitis disorders in Puerto Ricans with diabetes mellitus (DM). A cross-sectional study was performed in 202 adult Puerto Ricans (100 DM patients and 102 non-diabetic subjects). For each participant, a complete medical history...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-013-2474-1
更新日期：2014-07-01 00:00:00
abstract：:Erythema nodosum is an unusual manifestation of Hodgkin's lymphoma. One patient with long remission of Hodgkin's disease manifested persistent erythema nodosum beginning one and three months before relapse was clinically evident. So, the diagnosis of Hodgkin's disease should be considered in patients with unexplained ...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/BF02114402
更新日期：1990-09-01 00:00:00
abstract：:In a patient suffering from rheumatoid arthritis, we report the first simultaneous occurrence of two side effects of low-dose methotrexate: an acute megaloblastic anaemia and a pneumonitis. A combination of methotrexate suspension, folinic acid and corticosteroids led to recovery. The correlation between the haematolo...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02231787
更新日期：1993-12-01 00:00:00
abstract：:IL-34 is a pleiotropic cytokine, which is a key regulator of monocytes/macrophages and might participate in the pathogenesis of RA. In this study, we aimed to explore the effect of IL-34 on the monocyte-like cell line THP-1 and the quantitative variation of Th17 cells in THP-1 and RA CD4+T cells coculture system. CD4+...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3746-y
更新日期：2018-01-01 00:00:00
abstract：:An insufficiency fracture (IF) involving the acetabulum is presented. This fracture occurred in a 67-year-old woman who had been hysterectomized and oophorectomized 27 years earlier for a carcinoma of the uterine cervix, and who had received external pelvic irradiation. This IF location has been rarely described earli...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02207215
更新日期：1992-09-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:The purpose of this study was to develop an understanding of treatment preferences in patients with inflammatory arthritis (IA) [rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA)] focussing on treatment attributes that patients' value, their relative importan...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-019-04843-4
更新日期：2020-04-01 00:00:00
abstract：:The objective of this study is to identify the clinical differences between infectious meningitis and neuropsychiatric systemic lupus erythematosus (NPSLE) in patients with SLE. Clinical manifestations, laboratory test results, and prognoses of 14 SLE patients complicated with various infectious meningitis, hospitaliz...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-014-2726-8
更新日期：2015-02-01 00:00:00
abstract：:Fibromyalgia syndrome (FMS) is characterized by chronic widespread pain and systemic symptoms. The aetiology and pathogenesis of fibromyalgia are not yet fully understood. Blood neutrophil/lymphocyte ratio (NLR) is a marker of systemic inflammatory response. Platelet distribution width (PDW) and mean platelet volume (...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3647-0
更新日期：2017-08-01 00:00:00
abstract：:Primary Sjögren syndrome (pSS)-related interstitial lung disease (ILD) involved about 10-20% of patients. In 20% of cases, ILD can be diagnosed before pSS; anyway, few studies have investigated the frequency of ILD as the first clinically relevant manifestation of pSS, generally referred to retrospective studies. Aim ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3601-1
更新日期：2017-06-01 00:00:00
abstract：:Reactive arthritis (ReA) due to Gram-negative intestinal bacteria or Chlamydia, is associated by an unknown mechanism with HLA-B27. Like other MHC class I molecules, HLA-B27 presents antigenic peptides derived from intracellular proteins to CD8+ cytotoxic T cells (CTL). In humans however, CTL specific for ReA associat...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF03342653
更新日期：1996-01-01 00:00:00
