Abstract:
:Fibrous dysplasia (FD) is a benign skeletal disorder which may affect one or multiple bones. Lesions often involve long bones, ribs, and craniofacial bones and cause pain, fractures, and disfigurement. We describe an adolescent girl with mandibular FD who was successfully treated with bisphosphonates. She presented with a tumor-like lesion of the mandible. During the 2-year follow-up, the lesion expanded and caused significant disfigurement and pain necessitating psychiatric support. Treatment with bisphosphonate administered intravenously resulted in rapid pain relief, normalization of bone turnover, and cosmetic improvement. Management of FD has previously consisted of either conservative follow-up or surgery depending on disease activity and localization. Based on published reports and our experience, bisphosphonates should be considered in the treatment of symptomatic cases. This line of treatment may be suitable especially for craniofacial FD in which surgical treatment is particularly challenging.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Mäkitie AA,Törnwall J,Mäkitie Odoi
10.1007/s10067-008-0842-zsubject
Has Abstractpub_date
2008-06-01 00:00:00pages
809-12issue
6eissn
0770-3198issn
1434-9949journal_volume
27pub_type
杂志文章,评审abstract::Knee osteoarthritis is a common joint problem leading to an increase of pain and a loss of function in older individuals. The main objective of this study was to evaluate if a participant who was randomly assigned to his preferred group improved his adherence to an effective walking program compared to a participant w...
journal_title:Clinical rheumatology
pub_type: 杂志文章,随机对照试验
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更新日期:2017-07-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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journal_title:Clinical rheumatology
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更新日期:1983-06-01 00:00:00
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journal_title:Clinical rheumatology
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更新日期:2021-02-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1993-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-07-01 00:00:00
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更新日期:2016-12-01 00:00:00
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更新日期:1996-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s100670170112
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pub_type: 杂志文章
doi:10.1007/s10067-008-0910-4
更新日期:2008-10-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2011-03-01 00:00:00