Prevalence of positive autoimmune biomarkers in the brucellosis patients.

Abstract:

:Brucellosis is a chronic infectious disease with articular involvement. Discrimination between brucellosis and rheumatologic disorders is difficult in regions endemic for brucellosis. There are few studies about the rate of positive autoantibodies as rheumatologic biomarkers in brucellosis, and the prevalence is variable. In this study, the rheumatologic tests were studied in brucellosis patients. This cross sectional study was performed in two teaching hospitals in Tehran, Iran. Forty-nine patients with brucella infection and 42 healthy participants were enrolled in this study. Brucellosis was diagnosed on the basis of the clinical symptoms and positive serology for brucellosis. Rheumatic factor (RF) and antinuclear antibodies (ANA) were evaluated in all patients. Cyclic citrullinated peptides antibody (ACPA) and anti-double strand DNA (anti-dsDNA) were checked in all patients and control groups. Out of 49 patients, 15 (30.6 %) were RF positive and 4 (8.2 %) were ANA positive. Anti-dsDNA was concurrently positive with ANA in 1 patient (2 %) but ACPA titer was positive in 8 patients (16.3 %). None of the patients with positive autoantibody biomarkers fulfilled the criteria for rheumatologic disorders. The rate of positive RF in healthy people was significantly lower than patient group (2.4 vs. 30.6 %), but the positiveness rate of other biomarkers did not have significant difference in two groups. Sixty percent of the patients with positive RF and 75 % with positive ACPA had skeletal involvement (P < 0.05). Autoantibody biomarkers can be positive in brucellosis. Rheumatologists should be aware of brucellosis in patients with musculoskeletal involvement and positive autoantibody biomarkers in endemic regions.

journal_name

Clin Rheumatol

journal_title

Clinical rheumatology

authors

Ahmadinejad Z,Abdollahi A,Ziaee V,Domiraei Z,Najafizadeh SR,Jafari S,Ahmadinejad M

doi

10.1007/s10067-016-3171-7

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

2573-8

issue

10

eissn

0770-3198

issn

1434-9949

pii

10.1007/s10067-016-3171-7

journal_volume

35

pub_type

杂志文章
  • Acute phase proteins and clinical synovitis activity in patients with rheumatoid arthritis.

    abstract::A number of laboratory variables, including Hb., ESR and several phase proteins, fluctuated in concord with the clinical signs of synovitis activity in patients with rheumatoid arthritis during a controlled study of 3 disease-modifying anti-rheumatic drugs (DMARD). The correlation between laboratory variables and clin...

    journal_title:Clinical rheumatology

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF02201028

    authors: Bentzon MW,Gad I,Halberg P,Halskov O,Lorenzen I

    更新日期:1987-06-01 00:00:00

  • Activation status of CD56dim natural killer cells is associated with disease activity of patients with systemic lupus erythematosus.

    abstract:OBJECTIVES:Decreased natural killer (NK) cells have been reported in systemic lupus erythematosus (SLE) patients. However, the role of NK cells in the pathogenesis of SLE is not well understood. In this study, we aimed to characterize NK cell subsets, phenotypes, and cytokine-secreting functions and investigate the cli...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-020-05306-x

    authors: Liu M,Liu J,Zhang X,Xiao Y,Jiang G,Huang X

    更新日期:2020-08-14 00:00:00

  • Bleomycin-induced scleroderma: report of a case with a chronic course rather than the typical acute/subacute self-limiting form.

    abstract::We report a case of bleomycin-induced scleroderma in a 35-year-old woman treated with chemotherapy for Hodgkin's disease. Approximately 6 months after the first chemotherapy cycle, the patient developed skin sclerosis in both arms. The lesion showed no signs of spontaneous clinical amelioration and treatment with ster...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s100670050131

    authors: Passiu G,Cauli A,Atzeni F,Aledda M,Dessole G,Sanna G,Nurchis P,Vacca A,Garau P,Laudadio M,Mathieu A

    更新日期:1999-01-01 00:00:00

  • Rheumatoid arthritis and risk of anxiety: a meta-analysis of cohort studies.

    abstract:OBJECTIVES:Rheumatoid arthritis (RA) may increase the risk of anxiety, but results from prior studies have no consensus. Our study aimed to evaluate the relationship between RA and incident anxiety by using a quantitative meta-analysis. METHODS:A number of databases were used to gather relevant information; they inclu...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,meta分析

    doi:10.1007/s10067-019-04502-8

    authors: Qiu XJ,Zhang XL,Cai LS,Yan C,Yu L,Fan J,Zhang RW,Huang JW,Duan XW

    更新日期:2019-08-01 00:00:00

  • Improving management of musculoskeletal disorders in primary care: the Joint Adventures Program.

    abstract::Musculoskeletal disorders represent a large and growing clinical challenge to primary care clinicians. Unfortunately, there appears to be a gap in current training and continuing education to meet this challenge. We used script concordance within a continuing medical education program entitled "Joint Adventures" to as...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-006-0446-4

    authors: Petrella RJ,Davis P

    更新日期:2007-07-01 00:00:00

  • Subcutaneous nodules are associated with cardiovascular events in patients with rheumatoid arthritis: results from a large US registry.

    abstract::Subcutaneous nodules are the most common conspicuous extra-articular manifestation of rheumatoid arthritis (RA). Cardiovascular disease (CVD) is the leading cause of death in patients with RA. The objective of this study is to examine the possibility of a relationship between subcutaneous nodules and "first ever" card...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-015-3032-9

    authors: Kaushik P,Solomon DH,Greenberg JD,Anderson JT,Reed G,Pala O,Sumbul-Yuksel B,Kadam P,Kremer JM,CORRONA investigators.

    更新日期:2015-10-01 00:00:00

  • Erosive arthritis in a patient with amyloid arthropathy.

    abstract::Amyloid arthropathy is said to be distinguished roentgenographically from rheumatoid arthritis by the absence of joint space narrowing and the absence of articular erosions. We present a patient with multiple myeloma with swelling, stiffness and firm synovial thickening of the wrists, metacarpophalangeal joints and pr...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02032296

    authors: Leonard PA,Clegg DO,Lee RG

    更新日期:1985-06-01 00:00:00

  • Thrombotic events in patients with antiphospholipid syndrome treated with rivaroxaban: a series of eight cases.

    abstract::The current treatment for antiphospholipid syndrome (APS) with thrombotic manifestation is long-term anticoagulation. Vitamin K antagonists (VKA) are usually the agents of choice. However, VKA limitations, such as unpredictable anticoagulation effects due to interaction with diet and other drugs, require regular monit...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-015-3030-y

    authors: Signorelli F,Nogueira F,Domingues V,Mariz HA,Levy RA

    更新日期:2016-03-01 00:00:00

  • Erythema nodosum and Hodgkin's disease.

    abstract::Erythema nodosum is an unusual manifestation of Hodgkin's lymphoma. One patient with long remission of Hodgkin's disease manifested persistent erythema nodosum beginning one and three months before relapse was clinically evident. So, the diagnosis of Hodgkin's disease should be considered in patients with unexplained ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/BF02114402

    authors: Taillan B,Ferrari E,Fuzibet JG,Vinti H,Pesce A,Dujardin P

    更新日期:1990-09-01 00:00:00

  • Infective endocarditis complicating rituximab (anti-CD20 monoclonal antibody) treatment in an SLE patient with a past history of Libman-Sacks endocarditis: a case for antibiotic prophylaxis?

    abstract::We report a 54 year old female whose successful treatment of cerebral lupus with rituximab was complicated by the development of streptococcus intermedius, on valves damaged by Libman-Sacks endocarditis more than 20 years previously. ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-005-0031-2

    authors: Armstrong D,Wright S,McVeigh C,Finch M

    更新日期:2006-07-01 00:00:00

  • Idiopathic retroperitoneal fibrosis: a clinicopathological study in 24 Spanish cases.

    abstract::Idiopathic retroperitoneal fibrosis (IRPF) is a rare condition of unknown aetiology characterized by chronic non-specific inflammation of the retroperitoneum. The aim of this study is to describe, for the first time, the features of Spanish patients with IRPF. In this retrospective study, a clinical description was pe...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-013-2225-3

    authors: Fernández-Codina A,Martínez-Valle F,Castro-Marrero J,Detorres I,Vilardell-Tarrés M,Ordi-Ros J

    更新日期:2013-06-01 00:00:00

  • Efficacy of tripterygium glycosides tablet in treating ankylosing spondylitis: a systematic review and meta-analysis of randomized controlled trials.

    abstract::Hundreds of randomized controlled trials (RCTs) on tripterygium glycosides tablet (TGT) in the treatment of ankylosing spondylitis (AS) have been published, but the therapeutic effects have never been systematically reviewed yet. The aim of this meta-analysis was to evaluate the efficacy of TGT on AS based on RCTs. Pu...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s10067-015-3043-6

    authors: Li H,Guo F,Luo YC,Zhu JP,Wang JL

    更新日期:2015-11-01 00:00:00

  • Factors associated with active tuberculosis in Colombian patients with systemic lupus erythematosus: a case-control study.

    abstract:OBJECTIVE:To identify factors associated with active tuberculosis (TB) in patients with systemic lupus erythematosus (SLE). METHODS:We performed a retrospective case-control study in two tertiary care teaching hospitals in Medellín, Colombia. From January 2007 to December 2017, a total of 268 patients with SLE were in...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-020-05225-x

    authors: González-Naranjo LA,Coral-Enríquez JA,Restrepo-Escobar M,Muñoz-Vahos CH,Jaramillo-Arroyave D,Vanegas-García AL,Eraso R,Vásquez G,Jaimes F

    更新日期:2021-01-01 00:00:00

  • Introduction of a uniform record keeping practice for rheumatology clinics in Sri Lanka-an ILAR project.

    abstract::In Sri Lanka, record keeping in rheumatology clinics is purely paper-based. Clinic record books are given to patients, and the hospital does not retain clinical data. Different clinics and different rheumatology specialists practice different formats of record keeping in Sri Lanka. This project was aimed to develop a ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-018-4320-y

    authors: Deshapriya K

    更新日期:2019-01-01 00:00:00

  • Supraclavicular and axillary lymphadenopathy as the initial manifestation in Wegener's granulomatosis.

    abstract::Wegener's granulomatosis (WG) is a systemic granulomatous vasculitis that typically affects the upper airways, lungs and kidneys. Lymphadenopathy is rare in patients with WG. Here, we present the first case of WG whose initial manifestation was superficial lymphadenopathy (i.e. supraclavicular and axillary lymphadenop...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s100670200128

    authors: Hashizume T,Yamaguchi T,Matsushita K

    更新日期:2002-11-01 00:00:00

  • Reports of three cases with the initial presentation of mesenteric vasculitis in children with system lupus erythematous.

    abstract::We reviewed three cases of systemic lupus erythematosus (SLE) in children with mesenteric vasculitis (LMV) as initial presentation and analysed their clinical characteristics to improve the understanding of this disease. Three patients with SLE were admitted to our hospital and initially presented with gastrointestina...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/s10067-017-3841-0

    authors: Liu Y,Zhu J,Lai JM,Sun XF,Hou J,Zhou ZX,Yuan XY

    更新日期:2018-01-01 00:00:00

  • Outcome of reactive arthritis after an extensive Finnish waterborne gastroenteritis outbreak: a 1-year prospective follow-up study.

    abstract::The purpose of the study was to assess the 1-year outcome of definitive reactive arthritis (ReA) after a waterborne outbreak. A cohort of 21 patients (15 females and 6 males, median age 54 years) with ReA related to an extensive waterborne outbreak in Finland was clinically followed-up by rheumatologists with visits a...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-013-2247-x

    authors: Uotila TM,Antonen JA,Paakkala AS,Mustonen JT,Korpela MM,Pirkanmaa Waterborne Outbreak Study Group.

    更新日期:2013-08-01 00:00:00

  • Sustained cough in methotrexate therapy for rheumatoid arthritis.

    abstract::Sustained cough is a frequent complaint in methotrexate (MTX) treatment for rheumatoid arthritis and can be a symptom of incipient MTX-induced pneumonitis. This study was performed to characterize MTX-associated cough clinically and to clarify by which means this condition can be distinguished from incipient MTX pneum...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02229707

    authors: Schnabel A,Dalhoff K,Bauerfeind S,Barth J,Gross WL

    更新日期:1996-05-01 00:00:00

  • The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain.

    abstract::Low-dose naltrexone (LDN) has been demonstrated to reduce symptom severity in conditions such as fibromyalgia, Crohn's disease, multiple sclerosis, and complex regional pain syndrome. We review the evidence that LDN may operate as a novel anti-inflammatory agent in the central nervous system, via action on microglial ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/s10067-014-2517-2

    authors: Younger J,Parkitny L,McLain D

    更新日期:2014-04-01 00:00:00

  • Interferon-gamma release assays in the detection of latent tuberculosis infection in patients with inflammatory arthritis scheduled for anti-tumour necrosis factor treatment.

    abstract::Biological agents, particularly anti-Tumour Necrosis Factor (TNF)-α agents, have emerged as an effective treatment in patients with chronic inflammatory diseases. An association between anti-TNF-α antibodies and reactivation of latent tuberculosis infection (LTBI) has been established. Appropriate screening for TB inf...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-012-1938-z

    authors: Mínguez S,Latorre I,Mateo L,Lacoma A,Diaz J,Olivé A,Domínguez J

    更新日期:2012-05-01 00:00:00

  • Peripheral neuropathy, polymyalgia and arthralgia: a paraneoplastic syndrome associated with myeloma.

    abstract::We describe a patient with peripheral neuropathy, polymyalgia, arthralgia and cervical vertebral osteosclerosis who was subsequently diagnosed to have fatal multiple myeloma with IgG gammopathy and lambda urinary chains. The initial presentation and clinical features are discussed. ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02031978

    authors: Samanta A,Hilton D,Roy S

    更新日期:1990-06-01 00:00:00

  • The relationship between femoral cartilage thickness and muscle strength in knee osteoarthritis.

    abstract::To explore whether femoral cartilage thickness is related (and changes) with muscle strength in subjects with knee osteoarthritis (OA). Forty patients (27 F, 13 M) with knee OA-who were under quadriceps muscle strengthening program-were enrolled in the study. Isokinetic/isometric knee muscle strength measurements (at ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-016-3271-4

    authors: Tuna S,Balcı N,Özçakar L

    更新日期:2016-08-01 00:00:00

  • Thioredoxin 1 is associated with the proliferation and apoptosis of rheumatoid arthritis fibroblast-like synoviocytes.

    abstract::We aimed to investigate the possible effects of thioredoxin 1 (Trx1) on the proliferation and apoptosis of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs) and elucidate the possible mechanisms involved. We investigated the distribution and expression of Trx1 in synovial tissues from RA and osteoarthritis (...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-017-3832-1

    authors: Lu T,Zong M,Fan S,Lu Y,Yu S,Fan L

    更新日期:2018-01-01 00:00:00

  • Methotrexate-treated arthritis and lymphoproliferative disease--coincidence only?

    abstract::This paper describes four patients with inflammatory joint diseases treated with methotrexate who developed lymphoma either of unusual type or with bizarre clinical features. The pathogenesis of this unusual condition is discussed and the difficulty in differentiating it from the features of the initial disease is emp...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s100670170112

    authors: Braun-Moscovici Y,Schapira D,Balbir-Gurman A,Nahir AM

    更新日期:2001-01-01 00:00:00

  • Hypercalcaemia in systemic lupus erythematosus.

    abstract::Hypercalcaemia is a common electrolyte abnormality. The vast majority of patients will be shown to have either hyperparathyroidism or malignancy. In less than 10% of patients other, less common causes of hypercalcaemia will be present. Systemic lupus erythematosus is a very rare cause of hypercalcaemia. It may be asso...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s100670170088

    authors: Berar-Yanay N,Weiner P,Magadle R

    更新日期:2001-01-01 00:00:00

  • Charcot joint in idiopathic sensorimotor neuropathy.

    abstract::Charcot joint or neuropathic arthropathy is described in certain neurological conditions. We report the case of a man who presented with a swollen ankle 10 days after a long walk, which rapidly progressed to a Charcot joint. A neurological examination revealed areflexia and insensitivity to temperature and pain. Elect...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s100670050036

    authors: Chappel R,Willems J,Martin JJ

    更新日期:2000-01-01 00:00:00

  • Behçet's disease in Lebanon: clinical profile, severity and two-decade comparison.

    abstract::The aim of this study is to describe the clinical features of Lebanese patients with Behçet's disease (BD) followed up at a tertiary care center in Lebanon. A retrospective review of medical records of 90 patients who fulfilled the International Study Group (ISG) criteria for diagnosis was performed. The clinical char...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-005-0058-4

    authors: Hamdan A,Mansour W,Uthman I,Masri AF,Nasr F,Arayssi T

    更新日期:2006-05-01 00:00:00

  • Plasma gelsolin levels in patients with psoriatic arthritis: a possible novel marker.

    abstract:BACKGROUND:Psoriatic arthritis (PsA) is an inflammatory disorder affecting the joints of psoriatic patients. Gelsolin regulated the actin assembly and disassembly. Reduction in plasma gelsolin levels was detected in tissue damages, including trauma, sepsis, and chronic inflammatory disorders. OBJECTIVES:The study aims...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-020-04959-y

    authors: Esawy MM,Makram WK,Albalat W,Shabana MA

    更新日期:2020-06-01 00:00:00

  • Protrusio acetabuli in juvenile rheumatoid arthritis.

    abstract::Acetabular protrusion (PA) as measured by a line crossing method was studied in 73 patients with juvenile rheumatoid arthritis (JRA) and its frequency found to be 12% (9/73), presenting bilaterally in 5 cases and unilaterally in 4. All patients had some other forms of radiological damage and the presence of PA was pre...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02231556

    authors: Gusis SE,Maldonado Cocco JA,Rivero EM,Babini JC,Gagliardi SA

    更新日期:1993-03-01 00:00:00

  • Atherogenic index of plasma: a useful marker for subclinical atherosclerosis in ankylosing spondylitis : AIP associate with cIMT in AS.

    abstract::Ankylosing spondylitis (AS) is associated with an increased risk of atherosclerotic cardiovascular disease (ACD). The atherogenic index of plasma (AIP), which is the logarithmic transformation of the plasma triglyceride (TG) level to the high-density lipoprotein level (HDL) ratio, has been suggested to be a novel mark...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-018-4027-0

    authors: Cure E,Icli A,Uslu AU,Sakiz D,Cure MC,Baykara RA,Yavuz F,Arslan S,Kucuk A

    更新日期:2018-05-01 00:00:00