Abstract：
:Immunoglobulins are often high in active rheumatoid arthritis and fall when treatment with a slow-acting anti-rheumatic drug is instituted. We assessed the value of monitoring immunoglobulins during penicillamine therapy; 145 patients were followed for up to 5 years, IgA, IgM and IgG levels were compared to 12 other clinical and laboratory variables on 903 occasions. Mean levels of IgA and IgG fell by 10-30%. These changes were less than with ESR or clinical measures such as articular index and duration of morning stiffness. Immunoglobulin levels showed weak correlations with other variables. Only a small number of patients had hypogammaglobulinemia. Initially, 5 cases had low IgA with subsequent falls in 3 more. Initially, 2 cases had low IgG with subsequent falls in 5 more. No patients had low IgM levels. These changes seemed clinically irrelevant. Radiological progression was related to IgA levels. Patients with persistently high rates of radiological progression had persistently higher serum IgA. We conclude that IgM gives the most "acute phase" pattern of response. IgA gives more theoretically interesting information, especially concerning radiological progression. There is only a limited amount of clinically valuable information gained from measuring immunoglobulins.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Williams A,Scott DL,Greenwood A,Huskisson ECdoi
10.1007/BF02239191subject
Has Abstractpub_date
1988-09-01 00:00:00pages
347-53issue
3eissn
0770-3198issn
1434-9949journal_volume
7pub_type
杂志文章abstract：:Either total hip arthroplasty (THA), total knee arthroplasty (TKA) or both were performed in 105 patients from 1981 to 1994. These patients were experiencing severe joint destruction in the lower extremities due to rheumatoid arthritis (RA). These patients were followed for more than 2 years after their last operation...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF01452259
更新日期：1998-01-01 00:00:00
abstract：:The objective of this study was to analyze the clinical, laboratorial, and therapeutical response of polymyalgia rheumatica (PMR) to anti-tumor necrosis factor (anti-TNF) treatment. We systematically searched English articles on the subjects of PMR who were treated with TNF blockers in Pubmed from 1994 to 2010. In add...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-011-1914-z
更新日期：2012-03-01 00:00:00
abstract：:Seventy-nine patients suffering from rheumatoid factor positive rheumatoid arthritis (RA) were included in this study. In each patient disease activity was assessed three times at two-week intervals during a four-week period. All factors that might possibly influence RA, except atmospheric conditions (AC) were held co...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02206665
更新日期：1991-12-01 00:00:00
abstract：:Melorheostosis is a very rare bone disease of unknown etiology characterised by linear hyperostosis and associated with fibrosis of soft tissues and the skin. This uncommon sclerosing bone dysplasia was first described by Leri and Joanny in 1922, and since then, until 1993, approximately 300 cases were reported in the...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF01451298
更新日期：1998-01-01 00:00:00
abstract：OBJECTIVE:This study aimed to identify the clinical characteristics of systemic lupus erythematosus-primary biliary cholangitis (SLE-PBC) patients and to compare the manifestations and prognosis with systemic lupus erythematosus (SLE) patients. METHODS:Twenty-one inpatients with concomitant SLE and primary biliary cho...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05457-x
更新日期：2020-10-16 00:00:00
abstract：OBJECTIVE:This case-control study aimed to analyze the clinical features and determine the expression of type I interferon-induced genes in systemic lupus erythematosus (SLE) patients harboring the CD11b rs1143679 single-nucleotide polymorphism (SNP) and elucidate whether it is involved in the relapses of SLE. METHODS...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05330-x
更新日期：2020-08-12 00:00:00
abstract：:To analyze fucosylation of alpha(1)-acid glycoprotein (AGP) and to identify relations between AGP fucosylation and clinical and biochemical indices of disease activity in patients with rheumatoid arthritis (RA) treated with monoclonal antitumor necrosis factor (TNF) antibody infliximab, we examined 22 patients with RA...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-007-0572-7
更新日期：2007-10-01 00:00:00
abstract：:The idiopathic inflammatory myopathies (IIM) constitute a subset of autoimmune conditions primarily affecting muscle, along with many extra-muscular manifestations. Proximal muscle weakness is the dominant symptom in the IIM. In addition, many patients will have cutaneous manifestations, pulmonary manifestations, and ...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-015-2891-4
更新日期：2015-05-01 00:00:00
abstract：:Gold salts in vitro modulate lymphocyte proliferation to mitogens and antigens and macrophage phagocytosis. These effects are not confined to gold salts; D-penicillamine and chloroquine as well as some of the non-steroidal anti-inflammatory drugs (NSAIDs) have in vivo immunoregulatory effects. Peripheral blood mononuc...
journal_title：Clinical rheumatology
pub_type： 临床试验,杂志文章
doi：10.1007/BF03342619
更新日期：1984-03-01 00:00:00
abstract：OBJECTIVE:To investigate the clinical characteristics, laboratory features, and treatment outcomes of Thai patients compared between those with necrotizing autoimmune myopathy (NAM) and those with other idiopathic inflammatory myopathies (IIMs) or non-NAM. METHODS:This multicenter case-control study included patients ...
journal_title：Clinical rheumatology
pub_type： 杂志文章,多中心研究
doi：10.1007/s10067-019-04756-2
更新日期：2019-12-01 00:00:00
abstract：:The ACR/EULAR Boolean remission criteria for rheumatoid arthritis (RA) include a strict cutoff for patient global assessment (PGA, value ≤ 1/10). Near-remission corresponds to remission for joint counts and C-reactive protein but with PGA > 1. The objective was to explore whether the contribution of PGA to remission a...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-018-3998-1
更新日期：2018-06-01 00:00:00
abstract：:This cross-sectional investigation examined the prevalence and severity of dysphonia, globus pharyngeus, and dysphagia in patients affected by immunomediated (IM) diseases. Seventy subjects were administered the Voice Handicap Index (VHI) (scale 0-4), Glasgow-Edinburgh Throat Scale (GETS) (scale from 0 to 7) for globu...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-018-4129-8
更新日期：2019-01-01 00:00:00
abstract：INTRODUCTION/OBJECTIVES:Cardiovascular risk management of patients with systemic lupus erythematosus (SLE) is medically relevant. The objectives were to estimate the cardiovascular risk by different strategies in patients with SLE, analyzing which proportion of patients would be candidates to receive statin therapy, an...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-019-04856-z
更新日期：2020-02-01 00:00:00
abstract：:Recently, the Ankylosing Spondylitis Disease Activity Score (ASDAS), a new index, has been shown to be validated and highly discriminatory in assessing ankylosing spondylitis (AS) disease activity. This study is to evaluate the performance of ASDAS in a local Chinese cohort of AS in a cross-sectional setting and to co...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-014-2729-5
更新日期：2014-08-01 00:00:00
abstract：OBJECTIVES:This study was conducted to assess the safety and efficacy of intra-articular injection of etanercept and compare it with corticosteroid injection in rheumatoid arthritis (RA) patients. METHODS:Fifty patients with RA who suffered from activity in one joint were randomized into two groups, received an intra-...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05235-9
更新日期：2021-02-01 00:00:00
abstract：:Acute phase proteins, synovial fluid (SF) cellular infiltrates, pro-inflammatory (TNF-alpha, IL-1alpha, IL-6) and Th1 (IL-2) and Th2 (IL-4) derived cytokine levels both in plasma and SF were examined in pauciarticular and polyarticular juvenile chronic arthritis (JCA) patients during the active (n = 22) and inactive (...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF01451007
更新日期：1998-01-01 00:00:00
abstract：:Adropin, a secreted protein, is encoded by the energy homeostasis associated (ENHO) gene. It has been implicated in the several physiological and pathological processes such as angiogenesis and apoptosis. Therefore, the aim of present study was to investigate serum adropin levels and ENHO gene expressions in systemic ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-016-3266-1
更新日期：2016-06-01 00:00:00
abstract：:A case of left brachial plexus compression by an iatrogenic arteriovenous fistula was treated by detachable balloon technique with immediate relief of pain. Good results on paresia were obtained in a few weeks. ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02330599
更新日期：1987-12-01 00:00:00
abstract：:A possible role of tumor necrosis factor alpha (TNFalpha) in the pathomechanism of sarcoidosis must be considered in the analysis of this disorder since elevated concentrations of this cytokine have been found. In addition, TNFalpha expression could be demonstrated in sarcoid granulomata [1]. It is well known that TNF...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-005-0037-9
更新日期：2006-07-01 00:00:00
abstract：:The above article originally published with an error present in Table 2 and is now presented correctly in this article. ...
journal_title：Clinical rheumatology
pub_type： 杂志文章,已发布勘误
doi：10.1007/s10067-018-4280-2
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND:The early detection of psoriatic arthritis (PSA) poses a challenge to rheumatologists, even when their diagnosis is aided by sonography. In order to facilitate early detection of PSA among patients with psoriasis (PSO), we retrospectively analyzed of the relationships between serological markers and comorbid...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05132-1
更新日期：2020-12-01 00:00:00
abstract：:Chronic hepatitis C virus (HCV) viremia has been known to provoke a plethora of autoimmune syndromes referred to as extrahepatic manifestations of chronic HCV infection. Aim of the current study was to assess the prevalence of rheumatologic manifestations among Egyptians with hepatitis C infection and its' association...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-010-1463-x
更新日期：2010-12-01 00:00:00
abstract：:Wegener's granulomatosis (WG) is a systemic granulomatous vasculitis that typically affects the upper airways, lungs and kidneys. Lymphadenopathy is rare in patients with WG. Here, we present the first case of WG whose initial manifestation was superficial lymphadenopathy (i.e. supraclavicular and axillary lymphadenop...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s100670200128
更新日期：2002-11-01 00:00:00
abstract：:Adult-onset Still's disease (AOSD) has often been regarded as the adult spectrum of systemic juvenile idiopathic arthritis (sJIA). The present study aims to compare the clinical and laboratory features, the disease course and the response to treatment in patients having AOSD with those having sJIA. Retrospective revie...
journal_title：Clinical rheumatology
pub_type： 杂志文章,多中心研究
doi：10.1007/s10067-005-0138-5
更新日期：2006-09-01 00:00:00
abstract：INTRODUCTION/OBJECTIVES:To determine the prevalence and factors associated with medication noncompliance by Thai patients with rheumatoid arthritis (RA). METHODS:This prospective cohort study enrolled 443 adult RA patients (≥ 18 years) who were followed up at the outpatient rheumatology clinics of Siriraj Hospital and...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05409-5
更新日期：2020-09-21 00:00:00
abstract：OBJECTIVES:The aim of this study is to analyze the prevalence of myositis-specific autoantibodies (MSAs) and to elucidate their associations with clinical features in Chinese patients with polymyositis (PM) and dermatomyositis (DM). METHODS:Twelve subsets of MSAs including anti-Mi-2, anti-TIF1-γ, anti-MDA5, anti-NXP2,...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-019-04503-7
更新日期：2019-08-01 00:00:00
abstract：:This study aimed to investigate the multiple values of 18F-FDG PET/CT in detecting malignant tumors, evaluating myopathy, and determining interstitial lung disease in patients with idiopathic inflammatory myopathy (IIM). We retrospectively analyzed the data of 38 patients who were examined by 18F-FDG PET/CT and eventu...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3794-3
更新日期：2017-10-01 00:00:00
abstract：:The autoantibody profiles in New Zealand systemic sclerosis patients have not previously been reported. The aim of this study was to evaluate the autoantibody profiles of patients in the Waikato Hospital Systemic Sclerosis Clinic cohort. The EUROLINE (IgG) Systemic Sclerosis panel test kit (which tests for Scl-70, CEN...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-015-2981-3
更新日期：2015-11-01 00:00:00
abstract：OBJECTIVE:To identify factors associated with active tuberculosis (TB) in patients with systemic lupus erythematosus (SLE). METHODS:We performed a retrospective case-control study in two tertiary care teaching hospitals in Medellín, Colombia. From January 2007 to December 2017, a total of 268 patients with SLE were in...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05225-x
更新日期：2021-01-01 00:00:00
abstract：:The aim of this study was to investigate the association of two common interleukin 12B (IL-12B) polymorphisms (rs3212227 and rs6887695) with rheumatoid arthritis (RA) susceptibility through meta-analyses. A systematic literature search of PubMed, Web of Science, Cochrane Library, and Embase databases was conducted on ...
journal_title：Clinical rheumatology
pub_type： 杂志文章,meta分析
doi：10.1007/s10067-016-3327-5
更新日期：2017-02-01 00:00:00
