Bisphosphonate treatment in craniofacial fibrous dysplasia--a case report and review of the literature.

Abstract:

:Fibrous dysplasia (FD) is a benign skeletal disorder which may affect one or multiple bones. Lesions often involve long bones, ribs, and craniofacial bones and cause pain, fractures, and disfigurement. We describe an adolescent girl with mandibular FD who was successfully treated with bisphosphonates. She presented with a tumor-like lesion of the mandible. During the 2-year follow-up, the lesion expanded and caused significant disfigurement and pain necessitating psychiatric support. Treatment with bisphosphonate administered intravenously resulted in rapid pain relief, normalization of bone turnover, and cosmetic improvement. Management of FD has previously consisted of either conservative follow-up or surgery depending on disease activity and localization. Based on published reports and our experience, bisphosphonates should be considered in the treatment of symptomatic cases. This line of treatment may be suitable especially for craniofacial FD in which surgical treatment is particularly challenging.

journal_name

Clin Rheumatol

journal_title

Clinical rheumatology

authors

Mäkitie AA,Törnwall J,Mäkitie O

doi

10.1007/s10067-008-0842-z

subject

Has Abstract

pub_date

2008-06-01 00:00:00

pages

809-12

issue

6

eissn

0770-3198

issn

1434-9949

journal_volume

27

pub_type

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