Abstract:
:We describe the case of a 26-year-old African female who was treated successfully with belimumab in a case of severe membranous lupus nephritis and retinal vasculitis, resistant to first line therapy. She presented initially with chronic dacryoadenitis and screening showed nephrotic-range proteinuria. Biopsy of the kidney confirmed the diagnosis of membranous lupus nephritis. Clinical features (joint pain, dacryoadenitis, retinal vasculitis and lupus nephritis) in combination with serology (positive anti-double-stranded DNA (ds-DNA) antibodies, hypocomplementemia) confirmed the diagnosis of systemic lupus erythematosus (SLE). Treatment was immediately initiated with glucocorticosteroids (GCS), mycophenolate mofetil (MMF) and hydroxychloroquine sulphate (Plaquenil®). Tacrolimus was associated but no effect was observed with the proteinuria remaining in the nephrotic range and secondary effects of the glucocorticosteroids becoming a real concern. The patient was started on add-on belimumab with quasi-immediate effect on the proteinuria, making it possible to decrease the dosage of the other immunosuppressants and gradually stop them, even the GCS. The patient is currently in complete remission after 3 years of treatment with belimumab. We were able to stop immunosuppressive treatment but will keep her on antimalarial treatment as the most recent guidelines in treatment of SLE recommend.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
De Scheerder MA,Boey O,Mahieu E,Vanuytsel J,Bogaert AMdoi
10.1007/s10067-015-3153-1subject
Has Abstractpub_date
2016-06-01 00:00:00pages
1649-53issue
6eissn
0770-3198issn
1434-9949pii
10.1007/s10067-015-3153-1journal_volume
35pub_type
杂志文章abstract::Psoriatic arthritis (PsA) is an inflammatory arthropathy, associated with skin and/or nail psoriasis and other possible systemic features. In the last years, PsA therapy has been revolutionized by the increasing knowledge in the pathogenetic mechanisms of the disease, involving dysfunction and oversecretion of multipl...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-014-2603-5
更新日期:2014-09-01 00:00:00
abstract::In this study, we aimed to evaluate the relation between angiogenesis indicators and T helper 17 cytokine group in patients with systemic sclerosis (SSc) which is a disease characterized by impaired angiogenesis and autoimmune response. In our study, patients with SSc are compared with patients with primary Raynaud's ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-013-2317-0
更新日期:2013-11-01 00:00:00
abstract::Our aim was to determine reasons for admission, the prevalence and spectrum of infections, and the outcomes in a multiethnic cohort of hospitalized systemic lupus erythematosus (SLE) patients in Durban, South Africa. We reviewed the records of hospitalized SLE patients seen over a 79-month period; the demographic data...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-014-2847-0
更新日期:2015-03-01 00:00:00
abstract::The original version of this article was revised due to a retrospective Open Access order. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,已发布勘误
doi:10.1007/s10067-020-05278-y
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVES:In people with rheumatoid arthritis (RA), mental health problems are common, but often not recognized or treated, contributing to increased morbidity and mortality. Most studies examining the impact of mental health problems in RA have focused on depression. We aimed to determine the association between anxi...
journal_title:Clinical rheumatology
pub_type: 杂志文章,meta分析
doi:10.1007/s10067-019-04900-y
更新日期:2020-05-01 00:00:00
abstract::Pain is a leading cause of morbidity worldwide, with published data showing its prevalence as high as 50% for chronic pain in the European population. This prevalence is likely to continue to rise, particularly in elderly people with comorbid conditions and complex aetiologies of pain. There is thus a rapidly growing ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-006-0311-5
更新日期:2006-01-01 00:00:00
abstract::This study quantified the association between recreational physical activity and daily function in women with fibromyalgia, and determined if this association is mediated by symptoms of pain, depression, or body mass. Twenty-three women diagnosed with fibromyalgia participated in an observational survey study. Recreat...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-013-2386-0
更新日期:2015-01-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-014-2776-y
更新日期:2016-01-01 00:00:00
abstract::Mycoleptodiscus indicus is a recognized plant pathogen which has very rarely been reported as a cause of human infection. It is a tropical or subtropical fungus which is difficult to culture and identify from clinical specimens. This is the first report of septic arthritis with this fungus in a healthy Canadian male. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-010-1448-9
更新日期:2010-09-01 00:00:00
abstract::Despite the proven health benefits, patients with rheumatoid arthritis (RA) are found to be less physically active than their healthy peers. The aim of this study was to examine to what extent and how physical activity, defined as any bodily movement resulting in energy expenditure, is currently promoted by health car...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-011-1846-7
更新日期:2011-12-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 临床试验,杂志文章
doi:10.1007/BF01450959
更新日期:1998-01-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-004-0906-7
更新日期:2004-08-01 00:00:00
abstract::Paediatric systemic lupus erythematosus (pSLE) refers to childhood-onset systemic lupus erythematosus. pSLE has its own unique characteristics, and its pathogenesis is unclear. To study the relationship between microRNAs (miRNAs) and pSLE, we selected three pSLE patients who were newly diagnosed and had not yet been t...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-014-2583-5
更新日期:2014-06-01 00:00:00
abstract::To analyse efficacy and safety of tocilizumab in patients with rheumatoid arthritis (RA) and an inadequate response to conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) and/or tumour necrosis factor (TNF) inhibitors of the Swiss and Austrian patients from the ACT-SURE study. This is a sub-analys...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3779-2
更新日期:2017-10-01 00:00:00
abstract::Over the last few years, several studies in patients with systemic lupus erythematosus (SLE) have demonstrated an association between valvulopathy, including Libman-Sacks endocarditis (LS) and the presence of antiphospholipid antibodies (aPL), suggesting a role of these antibodies in the pathogenesis of the lesions. O...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-010-1662-5
更新日期:2011-02-01 00:00:00
abstract::We report a case of a 53-year-old woman diagnosed of systemic sclerosis. She underwent an episode of pulmonary haemorrhage, characterized by haemoptysis, sudden anaemization, and bilateral alveolar infiltration during her hospitalization, which was resolved with steroid treatment. Subsequently, she developed a focal n...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/BF02207098
更新日期:1992-03-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02032105
更新日期:1989-12-01 00:00:00
abstract::Antibodies to beta(2)-glycoprotein I (anti-beta(2)-GPI) have been reported to have stronger association with clinical antiphospholipid syndrome (APS) than anticardiolipin antibodies (aCL) and lupus anticoagulant (LAC). We investigated the sensitivity and specificity of ELISA for anti-beta(2)-GPI in Thai systemic lupus...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-007-0566-5
更新日期:2007-10-01 00:00:00
abstract::Hydroxyapatite (HA) crystal deposition disease is a common cause of acute inflammatory articular or periarticular pain. Here we report a patient with an acute hip arthritis due to HA crystal deposition of the round ligament. Therefore, HA crystal deposition in periarticular tendons and ligaments of the hip should be a...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-009-1089-z
更新日期:2009-04-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-019-04754-4
更新日期:2020-01-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02207201
更新日期:1992-09-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-020-05234-w
更新日期:2020-09-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05142-z
更新日期:2020-11-01 00:00:00
abstract::The presentation of the Table 1 of the original version of this article was incorrectly published. The Table is now presented correctly in this article. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,已发布勘误
doi:10.1007/s10067-018-4098-y
更新日期:2018-09-01 00:00:00
abstract::Rheumatoid arthritis (RA) is a progressive inflammatory disease. Although the etiology and pathogenesis of RA are not known well, genetic and environmental factors are proposed to initiate an autoimmune process. We aimed to investigate mRNA expression levels of Toll-like receptor-2 (TLR-2), TLR-4, and interleukin-6 (I...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-016-3282-1
更新日期:2016-11-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-014-2679-y
更新日期:2014-01-01 00:00:00
abstract::Mycophenolate mofetil (MMf) has recently been reported as a useful alternative immunosuppressive drug in autoimmune diseases. There is paucity of literature on its use in Takayasu's arteritis (TA). The aim of this study was to assess the safety and efficacy of MMf in Asian Indian patients with Takayasu's arteritis. Re...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-009-1333-6
更新日期:2010-03-01 00:00:00
abstract::This study aims to examine the needs and preferences regarding the delivery of health care services and information provision and their determinants in patients with systemic sclerosis (SSc). A questionnaire was sent to 77 SSc outpatients, comprising 27 items on health care needs within the domains physical, psycholog...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-010-1645-6
更新日期:2011-06-01 00:00:00
abstract::We investigated the association between smoking and the disease activity, functional ability, physical mobility, and systemic inflammation in Chinese ankylosing spondylitis (AS) patients. Seventy five male Chinese AS patients in Taiwan were enrolled in the cross-sectional study. These patients fulfilled the 1984 modif...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-013-2165-y
更新日期:2013-05-01 00:00:00
abstract::While fibromyalgia is frequently associated with ear-related symptoms such as feeling of ear fullness, earache, and tinnitus, the pathogenesis of these ear-related symptoms in fibromyalgia patients is unknown. Here, we focused on clarifying the pathogenesis of ear fullness, a particularly common symptom observed in fi...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-013-2287-2
更新日期:2013-10-01 00:00:00