Abstract:
:The aim of this study was to investigate the association of two common interleukin 12B (IL-12B) polymorphisms (rs3212227 and rs6887695) with rheumatoid arthritis (RA) susceptibility through meta-analyses. A systematic literature search of PubMed, Web of Science, Cochrane Library, and Embase databases was conducted on articles published before 28 February 2016. Then odds ratio (OR) with 95 % confidence interval (CI) was used to quantify the strength of association for homozygote, heterozygote, dominant, and recessive genetic models. Nine articles with a total of 17 case-control studies (12 for IL-12B rs3212227 polymorphism and 5 for IL-12B rs6887695 polymorphism) met our inclusion criteria. The pooled results demonstrated that IL-12B rs3212227 (homozygote model: OR = 0.96, 95 % CI = 0.81-1.15; heterozygote model: OR = 1.07, 95 % CI = 0.93-1.23; dominant model: OR = 1.05, 95 % CI = 0.91-1.20; recessive model: OR = 0.93, 95 % CI = 0.79-1.10) and rs6887695 (homozygote model: OR = 1.01, 95 % CI = 0.84-1.21; heterozygote model: OR = 1.14, 95 % CI = 0.86-1.51; dominant model: OR = 1.14, 95 % CI = 0.87-1.48; recessive model: OR = 1.01, 95 % CI = 0.85-1.21) polymorphisms may not be associated with RA risk. Our meta-analyses demonstrated that IL-12B rs3212227 and rs6887695 polymorphisms do not confer susceptibility to RA.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Yang X,Xiao F,Luo D,Wang G,Liang Sdoi
10.1007/s10067-016-3327-5subject
Has Abstractpub_date
2017-02-01 00:00:00pages
299-307issue
2eissn
0770-3198issn
1434-9949pii
10.1007/s10067-016-3327-5journal_volume
36pub_type
杂志文章,meta分析abstract::In this study, we aimed to evaluate the relation between angiogenesis indicators and T helper 17 cytokine group in patients with systemic sclerosis (SSc) which is a disease characterized by impaired angiogenesis and autoimmune response. In our study, patients with SSc are compared with patients with primary Raynaud's ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
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更新日期:2013-11-01 00:00:00
abstract::HLA B27 and other clinical findings were investigated in 18 Turkish patients with Reiter's syndrome (mean age 35.8 +/- 8.09). Male/female ratio was 2/1. All 18 patients were seronegative, 12 (66.6%) presenting with an asymmetrical oligoarticular arthritis. Radiological sacroiliitis and enthesopathy was found in 9 (50%...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02207965
更新日期:1992-06-01 00:00:00
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journal_title:Clinical rheumatology
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02208347
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journal_title:Clinical rheumatology
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更新日期:2012-05-01 00:00:00
abstract::HLA-II molecules are critical in triggering human immune response, especially in activating CD4+ T cells. HLA-DP, belonging to HLA-II molecules, draws increasing attention for its role in presentation of viral antigen and autoantigen to T cells. Researches reported single nucleotide polymorphism (SNP) of HLA-DP associ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4030-5
更新日期:2018-07-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02208080
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abstract:OBJECTIVES:To assess the efficacy and safety of the commonly used urate-lowering therapies (ULTs): febuxostat, allopurinol, and lesinurad in hyperuricemic patients with gout. METHODS:We included all randomized controlled trials (RCTs) that compared ULTs with placebo or head to head. The primary efficacy endpoint was t...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05272-4
更新日期:2021-02-01 00:00:00
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journal_title:Clinical rheumatology
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pub_type: 杂志文章
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-016-3347-1
更新日期:2016-11-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-008-0850-z
更新日期:2008-06-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02214106
更新日期:1989-03-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02208090
更新日期:1995-01-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02201022
更新日期:1987-06-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-006-0435-7
更新日期:2007-06-01 00:00:00
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journal_title:Clinical rheumatology
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doi:10.1007/s10067-009-1242-8
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doi:10.1007/BF02249013
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doi:10.1007/s10067-009-1149-4
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journal_title:Clinical rheumatology
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doi:10.1007/BF02031268
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journal_title:Clinical rheumatology
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pub_type: 杂志文章,评审
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journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
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更新日期:2012-09-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:
更新日期:1994-12-01 00:00:00
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journal_title:Clinical rheumatology
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doi:10.1007/s10067-006-0412-1
更新日期:2007-07-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02030965
更新日期:1986-01-01 00:00:00